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Microorganisms, Volume 11, Issue 4 (April 2023) – 277 articles
The temporal origin reconstruction placed the common ancestor around October 10, 2022. Phylogeny indicates the lack of geographic structure and demographic analyses suggest the reaching of the plateau phase on 24 November 2022, with a relatively low evolutionary rate (6.9 × 10-4 subs/sites/years).
The comparison of the portion of the RBD-ACE2 interface indicates that XBB.1.5 differs from its ancestor XBB.1 for the mutations at position 486, where the serine is replaced by the proline.
The SARS-CoV-2 XBB.1.5 variant does not currently show evidence for a particularly high risk to become a new, global public health threat. View this paper
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