Microorganisms, Volume 10, Issue 10
2022 October - 216 articles
Cover Story: Biofilm formation by Salmonella typhimurium and Escherichia coli is a common ancient multicellular behavior relevant in cell–cell and inter-organism interactions equally, as in interaction with biotic and abiotic surfaces. Two characteristic extracellular matrix components amyloid curli fimbriae and the exopolysaccharide cellulose promote biofilm formation. The expression of these biofilm-promoting factors is regulated by the orphan transcriptional regulator CsgD. We found that GreA/GreB, proteins that interact with RNA polymerase to selectively overcome transcriptional pausing, are required for the expression of the csgD operon and consequently for biofilm formation. In the model proposed, the Gre factors suppress transcriptional pausing at the 5′-UTR of the csgD gene. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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