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Volume 6
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10.3390/pathogens6020016
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Article

Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response

by
Cynthia Calzas
1,
Morgan Taillardet
2,
Insaf Salem Fourati
3,
David Roy
1,
Marcelo Gottschalk
1,
Hugo Soudeyns
3,
Thierry Defrance
2 and
Mariela Segura
1,*
1
Swine and Poultry Infectious Diseases Research Center (CRIPA), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, 3200 Sicotte St., Saint-Hyacinthe, QC J2S 2M2, Canada
2
CIRI, INSERM, U1111, CNRS UMR5308, University of Lyon 1, 21 Avenue Tony Garnier, 69007 Lyon, France
3
Department of Microbiology, Infectiology and Immunology, Faculty of Medicine, University of Montreal, C.P. 6128, Succ. Centre-ville, Montreal, QC H3C 3J7, Canada
*
Author to whom correspondence should be addressed.
Pathogens 2017, 6(2), 16; https://doi.org/10.3390/pathogens6020016
Submission received: 27 February 2017 / Revised: 15 April 2017 / Accepted: 17 April 2017 / Published: 20 April 2017
(This article belongs to the Special Issue Streptococcus suis)
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Abstract

Streptococcus suis and group B Streptococcus (GBS) are encapsulated streptococci causing septicemia and meningitis. Antibodies (Abs) against capsular polysaccharides (CPSs) have a crucial protective role, but the structure/composition of the CPS, including the presence of sialic acid, may interfere with the generation of anti-CPS Ab responses. We investigated the features of the CPS-specific Ab response directed against S. suis serotypes 2 and 14 and GBS serotypes III and V after infection or immunization with purified native or desialylated CPSs in mice. Whereas S. suis-infected mice developed a very low/undetectable CPS-specific IgM response, significant anti-CPS IgM titers were measured in GBS-infected animals (especially for type III GBS). No isotype switching was detected in S. suis- or GBS-infected mice. While the expression of sialic acid was essential for the immunogenicity of purified GBS type III CPS, this sugar was not responsible for the inability of purified S. suis types 2, 14 and GBS type V CPSs to induce a specific Ab response. Thus, other biochemical criteria unrelated to the presence of sialic acid may be responsible for the inaptitude of the host immune system to mount an effective response against certain S. suis and GBS CPS types.
Keywords: Streptococcus suis; group B Streptococcus; capsular polysaccharide; sialic acid; humoral response; murine B cells Streptococcus suis; group B Streptococcus; capsular polysaccharide; sialic acid; humoral response; murine B cells

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MDPI and ACS Style

Calzas, C.; Taillardet, M.; Fourati, I.S.; Roy, D.; Gottschalk, M.; Soudeyns, H.; Defrance, T.; Segura, M. Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response. Pathogens 2017, 6, 16. https://doi.org/10.3390/pathogens6020016

AMA Style

Calzas C, Taillardet M, Fourati IS, Roy D, Gottschalk M, Soudeyns H, Defrance T, Segura M. Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response. Pathogens. 2017; 6(2):16. https://doi.org/10.3390/pathogens6020016

Chicago/Turabian Style

Calzas, Cynthia, Morgan Taillardet, Insaf Salem Fourati, David Roy, Marcelo Gottschalk, Hugo Soudeyns, Thierry Defrance, and Mariela Segura. 2017. "Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response" Pathogens 6, no. 2: 16. https://doi.org/10.3390/pathogens6020016

APA Style

Calzas, C., Taillardet, M., Fourati, I. S., Roy, D., Gottschalk, M., Soudeyns, H., Defrance, T., & Segura, M. (2017). Evaluation of the Immunomodulatory Properties of Streptococcus suis and Group B Streptococcus Capsular Polysaccharides on the Humoral Response. Pathogens, 6(2), 16. https://doi.org/10.3390/pathogens6020016

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