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Pathogens, Volume 13, Issue 4

April 2024 - 77 articles

Cover Story: HTLV-1 establishes a persistent lifelong infection by evading the host immune response, in part through the functions of the viral p12 protein. Viruses that do not express p12 (HTLV-1p12KO) cannot persistently infect macaques, and the transient depletion of monocytes prior to virus exposure allows early seroconversion, which is not sustained over time. To test whether HTLV-1 persistence depends on a monocyte reservoir or if monocyte depletion provides a transient immune evasion benefit, we simultaneously depleted NK, CD8+ T cells, and monocytes (triple depletion) prior to exposure to HTLV-1p12KO. Triple depletion resulted in the exacerbation of infection and the complete rescue of HTLV-1p12KO infectivity. This underscores the role of monocytes in orchestrating anti-viral immunity and the importance of p12 in hijacking host immunity. View this paper
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Articles (77)

  • Case Report
  • Open Access
2 Citations
2,709 Views
9 Pages

Mycobacteriosis in a Pet Ferret (Mustela putorius furo) Caused by Mycobacterium xenopi: A Case Report on Neglected Risk of Zoonotic Transmission

  • Željko Mihaljević,
  • Irena Reil,
  • Josipa Habuš,
  • Zrinka Štritof,
  • Šimun Naletilić,
  • Gabrijela Jurkić Krsteska,
  • Tajna Kovač,
  • Maja Zdelar-Tuk,
  • Sanja Duvnjak and
  • Silvio Špičić

Ferrets are highly susceptible to a wide range of mycobacteria, mainly M. bovis, M. avium, and M. triplex. Therefore, ferrets pose a risk of transmission of mycobacteriosis, especially zoonotically relevant tuberculosis. The aim of this study was to...

  • Article
  • Open Access
1,825 Views
13 Pages

Staphylococcus epidermidis is a major contributor to bacterial infections on medical implants, currently treated by surgical removal of the device and the surrounding infected tissue at considerable morbidity and expense. In situ hyperthermia is bein...

  • Article
  • Open Access
3 Citations
1,958 Views
19 Pages

Cold Plasma Deposition of Tobramycin as an Approach to Localized Antibiotic Delivery to Combat Biofilm Formation

  • Beatrice Olayiwola,
  • Fiona O’Neill,
  • Chloe Frewen,
  • Darren F. Kavanagh,
  • Rosemary O’Hara and
  • Liam O’Neill

Hospital-acquired infections (HAIs) remain a significant factor in hospitals, with implant surfaces often becoming contaminated by highly resistant strains of bacteria. Recent studies have shown that electrical plasma discharges can reduce bacterial...

  • Review
  • Open Access
5 Citations
2,404 Views
13 Pages

Are Kidneys Affected by SARS-CoV-2 Infection? An Updated Review on COVID-19-Associated AKI

  • Fabrizio Fabrizi,
  • Luca Nardelli,
  • Anna Regalia,
  • Francesca Zanoni and
  • Giuseppe Castellano

Background: Human kidneys are an important target of SARS-CoV-2 infection, and many renal abnormalities have been found in patients with SARS-CoV-2 infection, including proteinuria, hematuria, and acute kidney injury. Acute kidney injury is now consi...

  • Article
  • Open Access
2 Citations
2,451 Views
22 Pages

Scientometrics Evaluation of Published Scientific Papers on the Use of Proteomics Technologies in Mastitis Research in Ruminants

  • Maria V. Bourganou,
  • Dimitris C. Chatzopoulos,
  • Daphne T. Lianou,
  • George Th. Tsangaris,
  • George C. Fthenakis and
  • Angeliki I. Katsafadou

The objective of this study was the presentation of quantitative characteristics regarding the scientific content and bibliometric details of the relevant publications. In total, 156 papers were considered. Most papers presented original studies (n =...

  • Review
  • Open Access
15 Citations
5,793 Views
12 Pages

The Last Mile in Polio Eradication: Program Challenges and Perseverance

  • Rocio Lopez Cavestany,
  • Martin Eisenhawer,
  • Ousmane M. Diop,
  • Harish Verma,
  • Arshad Quddus and
  • Ondrej Mach

As the Global Polio Eradication Initiative (GPEI) strategizes towards the final steps of eradication, routine immunization schedules evolve, and high-quality vaccination campaigns and surveillance systems remain essential. New tools are consistently...

  • Article
  • Open Access
1 Citations
2,286 Views
13 Pages

Effect of Live and Fragmented Saccharomyces cerevisiae in the Feed of Pigs Challenged with Mycoplasma hyopneumoniae

  • Gabriela Vega-Munguía,
  • Alejandro Vargas Sánchez,
  • Juan E. Camacho-Medina,
  • Luis Suárez-Vélez,
  • Gabriela Bárcenas-Morales,
  • David Quintar Guerrero,
  • Abel Ciprian-Carrasco and
  • Susana Mendoza Elvira

Currently, the responsible use of antimicrobials in pigs has allowed the continuous development of alternatives to these antimicrobials. In this study, we describe the impact of treatments with two probiotics, one based on live Saccharomyces cerevisi...

  • Article
  • Open Access
1 Citations
2,784 Views
12 Pages

Hepatitis C Prevalence and Birth Outcomes among Pregnant Women in the United States: A 2010–2020 Population Study

  • Paul Wasuwanich,
  • Songyos Rajborirug,
  • Robert S. Egerman,
  • Tony S. Wen and
  • Wikrom Karnsakul

Background: The rates of hepatitis C virus (HCV) infection have increased in the pregnant population. We aim to describe the age-stratified clinical outcomes and trends for inpatient pregnant women with HCV in the U.S. Methods: We utilized hospitaliz...

  • Review
  • Open Access
24 Citations
6,048 Views
52 Pages

Emerging Approaches for Mitigating Biofilm-Formation-Associated Infections in Farm, Wild, and Companion Animals

  • Daniela Araújo,
  • Ana Rita Silva,
  • Rúben Fernandes,
  • Patrícia Serra,
  • Maria Margarida Barros,
  • Ana Maria Campos,
  • Ricardo Oliveira,
  • Sónia Silva,
  • Carina Almeida and
  • Joana Castro

The importance of addressing the problem of biofilms in farm, wild, and companion animals lies in their pervasive impact on animal health and welfare. Biofilms, as resilient communities of microorganisms, pose a persistent challenge in causing infect...

  • Communication
  • Open Access
3 Citations
2,293 Views
9 Pages

Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010

  • Elizabeth Ramirez-Medina,
  • Ayushi Rai,
  • Nallely Espinoza,
  • Edward Spinard,
  • Ediane Silva,
  • Leeanna Burton,
  • Jason Clark,
  • Amanda Meyers,
  • Alyssa Valladares and
  • Lauro Velazquez-Salinas
  • + 3 authors

We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G). As reported, ASFV-G-&D...

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Pathogens - ISSN 2076-0817