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Pathogens, Volume 13, Issue 4

April 2024 - 77 articles

Cover Story: HTLV-1 establishes a persistent lifelong infection by evading the host immune response, in part through the functions of the viral p12 protein. Viruses that do not express p12 (HTLV-1p12KO) cannot persistently infect macaques, and the transient depletion of monocytes prior to virus exposure allows early seroconversion, which is not sustained over time. To test whether HTLV-1 persistence depends on a monocyte reservoir or if monocyte depletion provides a transient immune evasion benefit, we simultaneously depleted NK, CD8+ T cells, and monocytes (triple depletion) prior to exposure to HTLV-1p12KO. Triple depletion resulted in the exacerbation of infection and the complete rescue of HTLV-1p12KO infectivity. This underscores the role of monocytes in orchestrating anti-viral immunity and the importance of p12 in hijacking host immunity. View this paper
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Articles (77)

  • Article
  • Open Access
1 Citations
2,391 Views
20 Pages

Clinical Strains of Mycobacterium tuberculosis Representing Different Genotype Families Exhibit Distinct Propensities to Adopt the Differentially Culturable State

  • Bhavna Gowan Gordhan,
  • Kiyasha Padarath,
  • Astika Sewcharran,
  • Amanda McIvor,
  • Michael S. VanNieuwenhze,
  • Ziyaad Waja,
  • Neil Martinson and
  • Bavesh Davandra Kana

Growing evidence points to the presence of differentially culturable tubercle bacteria (DCTB) in clinical specimens from individuals with active tuberculosis (TB) disease. These bacteria are unable to grow on solid media but can resuscitate in liquid...

  • Article
  • Open Access
2,162 Views
13 Pages

The Transmission of Campylobacter Strains in Dairy Herds in Different Housing Systems

  • Beata Wysok,
  • Małgorzata Rudowska and
  • Agnieszka Wiszniewska-Łaszczych

Cattle are frequent carriers of Campylobacter spp.; therefore, these bacteria may be transmitted to humans through meat or milk. Campylobacter spp. in raw milk derives most commonly from secondary fecal contamination during the milking process; howev...

  • Review
  • Open Access
24 Citations
5,261 Views
13 Pages

Respiratory viral coinfections are a global public health threat that poses an economic burden on individuals, families, and healthcare infrastructure. Viruses may coinfect and interact synergistically or antagonistically, or their coinfection may no...

  • Article
  • Open Access
1,729 Views
10 Pages

Epidemiology and Dynamics of BK Polyomavirus Replication after Kidney Transplantation

  • Etienne Brochot,
  • Baptiste Demey,
  • Aurélien Aubry,
  • Véronique Descamps,
  • Virginie Morel,
  • Claire Presne,
  • François Brazier and
  • François Helle

Background/Objectives: In the absence of an effective antiviral treatment for BK polyomavirus (BKPyV), a better understanding of the epidemiology and time course of BKPyV replication after kidney transplantation is needed to limit the virus’s i...

  • Systematic Review
  • Open Access
2 Citations
2,915 Views
14 Pages

Assessment of the Risk Impact of SARS-CoV-2 Infection Prevalence between Cats and Dogs in America and Europe: A Systematic Review and Meta-Analysis

  • Marcos Jessé Abrahão Silva,
  • Davi Silva Santana,
  • Marceli Batista Martins Lima,
  • Caroliny Soares Silva,
  • Letícia Gomes de Oliveira,
  • Ellerson Oliveira Loureiro Monteiro,
  • Rafael dos Santos Dias,
  • Bruna de Kássia Barbosa Pereira,
  • Paula Andresa da Silva Nery and
  • Márcio André Silva Ferreira
  • + 5 authors

The COVID-19 pandemic represented a huge obstacle for public health and demonstrated weaknesses in surveillance and health promotion systems around the world. Its etiological agent, SARS-CoV-2, of zoonotic origin, has been the target of several studi...

  • Review
  • Open Access
2 Citations
2,770 Views
13 Pages

Plasmodiophora brassicae Woronin, an obligate biotrophic soil-borne pathogen, poses a significant threat to cruciferous crops worldwide by causing the devastating disease known as clubroot. Pathogenic variability in P. brassicae populations has been...

  • Communication
  • Open Access
16 Citations
3,539 Views
12 Pages

FAM19A4 and hsa-miR124-2 Double Methylation as Screening for ASC-H- and CIN1 HPV-Positive Women

  • Cinzia Peronace,
  • Erika Cione,
  • Diana Marisol Abrego-Guandique,
  • Marco De Fazio,
  • Giuseppina Panduri,
  • Maria Cristina Caroleo,
  • Roberto Cannataro and
  • Pasquale Minchella

The DNA methylation levels of host cell genes increase with the severity of the cervical intraepithelial neoplasia (CIN) grade and are very high in cervical cancer. Our study aims to evaluate FAM19A4 and hsa-miR124-2 methylation in Atypical Squamous...

  • Article
  • Open Access
4 Citations
4,086 Views
13 Pages

The Frequency of Porcine Cysticercosis and Factors Associated with Taenia solium Infection in the Municipality of Tuchín-Córdoba, Colombia

  • Margarita M. Arango-Londoño,
  • Sara López-Osorio,
  • Fernando Rojas-Bermudéz and
  • Jenny J. Chaparro-Gutiérrez

Taeniasis and cysticercosis are parasitic infections that affect humans and pigs. Their global distribution constitutes a serious public health issue with significant implications for pork production. The purpose of this study was to evaluate the pre...

  • Article
  • Open Access
1 Citations
1,847 Views
13 Pages

Infection with Edwardsiella ictaluri, a causative agent of enteric septicemia of catfish, threatens profitable catfish production through inventory losses. We previously demonstrated that trans-cinnamaldehyde (TC) enhances the survival of catfish fol...

  • Article
  • Open Access
1 Citations
2,109 Views
15 Pages

Porphyromonas gingivalis (Pg) utilizes FimA fimbriae to colonize the gingival sulcus and evade the host immune system. The biogenesis of all FimA-related components is positively regulated by the FimS–FimR two-component system, making the FimS...

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Pathogens - ISSN 2076-0817