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Pathogens, Volume 13, Issue 4

April 2024 - 77 articles

Cover Story: HTLV-1 establishes a persistent lifelong infection by evading the host immune response, in part through the functions of the viral p12 protein. Viruses that do not express p12 (HTLV-1p12KO) cannot persistently infect macaques, and the transient depletion of monocytes prior to virus exposure allows early seroconversion, which is not sustained over time. To test whether HTLV-1 persistence depends on a monocyte reservoir or if monocyte depletion provides a transient immune evasion benefit, we simultaneously depleted NK, CD8+ T cells, and monocytes (triple depletion) prior to exposure to HTLV-1p12KO. Triple depletion resulted in the exacerbation of infection and the complete rescue of HTLV-1p12KO infectivity. This underscores the role of monocytes in orchestrating anti-viral immunity and the importance of p12 in hijacking host immunity. View this paper
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Articles (77)

  • Article
  • Open Access
4 Citations
2,317 Views
11 Pages

New evidence has suggested that oral and gut microflora may have significant impacts on the predisposition, development, and stability of obesity in adults over time—although less is known about this phenomenon in children. Compared with health...

  • Article
  • Open Access
8 Citations
4,229 Views
30 Pages

Isospora and Lankesterella Parasites (Eimeriidae, Apicomplexa) of Passeriform Birds in Europe: Infection Rates, Phylogeny, and Pathogenicity

  • Carina Keckeisen,
  • Alžbeta Šujanová,
  • Tanja Himmel,
  • Julia Matt,
  • Nora Nedorost,
  • Carolina R. F. Chagas,
  • Herbert Weissenböck and
  • Josef Harl

Wild birds are common hosts to numerous intracellular parasites such as single-celled eukaryotes of the family Eimeriidae (order Eucoccidiorida, phylum Apicomplexa). We investigated the infection rates, phylogeny, and pathogenicity of Isospora and La...

  • Communication
  • Open Access
2 Citations
2,835 Views
5 Pages

Bartonella henselae is associated with numerous clinical syndromes in people. Cats are the definitive hosts for B. henselae, develop high levels of bacteremia, and are associated with human infections, particularly in the presence of Ctenocephalides...

  • Article
  • Open Access
6 Citations
3,437 Views
10 Pages

Development of a Targeted NGS Assay for the Detection of Respiratory Pathogens including SARS-CoV-2 in Felines

  • Jobin J. Kattoor,
  • Mothomang Mlalazi-Oyinloye,
  • Sarah M. Nemser and
  • Rebecca P. Wilkes

Acute respiratory diseases in felines can be attributed to a diverse range of pathogens. The recent emergence of novel viruses, particularly SARS-CoV-2 and its variants, has also been associated with respiratory ailments in cats and other pets, under...

  • Article
  • Open Access
2 Citations
3,085 Views
13 Pages

Phylodynamic and Evolution of the Hemagglutinin (HA) and Neuraminidase (NA) Genes of Influenza A(H1N1) pdm09 Viruses Circulating in the 2009 and 2023 Seasons in Italy

  • Fabio Scarpa,
  • Leonardo Sernicola,
  • Stefania Farcomeni,
  • Alessandra Ciccozzi,
  • Daria Sanna,
  • Marco Casu,
  • Marco Vitale,
  • Alessia Cicenia,
  • Marta Giovanetti and
  • Chiara Romano
  • + 3 authors

The influenza A(H1N1) pdm09 virus, which emerged in 2009, has been circulating seasonally since then. In this study, we conducted a comprehensive genome-based investigation to gain a detailed understanding of the genetic and evolutionary characterist...

  • Article
  • Open Access
2,156 Views
21 Pages

Molecular Characterization of Non-H5 and Non-H7 Avian Influenza Viruses from Non-Mallard Migratory Waterbirds of the North American Flyways, 2006–2011

  • Shahan Azeem,
  • John Baroch,
  • Deepanker Tewari,
  • Kristy L. Pabilonia,
  • Mary Killian,
  • Birgit Bradel-Tretheway,
  • Dong Sun,
  • Sara Ghorbani-Nezami and
  • Kyoung-Jin Yoon

The surveillance of migratory waterbirds (MWs) for avian influenza virus (AIV) is indispensable for the early detection of a potential AIV incursion into poultry. Surveying AIV infections and virus subtypes in understudied MW species could elucidate...

  • Review
  • Open Access
14 Citations
8,520 Views
15 Pages

Dengue’s lack of specific treatments beyond supportive care prompts a focus on uncovering additional pathophysiological factors. Dengue-associated hemophagocytic lymphohistiocytosis (HLH), characterized by dysregulated macrophage activation and...

  • Review
  • Open Access
5 Citations
6,033 Views
20 Pages

The hepatitis C virus (HCV) infection affects 58 million people worldwide. In the United States, the incidence rate of acute hepatitis C has doubled since 2014; during 2021, this increased to 5% from 2020. Acute hepatitis C is defined by any symptom...

  • Article
  • Open Access
4 Citations
2,290 Views
15 Pages

To date, there have been no DNA-based metabarcoding studies into airborne fungi in tropical Sub-Saharan Africa. In this initial study, 10 air samples were collected onto Vaseline-coated acrylic rods mounted on drones flown at heights of 15–50 m...

  • Article
  • Open Access
2 Citations
1,879 Views
9 Pages

A Set of Multiresistant Isolates of Mycoplasma bovis Subtype ST-1 with a Variable Susceptibility to Quinolones Are Also Circulating in Spain

  • Juan Carlos Corrales,
  • Antonio Sánchez,
  • Xóchitl Hernández,
  • Joaquín Amores-Iniesta,
  • Antón Esnal and
  • Christian de la Fe

Mycoplasma bovis (M. bovis) is one of the worldwide most important infectious agents involved in respiratory complex diseases (RCD). In Spain, the endemic presence of subtypes ST-2 and ST-3 with phenotypic differences linked to their susceptibility t...

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Pathogens - ISSN 2076-0817