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Pathogens, Volume 13, Issue 4

April 2024 - 77 articles

Cover Story: HTLV-1 establishes a persistent lifelong infection by evading the host immune response, in part through the functions of the viral p12 protein. Viruses that do not express p12 (HTLV-1p12KO) cannot persistently infect macaques, and the transient depletion of monocytes prior to virus exposure allows early seroconversion, which is not sustained over time. To test whether HTLV-1 persistence depends on a monocyte reservoir or if monocyte depletion provides a transient immune evasion benefit, we simultaneously depleted NK, CD8+ T cells, and monocytes (triple depletion) prior to exposure to HTLV-1p12KO. Triple depletion resulted in the exacerbation of infection and the complete rescue of HTLV-1p12KO infectivity. This underscores the role of monocytes in orchestrating anti-viral immunity and the importance of p12 in hijacking host immunity. View this paper
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Articles (77)

  • Communication
  • Open Access
6 Citations
2,436 Views
10 Pages

Seroprevalence and Risk Factors Associated with Phleboviruses and Crimean–Congo Hemorrhagic Fever Virus among Blood Donors in Central Tunisia

  • Rym Ayari,
  • Houda Chaouch,
  • Stephen Findlay-Wilson,
  • Wissem Hachfi,
  • Nadia Ben Lasfar,
  • Foued Bellazreg,
  • Stuart Dowall,
  • Neila Hannachi and
  • Amel Letaief

The aim of this study was to determine the prevalence of six viruses, from two families of the order Bunyavirales, in the general population of central Tunisia. Sera collected from 377 asymptomatic blood donors were serologically assayed for Rift Val...

  • Article
  • Open Access
2 Citations
2,509 Views
15 Pages

Dermanyssus gallinae, the poultry red mite (PRM), is the most prevalent and harmful ectoparasite of laying hens globally. Although prevalence and risk factor studies can help veterinarians make decisions regarding farm treatments, relevant data are s...

  • Review
  • Open Access
23 Citations
5,688 Views
11 Pages

Exploring Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli in Food-Producing Animals and Animal-Derived Foods

  • Laryssa Freitas Ribeiro,
  • Natália Maramarque Nespolo,
  • Gabriel Augusto Marques Rossi and
  • John Morris Fairbrother

Antimicrobials serve as crucial treatments in both veterinary and human medicine, aiding in the control and prevention of infectious diseases. However, their misuse or overuse has led to the emergence of antimicrobial resistance, posing a significant...

  • Article
  • Open Access
2 Citations
2,055 Views
11 Pages

Molecular Detection of HPV, EBV, HSV-1, HCMV, and H. pylori Pathogens: An Evaluation among Polish Children with Molar Incisor Hypomineralization (MIH)

  • Wojciech Tynior,
  • Agata Świętek,
  • Dorota Hudy,
  • Danuta Ilczuk-Rypuła and
  • Joanna Katarzyna Strzelczyk

Molar incisor hypomineralization (MIH) is a congenital disorder of the enamel tissue, characterized by a quantitative deficiency. In childhood, infections such as EBV, HSV-1, HCMV, or H. pylori may occur and cause various diseases. This study aimed t...

  • Article
  • Open Access
2,522 Views
12 Pages

Trends in Non-Tuberculous Mycobacterial Lung Disease and Treatment Outcomes in a Low-Tuberculosis Prevalence Setting: A Retrospective Analysis

  • Biplob Kumar Mohanty,
  • Tomas Mikal Lind Eagan,
  • Bernt Bøgvald Aarli,
  • Dag Harald Skutlaberg and
  • Tehmina Mustafa

Background: Information on the management of non-tuberculous mycobacterial (NTM) lung infection and disease is scarce. The aim of this study was to investigate the trends in NTM lung infections, and the factors associated with the initiation of treat...

  • Article
  • Open Access
1 Citations
2,591 Views
12 Pages

Staphylococcus hsinchuensis sp. nov., Isolated from Soymilk

  • Yu-Ting Wang,
  • Yu-Chun Lin,
  • Yi-Huei Hsieh,
  • Yu-Tzu Lin,
  • Moriyuki Hamada,
  • Chih-Chieh Chen,
  • Jong-Shian Liou,
  • Ai-Yun Lee,
  • Wei-Ling Zhang and
  • Yung-Tsung Chen
  • + 1 author

A novel coagulase-negative Staphylococcus strain (H164T) was isolated from soymilk in Taiwan. Comparative sequence analysis of the 16S rRNA gene revealed that the H164T strain is a member of the genus Staphylococcus. We used multilocus sequence analy...

  • Article
  • Open Access
7 Citations
4,937 Views
11 Pages

Antimicrobial Activity of Methylene Blue Associated with Photodynamic Therapy: In Vitro Study in Multi-Species Oral Biofilm

  • Bruno Bueno-Silva,
  • Javier Parma-Garcia,
  • Lucio Frigo,
  • Lina J. Suárez,
  • Tatiane Tiemi Macedo,
  • Fábio Hideaki Uyeda,
  • Marcelo Augusto Ruiz da Cunha Melo,
  • Roberto Sacco,
  • Carlos Fernando Mourão and
  • Magda Feres
  • + 2 authors

The control of infectious diseases caused by biofilms is a continuing challenge for researchers due to the complexity of their microbial structures and therapeutic implications. Photodynamic therapy as an adjunctive anti-infective treatment has been...

  • Article
  • Open Access
14 Citations
2,650 Views
16 Pages

Porcine respiratory coronavirus (PRCoV), porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), and pseudorabies virus (PRV) are significant viruses causing respiratory diseases in pigs. Sick pigs exhibit similar cl...

  • Review
  • Open Access
8 Citations
3,331 Views
12 Pages

Chronic Hepatitis C Virus Infection, Extrahepatic Disease and the Impact of New Direct-Acting Antivirals

  • Nahum Méndez-Sánchez,
  • Carlos E. Coronel-Castillo and
  • Mariana Michelle Ramírez-Mejía

Chronic hepatitis C virus infection is an important cause of liver cirrhosis, hepatocellular carcinoma and death. Furthermore, it is estimated that about 40–70% of patients develop non-hepatic alterations in the course of chronic infection. Suc...

  • Article
  • Open Access
5 Citations
2,327 Views
16 Pages

Descriptive Epidemiology of Pathogens Associated with Acute Respiratory Infection in a Community-Based Study of K–12 School Children (2015–2023)

  • Cristalyne Bell,
  • Maureen Goss,
  • Derek Norton,
  • Shari Barlow,
  • Emily Temte,
  • Cecilia He,
  • Caroline Hamer,
  • Sarah Walters,
  • Alea Sabry and
  • Kelly Johnson
  • + 3 authors

School-based outbreaks often precede increased incidence of acute respiratory infections in the greater community. We conducted acute respiratory infection surveillance among children to elucidate commonly detected pathogens in school settings and th...

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Pathogens - ISSN 2076-0817