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Pathogens, Volume 13, Issue 10

October 2024 - 96 articles

Cover Story: A. fumigatus (Af) and P. aeruginosa (Pa) are pathogens in cystic fibrosis (CF) lungs. We studied their interactions and Af antifungal susceptibility, with RPMI medium (no Fe), as in standard susceptibility tests. We also studied microbial interaction in synthetic sputum medium (SSPM)(contains Fe++) to mimic CF lung milieu. Pa strain PA14 and siderophore mutant filtrate, in RPMI or SSPM, were compared for Af biofilm inhibition. SSPM enhanced Pa and Af growth and production of Pa molecules pyoverdines (pyov), phenazines, and rhamnolipids (rl). Af was more susceptible to the molecules in SSPM, but SSPM interfered with pyov susceptibility. Studies with the mutant show the reduced activity of pyov in SSPM is compensated by more production of other anti-fungal molecules: rl, phenazines and PQS, and higher Af sensitivity to them. Thus, SSPM better defines intermicrobial competition in CF lungs. View this paper
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Articles (96)

  • Article
  • Open Access
6 Citations
5,707 Views
27 Pages

Immunoinformatics Design of a Multiepitope Vaccine (MEV) Targeting Streptococcus mutans: A Novel Computational Approach

  • Romen Singh Naorem,
  • Bandana Devi Pangabam,
  • Sudipta Sankar Bora,
  • Csaba Fekete and
  • Anju Barhai Teli

21 October 2024

Dental caries, a persistent oral health challenge primarily linked to Streptococcus mutans, extends its implications beyond dental decay, affecting over 4 billion individuals globally. Despite its historical association with childhood, dental caries...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,845 Views
17 Pages

Interleukin-1 Beta rs16944 and rs1143634 and Interleukin-6 Receptor rs12083537 Single Nucleotide Polymorphisms as Potential Predictors of COVID-19 Severity

  • Inas A. Ahmed,
  • Taghrid G. Kharboush,
  • Hiba S. Al-Amodi,
  • Hala F. M. Kamel,
  • Ehab Darwish,
  • Asmaa Mosbeh,
  • Hossam A. Galbt,
  • Amal M. Abdel-Kareim and
  • Shimaa Abdelsattar

21 October 2024

Host genetic variation has been recognized as a key predictor of diverse clinical sequelae among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients. Insights into the link between the Interleukin-6 receptor (IL-6R) and Int...

  • Article
  • Open Access
1 Citations
1,618 Views
13 Pages

20 October 2024

Economic, social, and environmental sustainability are the results of efforts aiming to improve all aspects of milk production, respecting animal welfare and improving herd health. An epidemiological study was designed to assess the role of contagiou...

  • Brief Report
  • Open Access
1,571 Views
9 Pages

Effectiveness of an Infection Control Program Among the Ysleta del Sur Pueblo in Preventing COVID-19-Related Hospitalizations and Deaths

  • Cameron M. Torres,
  • Victoria Aparicio,
  • Gabriela Calzada,
  • Ascension Mena and
  • Charles T. Spencer

19 October 2024

In response to the SARS-CoV-2 pandemic, the United States declared a state of emergency and implemented large-scale shutdowns and public health initiatives to prevent overwhelming public resources. The success of these prevention methods remains unre...

  • Article
  • Open Access
1 Citations
2,056 Views
11 Pages

Escherichia coli Occurrence and Antimicrobial Resistance in a Swine Slaughtering Process

  • Aryele Nunes da Cruz Encide Sampaio,
  • Evelyn Fernanda Flores Caron,
  • Camila Koutsodontis Cerqueira-Cézar,
  • Lára Cristina Bastos Juliano,
  • Leonardo Ereno Tadielo,
  • Patrícia Regina Lopes Melo,
  • Janaína Prieto de Oliveira,
  • José Carlos de Figueiredo Pantoja,
  • Otávio Augusto Martins and
  • Luís Augusto Nero
  • + 2 authors

19 October 2024

The swine production chain can be a reservoir of antimicrobial-resistant Escherichia coli, which transfers resistance genes to other bacteria, serving as an important biomarker in the One Health approach. This study aimed to identify the frequency an...

  • Article
  • Open Access
3 Citations
1,872 Views
12 Pages

HEV in Blood Donors in Switzerland: The Route to Safe Blood Products

  • Mauro Serricchio,
  • Peter Gowland,
  • Nadja Widmer,
  • Martin Stolz and
  • Christoph Niederhauser

18 October 2024

The hepatitis E virus (HEV) is an emerging infectious disease with zoonotic potential, causing acute hepatitis in humans. Infections in healthy individuals are often acute, self-limiting and asymptomatic, thus leading to the underdiagnosis of HEV inf...

  • Article
  • Open Access
2,714 Views
16 Pages

First Report of Trypanosoma vivax (Duttonella), Babesia bovis and Babesia bigemina DNA in Cattle from the Galapagos Islands, Ecuador, and Its Relationship with Anaplasma marginale

  • María Augusta Chávez-Larrea,
  • Cristina Cholota-Iza,
  • Michelle Yugcha-Diaz,
  • Jorge Ron-Román,
  • Freddy Proaño-Pérez,
  • Alicia Maya-Delgado,
  • Jimmy Jumbo-Moreira,
  • Armando Reyna-Bello and
  • Claude Saegerman

18 October 2024

Bovine trypanosomoses, caused by Trypanosoma vivax, is a disease present in African and South American countries. This haemoflagellate protozoan parasite, as well as Anaplasma marginale and Babesia spp., are microorganisms that have a blood tropism,...

  • Review
  • Open Access
13 Citations
5,970 Views
24 Pages

18 October 2024

Viral haemorrhagic fevers encompass a diverse group of severe, often life-threatening illnesses caused by viruses from multiple families, including Arenaviridae, Filoviridae, Flaviviridae, Hantaviridae, Nairoviridae, Peribunyaviridae, and Phenuivirid...

  • Article
  • Open Access
2 Citations
2,523 Views
15 Pages

Genomic Analysis of Aeromonas salmonicida ssp. salmonicida Isolates Collected During Multiple Clinical Outbreaks Supports Association with a Single Epidemiological Unit

  • Konrad Wojnarowski,
  • Paulina Cholewińska,
  • Peter Steinbauer,
  • Tobias Lautwein,
  • Wanvisa Hussein,
  • Lisa-Marie Streb and
  • Dušan Palić

17 October 2024

Outbreaks of furunculosis cause significant losses in salmonid aquaculture worldwide. With a recent rise in antimicrobial resistance, regulatory measures to minimize the use of antibiotics in animal husbandry, including aquaculture, have increased sc...

  • Article
  • Open Access
3 Citations
4,532 Views
13 Pages

Cats: The New Challenge for Rabies Control in the State of Yucatan, Mexico

  • Aurea Mariana Salgado-Cardoso,
  • José Ignacio Olave-Leyva,
  • Ivonne Morales,
  • Alvaro Aguilar-Setién,
  • Irma López-Martínez and
  • Nidia Aréchiga-Ceballos

16 October 2024

The growing population in Yucatan has led to the expansion of construction in the Mayan jungle for tourist spaces, residential areas, and agriculture. Recently, rabies cases in cats (Felis catus) have increased in the state. This study aimed to perfo...

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Pathogens - ISSN 2076-0817