Host-Pathogen Interactions during Pathogenic Human Coronavirus Infection: 2nd Edition

Dear Colleagues,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, a causative agent of coronavirus disease 2019 (COVID-19)), is an enveloped virus responsible for the current never-ending pandemic, which began when the virus emerged in December 2019 in Wuhan, China. SARS-CoV-2 spreads from human to human through aerosol and respiratory droplet-based virus transmission. SARS-CoV-2 contains a non-segmented, positive-sense, single-strand RNA genome. With this genome, two-thirds of viral RNA is translated into large polyproteins, and a discontinuous transcription process transcribes the remainder of the viral genome into a nested set of subgenomic mRNAs, thus making it unique. Respiratory viruses appear to be diverse in cellular tropism, resulting in differences in virus-induced pathobiology, e.g., respiratory syncytial virus causes bronchiolitis, but SARS-COV-2 primarily causes pneumonia. Unlike many respiratory viruses, SARS-CoV-2 causes a systemic infection, resulting in multiorgan infection and severe pathophysiology.

This Special Issue will cover a broad understanding of SARS-CoV-2 infection, including cell tropism, strain and variants, pathophysiology, ARDS, vaccine and therapeutics, vaccine injury, treatment, animal models, viral protein characterization, genome, immune response, cytoskeletal signaling, and the convalescent stage of SARS-CoV-2 infection.

Dr. Masfique Mehedi
Guest Editor

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• COVID-19
• spike
• mRNA
• goblet cell
• viremia
• pneumonia
• convalescent
• antibody
• transmission

• Host-Pathogen Interactions during Pathogenic Human Coronavirus Infection in Pathogens (4 articles)