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Pathogens, Volume 10, Issue 7

July 2021 - 133 articles

Cover Story: Francisella tularensis (Ft) is a Tier 1 Select Agent of concern for biodefense for which there is no licensed vaccine. Herein, the Ft transporters, FptA and FptF, are evaluated as targets for attenuating mutations in Ft LVS. ΔfptA and ΔfptF mutant strains are attenuated and confer protection against lethal challenge in the mouse model. Furthermore, the data support roles for both transporters in modulating the host immune response to promote Ft’s full virulence. The results support a fundamental requirement for FptA and FptF in the pathogenesis of Ft and their potential as targets in Ft vaccine development. View this paper.
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Articles (133)

  • Systematic Review
  • Open Access
24 Citations
7,815 Views
31 Pages

Models for Studying the Distribution of Ticks and Tick-Borne Diseases in Animals: A Systematic Review and a Meta-Analysis with a Focus on Africa

  • Olivier M. Zannou,
  • Achille S. Ouedraogo,
  • Abel S. Biguezoton,
  • Emmanuel Abatih,
  • Marco Coral-Almeida,
  • Souaïbou Farougou,
  • Kouassi Patrick Yao,
  • Laetitia Lempereur and
  • Claude Saegerman

Ticks and tick-borne diseases (TTBD) are constraints to the development of livestock and induce potential human health problems. The worldwide distribution of ticks is not homogenous. Some places are ecologically suitable for ticks but they are not i...

  • Article
  • Open Access
3 Citations
4,944 Views
9 Pages

The Autofluorescence Patterns of Acanthamoeba castellanii, Pseudomonas aeruginosa and Staphylococcus aureus: Effects of Antibiotics and Tetracaine

  • Hari Kumar Peguda,
  • Saabah B. Mahbub,
  • Tashi Doma Sherpa,
  • Dinesh Subedi,
  • Abbas Habibalahi,
  • Ayad G. Anwer,
  • Zi Gu,
  • Mark D. P. Willcox,
  • Ewa M. Goldys and
  • Nicole A. Carnt

Acanthamoeba Keratitis (AK) can lead to substantial vision loss and morbidity among contact lens wearers. Misdiagnosis or delayed diagnosis is a major factor contributing to poor outcomes of AK. This study aimed to assess the effect of two antibiotic...

  • Article
  • Open Access
2 Citations
3,137 Views
10 Pages

Clinical, Radiological and Functional Characteristics of Pulmonary Diseases among HTLV-1 Infected Patients without Prior Active Tuberculosis Infection

  • Rodrigo Cachay,
  • Marcela Gil-Zacarias,
  • Takashi Watanabe-Tejada,
  • Alvaro Schwalb,
  • Fernando Mejía,
  • Oscar Gayoso and
  • Eduardo Gotuzzo

The lifelong infection with the human T lymphotropic virus type 1 (HTLV-1) has been associated with a variety of clinical manifestations; one of the less-explored is HTLV-1-associated pulmonary disease. Imaging of lung damage caused by the HTLV-1 hyp...

  • Communication
  • Open Access
27 Citations
5,012 Views
8 Pages

This study investigated the causative agent of a haemorrhagic fever epidemic in Gedaref state, south-east Sudan. Six cases of febrile illness with haemorrhagic manifestations presented at outpatient health-clinics. Blood samples were collected from t...

  • Article
  • Open Access
8 Citations
3,616 Views
16 Pages

Antistaphylococcal Activity of the FtsZ Inhibitor C109

  • Gabriele Trespidi,
  • Viola Camilla Scoffone,
  • Giulia Barbieri,
  • Federica Marchesini,
  • Aseel Abualshaar,
  • Tom Coenye,
  • Francesca Ungaro,
  • Vadim Makarov,
  • Roberta Migliavacca and
  • Edda De Rossi
  • + 1 author

Staphylococcus aureus infections represent a great concern due to their versatility and involvement in different types of diseases. The shortage of available clinical options, especially to treat multiresistant strains, makes the discovery of new eff...

  • Review
  • Open Access
13 Citations
6,178 Views
15 Pages

The process of neuroinflammation contributes to the pathogenic mechanism of many neurodegenerative diseases. The deleterious attributes of neuroinflammation involve aberrant and uncontrolled activation of glia, which can result in damage to proximal...

  • Article
  • Open Access
4 Citations
3,049 Views
12 Pages

Evaluation of HPV-Related Biomarkers in Anal Cytological Samples from HIV-Uninfected and HIV-Infected MSM

  • Francesca Rollo,
  • Alessandra Latini,
  • Massimo Giuliani,
  • Amalia Giglio,
  • Maria Gabriella Donà and
  • Maria Benevolo

Men who have sex with men (MSM) harbor the highest risk for anal carcinoma, mainly caused by Human Papillomavirus (HPV). The use of HPV-related biomarkers in the screening for this neoplasia is still debated. We assessed the association between high-...

  • Review
  • Open Access
17 Citations
21,216 Views
22 Pages

Zoonotic Malaria: Non-Laverania Plasmodium Biology and Invasion Mechanisms

  • Jing-Wen Hang,
  • Farhana Tukijan,
  • Erica-Qian-Hui Lee,
  • Shifana Raja Abdeen,
  • Yaw Aniweh and
  • Benoit Malleret

Malaria, which is caused by Plasmodium parasites through Anopheles mosquito transmission, remains one of the most life-threatening diseases affecting hundreds of millions of people worldwide every year. Plasmodium vivax, which accounts for the majori...

  • Brief Report
  • Open Access
3 Citations
3,692 Views
6 Pages

Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis

  • Domenico Umberto De Rose,
  • Fiammetta Piersigilli,
  • Bianca Maria Goffredo,
  • Olivier Danhaive,
  • Andrea Dotta and
  • Cinzia Auriti

Candida parapsilosis infections are increasingly reported in preterm neonates, but the optimal treatment remains uncertain. We report the clinical history of an extremely preterm neonate, who developed a devastating skin necrosis due to terlipressin...

  • Article
  • Open Access
6 Citations
5,834 Views
12 Pages

An Investigation of the Relationship between Cyniclomyces guttulatus and Rabbit Diarrhoea

  • Tuanyuan Shi,
  • Xinlei Yan,
  • Hongchao Sun,
  • Yuan Fu,
  • Lili Hao,
  • Yongxue Zhou,
  • Yan Liu,
  • Wenying Han,
  • Guolian Bao and
  • Xun Suo

Cyniclomyces guttulatus is usually recognised as an inhabitant of the gastrointestinal (GI) tract in rabbits. However, large numbers of C. guttulatus are often detected in the faeces of diarrhoeic rabbits. The relationship of C. guttulatus with rabbi...

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Pathogens - ISSN 2076-0817