Epigenomes, Volume 5, Issue 1 (March 2021) – 6 articles
Cover Story (view full-size image): A human telomere consists of a tract of tandemly repeated short DNA sequences d(TTAGGG) with a single-stranded overhang that can form G-quadruplex (G4) structures. In this study, the effects of N6-methyladenine (m6dA) modification on the thermal stability of four distinct telomeric G4 structures were investigated. Circular dichroism melting analysis demonstrated that the telomeric G4 structures formed in K+ were stabilized by m6dA modifications. Moreover, the thermal stability of the telomeric G4 structure formed in Na+ changed depending on the position of m6dA modification. These results contribute to the understanding of telomere biology, which can lead to applications in anti-cancer drug development. View this paper
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