Table of Contents
Epigenomes, Volume 4, Issue 1 (March 2020) – 5 articles
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Cover Story (view full-size image) Chronic kidney injury triggers fibrotic responses that impact kidney function and requires renal [...] Read more. Chronic kidney injury triggers fibrotic responses that impact kidney function and requires renal replacement therapy. Monocytes are a key fibrotic instigator, which upon infiltrating the injured kidney differentiate into macrophages with inflammatory properties that exacerbate this fibrosis. RNA-binding proteins, such as quaking, are pivotal guides of the monocyte to pro-inflammatory macrophage transition. By co-ordinating essential pre-mRNA splicing events, they determine the transcriptome and resultant proteome of these tissue-damaging cells. The development of RNA therapeutic approaches that specifically target individual RNA-binding proteins or inhibit their capacity to differentiate could limit the progression of chronic kidney injury and potentially prevent end-stage renal disease. View this paper.