Next Article in Journal
An Epigenetics-Based Hypothesis of Autoantigen Development in Systemic Lupus Erythematosus
Next Article in Special Issue
Anticodon Wobble Uridine Modification by Elongator at the Crossroad of Cell Signaling, Differentiation, and Diseases
Previous Article in Journal
Divergent DNA Methylation Signatures of Juvenile Seedlings, Grafts and Adult Apple Trees
Previous Article in Special Issue
LncRNAs and PRC2: Coupled Partners in Embryonic Stem Cells
Open AccessReview

Role of m6A in Embryonic Stem Cell Differentiation and in Gametogenesis

The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel
*
Authors to whom correspondence should be addressed.
Epigenomes 2020, 4(1), 5; https://doi.org/10.3390/epigenomes4010005
Received: 2 February 2020 / Revised: 5 March 2020 / Accepted: 11 March 2020 / Published: 14 March 2020
The rising field of RNA modifications is stimulating massive research nowadays. m6A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser and reader proteins. m6A modification is now known to take part in diverse biological processes such as embryonic development, cell circadian rhythms and cancer stem cell proliferation. In addition, there is already firm evidence for the importance of m6A modification in stem cell differentiation and gametogenesis, both in males and females. This review attempts to summarize the important results of recent years studying the mechanism underlying stem cell differentiation and gametogenesis processes. View Full-Text
Keywords: RNA modification; N6-methyladenosine; m6A; stem cells; spermatogenesis; oogenesis RNA modification; N6-methyladenosine; m6A; stem cells; spermatogenesis; oogenesis
Show Figures

Figure 1

MDPI and ACS Style

Lasman, L.; Hanna, J.H.; Novershtern, N. Role of m6A in Embryonic Stem Cell Differentiation and in Gametogenesis. Epigenomes 2020, 4, 5.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop