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Journal of Personalized Medicine, Volume 15, Issue 4

April 2025 - 40 articles

Cover Story: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) constitute the main hepatobiliary liver cancers (HBLCs) with alarming epidemiological projections. In recent decades, alterations in gut microbiota composition, with relative mutual implications on the “gut–liver axis” and “gut–biliary axis” permeability status, have been proposed as pathogenetic deus ex machina. In patients with HCC and CC, gut-derived metabolites, including bile acids (BAs), short-chain fatty acids (SCFAs), and oxidative-stress-derived products, configure a network of mediators severely impacting the onset and progression of HBLC. In the Era of Precision Medicine, the clarification of microbiota composition and functioning in HCC and CC settings can contribute to the identification of individual signatures, potentially providing novel diagnostic markers, therapeutic approaches, and prognostic–predictive tools. View this paper
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Articles (40)

  • Article
  • Open Access
859 Views
12 Pages

Artificial Intelligence-Based Algorithm for Stent Coverage Assessments

  • Joanna Fluder-Wlodarczyk,
  • Mikhail Darakhovich,
  • Zofia Schneider,
  • Magda Roleder-Dylewska,
  • Magdalena Dobrolińska,
  • Tomasz Pawłowski,
  • Wojciech Wojakowski,
  • Pawel Gasior and
  • Elżbieta Pociask

11 April 2025

Background: Neointimal formation after stent implantation is an important prognostic factor since delayed healing may lead to stent thrombosis. In vivo, optical coherence tomography (OCT) can most precisely assess stent strut coverage. Since analyzin...

  • Article
  • Open Access
1 Citations
848 Views
19 Pages

Implementing Personalized Cancer Medicine: Insights from a Qualitative Interview Study

  • Michele Masucci,
  • Jenny Del Villar Pérez,
  • Pamela Mazzocato,
  • Ingemar Ernberg and
  • Mats Brommels

9 April 2025

Background: Personalized cancer medicine (PCM) tailors cancer treatments based on individual genetic profiles, enabling more precise and effective therapies. Despite its potential, integrating PCM into clinical practice remains challenging because of...

  • Article
  • Open Access
893 Views
11 Pages

Personalized Antithrombotic Strategies in Patients with Atrial Fibrillation Following Transcatheter Aortic Valve Replacement

  • Razan Awan,
  • Monirah A. Albabtain,
  • Aisha AlRasheedi,
  • Maha AlHarthi,
  • Zaid Alanazi and
  • Amr A. Arafat

9 April 2025

Background: Atrial fibrillation (AF) is prevalent in patients undergoing transcatheter aortic valve replacement (TAVR). However, the optimal antithrombotic strategy tailored to individual patient profiles remains unclear. This study aims to evaluate...

  • Review
  • Open Access
1,037 Views
14 Pages

Pregnancy-Related Heart Disease in the Emergency Department

  • Nicole R. Hodgson,
  • Rachel A. Lindor,
  • Jessica Monas,
  • Kimberly Heller,
  • Patrick Kishi,
  • Aaron Thomas,
  • Cody Petrie,
  • Lauren B. Querin,
  • Andrej Urumov and
  • David S. Majdalany

8 April 2025

Pregnancy induces significant physiologic changes that impact the cardiovascular system, potentially exacerbating pre-existing cardiac conditions or precipitating new illnesses. Pregnant patients with cardiac emergencies pose unique challenges, as st...

  • Article
  • Open Access
1,111 Views
19 Pages

8 April 2025

Background: Dental anxiety is a significant barrier to dental care, leading to avoidance behaviors and compromised oral health. This study aimed to analyze fear and anxiety during dental hygiene visits with Guided Biofilm Therapy (GBT), focusing on g...

  • Systematic Review
  • Open Access
1 Citations
2,771 Views
15 Pages

A Systematic Review and Meta-Analysis Association Between Periodontitis and Age-Related Macular Degeneration: Potential for Personalized Approach

  • Sophie Boberg-Ans,
  • Frederikke Arnold-Vangsted,
  • Anna Bonde Scheel-Bech,
  • Lars Christian Boberg-Ans,
  • Andreas Arnold-Vangsted,
  • Christian Jakobsen,
  • Kasper Stokbro and
  • Yousif Subhi

5 April 2025

Background/Objectives: Periodontitis is a chronic inflammatory disease that leads to systemic low-grade inflammation. Systemic low-grade inflammation has been found in patients with age-related macular degeneration (AMD). In this systematic review an...

  • Article
  • Open Access
1,249 Views
18 Pages

Exploring the Clinical Workflow in Pharmacogenomics Clinics: An Observational Study

  • Nicole Keuler,
  • Jane McCartney,
  • Renier Coetzee and
  • Rustin Crutchley

5 April 2025

Background: Pharmacogenomics (PGx) is the future of healthcare and implementation is being driven by increasing evidence. Understanding the workflow in a PGx clinic provides insight into the development and implementation of PGx services. It consider...

  • Article
  • Open Access
2 Citations
863 Views
13 Pages

4 April 2025

Background/Objectives: Gastric cancer treatments can lead to significant alterations to patients’ gastrointestinal microbiome. However, differences in microbial impacts between gastrectomy and endoscopic submucosal dissection (ESD) remain under...

  • Article
  • Open Access
2 Citations
2,764 Views
11 Pages

Pulsed Electromagnetic Field Therapy Alters the Genomic Profile of Bladder Cancer Cell Line HT-1197

  • Maxwell Sandberg,
  • Wyatt Whitman,
  • Randall Bissette,
  • Christina Ross,
  • Matvey Tsivian and
  • Stephen J. Walker

4 April 2025

Background/Objectives: Pulsed electromagnetic field (PEMF) therapy involves the use of magnetic waveform energy for targeted treatment delivery. This technique has shown promising results in the treatment of various cancers. Currently, treatment of b...

  • Review
  • Open Access
1,873 Views
12 Pages

Ultrafast Breast MRI: A Narrative Review

  • Ottavia Battaglia,
  • Filippo Pesapane,
  • Silvia Penco,
  • Giulia Signorelli,
  • Valeria Dominelli,
  • Luca Nicosia,
  • Anna Carla Bozzini,
  • Anna Rotili and
  • Enrico Cassano

2 April 2025

Breast magnetic resonance imaging (MRI) is considered the most effective method for detecting breast cancer due to its high sensitivity. Yet multiple factors limit its widespread use, including high direct and indirect costs, a prolonged acquisition...

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J. Pers. Med. - ISSN 2075-4426Creative Common CC BY license