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Journal of Personalized Medicine, Volume 14, Issue 5

May 2024 - 105 articles

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Cover Story: Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological and psychiatric health. It exerts a profound effect on immune cell activation and brain function, suggesting potential roles in both neuroprotection and neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation and disease progression. Additionally, CXCL8 gene polymorphisms can alter IL-8 production, leading to potential differences in disease susceptibility, progression, and severity across populations. IL-8 levels vary among neuropsychiatric conditions, demonstrating sensitivity to psychosocial stressors and disease severity. IL-8 can be detected in blood circulation, cerebrospinal fluid (CSF), and urine, making it a promising candidate for a broad-spectrum biomarker. View this paper

Articles (105)

  • Article
  • Open Access
1,583 Views
14 Pages

Automatic Classification and Visualization of Text Data on Rare Diseases

  • Luis Rei,
  • Joao Pita Costa and
  • Tanja Zdolšek Draksler

More than 7000 rare diseases affect over 400 million people, posing significant challenges for medical research and healthcare. The integration of precision medicine with artificial intelligence offers promising solutions. This work introduces a clas...

  • Review
  • Open Access
6 Citations
2,885 Views
15 Pages

Sudden Cardiac Death, Post-Mortem Investigation: A Proposing Panel of First Line and Second Line Genetic Tests

  • Fabio Del Duca,
  • Alessandro Ghamlouch,
  • Alice Chiara Manetti,
  • Gabriele Napoletano,
  • Elena Sonnini,
  • Biancamaria Treves,
  • Alessandra De Matteis,
  • Raffaele La Russa,
  • Mary N. Sheppard and
  • Vittorio Fineschi
  • + 1 author

Investigating the causes of Sudden cardiac death (SCD) is always difficult; in fact, genetic cardiac conditions associated with SCD could be “silent” even during autopsy investigation. In these cases, it is important to exclude other aeti...

  • Article
  • Open Access
16 Citations
3,215 Views
13 Pages

Ellipsoid Zone Integrity and Visual Function in Dry Age-Related Macular Degeneration

  • Sari Yordi,
  • Yavuz Cakir,
  • Gagan Kalra,
  • Hasan Cetin,
  • Ming Hu,
  • Joseph Abraham,
  • Jamie Reese,
  • Sunil K. Srivastava and
  • Justis P. Ehlers

In this longitudinal retrospective image analysis, conducted on patients diagnosed with dry age-related macular degeneration (AMD) and 5 years of follow-up imaging data, the study aimed to investigate the relationship between ellipsoid zone (EZ) inte...

  • Article
  • Open Access
1,693 Views
12 Pages

A Modern Multidisciplinary Method to Characterize Natural White Spot Lesions with 2D and 3D Assessments: A Preliminary Study

  • Flavia Vitiello,
  • Giulia Orilisi,
  • Valentina Notarstefano,
  • Michele Furlani,
  • Nicole Riberti,
  • Tiziano Bellezze,
  • Florence Carrouel,
  • Angelo Putignano and
  • Giovanna Orsini

In this preliminary study, a multidisciplinary method based on high-resolution analytical techniques (such as microcomputed tomography, Raman Microspectroscopy, scanning electron microscopy, and Vickers microhardness test) was exploited to evaluate t...

  • Article
  • Open Access
20 Citations
5,098 Views
13 Pages

Long-Term Clinical Outcomes of 3D-Printed Subperiosteal Titanium Implants: A 6-Year Follow-Up

  • Neculai Onică,
  • Dana Gabriela Budală,
  • Elena-Raluca Baciu,
  • Cezara Andreea Onică,
  • Gabriela Luminița Gelețu,
  • Alice Murariu,
  • Mihail Balan,
  • Mihaela Pertea and
  • Carmen Stelea

As an alternative to regenerative therapies, numerous authors have recently proposed bringing back subperiosteal implants. The aim of the study was to present our clinical experience with a subperiosteal jaw implant that needs minimal bone preparatio...

  • Feature Paper
  • Article
  • Open Access
1,368 Views
13 Pages

Two-Year Outcomes for Patients with Non-ST-Elevation Acute Coronary Syndrome Treated with Magmaris and Absorb Bioresorbable Scaffolds in Large-Vessel Lesions

  • Adrian Włodarczak,
  • Piotr Rola,
  • Szymon Włodarczak,
  • Marek Szudrowicz,
  • Katarzyna Giniewicz,
  • Magdalena Łanocha,
  • Joanna Jaroszewska-Pozorska,
  • Mateusz Barycki,
  • Łukasz Furtan and
  • Michalina Kędzierska
  • + 3 authors

Background: The acute coronary syndrome (ACS) continues to be a fundamental indication for revascularization by percutaneous coronary intervention (PCI). Drug-eluting stent (DES) implantation remains a part of contemporary practice but permanent cagi...

  • Article
  • Open Access
6 Citations
2,145 Views
13 Pages

Behavioral Disorders of Spatial Cognition in Patients with Mild Cognitive Impairment Due to Alzheimer’s Disease (The BDSC-MCI Project): Ecological Validity of the Corsi Learning Suvra-Span Test

  • Davide Maria Cammisuli,
  • Gloria Marchesi,
  • Virginia Bellocchio,
  • Edoardo Nicolò Aiello,
  • Barbara Poletti,
  • Federico Verde,
  • Vincenzo Silani,
  • Nicola Ticozzi,
  • Stefano Zago and
  • Teresa Difonzo
  • + 6 authors

Background: Spatial navigation deficits are reported as early symptoms of Alzheimer’s disease (AD) alongside episodic memory ones. The aim of the present study was to ascertain whether neuropsychological deficits of visuospatial long-term memor...

  • Review
  • Open Access
1 Citations
2,024 Views
15 Pages

Preferred Imaging for Target Volume Delineation for Radiotherapy of Recurrent Glioblastoma: A Literature Review of the Available Evidence

  • Francesco Cuccia,
  • Fatemeh Jafari,
  • Salvatore D’Alessandro,
  • Giuseppe Carruba,
  • Giuseppe Craparo,
  • Giovanni Tringali,
  • Livio Blasi and
  • Giuseppe Ferrera

Background: Recurrence in glioblastoma lacks a standardized treatment, prompting an exploration of re-irradiation’s efficacy. Methods: A comprehensive systematic review from January 2005 to May 2023 assessed the role of MRI sequences in recurre...

  • Review
  • Open Access
8 Citations
3,231 Views
32 Pages

Inflammation during the perioperative period of joint arthroplasty is a critical aspect of patient outcomes, influencing both the pathophysiology of pain and the healing process. This narrative review comprehensively evaluates the roles of specific c...

  • Article
  • Open Access
3 Citations
2,778 Views
11 Pages

Breast Vascularization and Its Implication in Breast Reduction and Mastopexy Surgery: Anatomical Study

  • Ainhoa Salas-López,
  • Carolina Morgado-Águila,
  • Carlos López-de-Celis,
  • Jacobo Rodríguez-Sanz,
  • Sara Ortiz-Miguel and
  • Albert Pérez-Bellmunt

(1) Background: Breast reduction is one of the most frequently performed plastic surgeries in women worldwide. The Wise pattern breast reduction is one of the most frequent skin designs for this surgery. One key point of the surgery is to preserve a...

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