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Journal of Personalized Medicine, Volume 13, Issue 5

2023 May - 176 articles

Cover Story: Personalized and human-supported digital rehabilitation for total knee replacement (TKA) has revolutionized recovery. In this study, a cohort of 127 patients participated in an app-based program backed by smart alerts and doctor involvement. The readmission rate was only 2%, with 85% of alerts preventing unnecessary consultations. The rate of adherence to the program reached 77%, and 89% of patients stated they would recommend it. This transformative approach enhances patient-reported outcomes, reduces complications and readmissions, and lowers healthcare costs. This marks a new era in TKA rehabilitation, blending advanced technology with human support for personalized and holistic recovery. View this paper
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Articles (176)

  • Review
  • Open Access
1 Citations
2,990 Views
26 Pages

Personalized Management of Sudden Death Risk in Primary Cardiomyopathies: From Clinical Evaluation and Multimodality Imaging to Ablation and Cardioverter-Defibrillator Implant

  • Davide Lazzeroni,
  • Antonio Crocamo,
  • Valentina Ziveri,
  • Maria Francesca Notarangelo,
  • Davide Rizzello,
  • Matteo Spoladori,
  • Davide Donelli,
  • Giovanna Cacciola,
  • Diego Ardissino and
  • Giovanni Peretto
  • + 1 author

Sudden cardiac death represents the leading cause of death worldwide; although the majority of sudden deaths occur in an elderly population with coronary artery disease, some occur in young and otherwise healthy individuals, as is the case of cardiom...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
5 Citations
3,452 Views
15 Pages

Association between Psychological, Biochemical and Personal Factors with the Inflammatory Marker High-Sensitive C Reactive Protein (Hs-CRP) in Mexican Healthy Population

  • Aniel Jessica Leticia Brambila-Tapia,
  • Ana Lilia Jacquez-Castañeda,
  • Laura Arely Carrillo-Delgadillo,
  • Jessica Natalia Dávila-Flores,
  • Fabiola Macías-Espinoza,
  • Saúl Ramírez-De Los Santos and
  • Itzae Adonai Gutiérrez-Hurtado

In the last decades, it has been shown that inflammatory processes play a role in the development of mental and physical problems; although some studies have researched the relationship between inflammation and psychological variables, the inclusion...

(This article belongs to the Topic Diagnosis, Management, and Prognostic Assessment of Chronic Disease)
  • Article
  • Open Access
12 Citations
5,435 Views
10 Pages

Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by patterns in which unwanted thoughts and fears are evoked as obsessions and furthermore, compulsive behaviors are provoked repeatedly, with a prevalence rate of 2% of the p...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
11 Citations
4,608 Views
32 Pages

In this article, we introduce a new approach to human movement by defining the movement as a static super object represented by a single two-dimensional image. The described method is applicable in remote healthcare applications, such as physiotherap...

(This article belongs to the Special Issue Selected Papers from the pHealth 2022 Conference, Oslo, Norway, 8–10 November 2022)
  • Article
  • Open Access
12 Citations
3,818 Views
15 Pages

Positivity and Health Locus of Control: Key Variables to Intervene on Well-Being of Cardiovascular Disease Patients

  • Bárbara Luque,
  • Naima Z. Farhane-Medina,
  • Marta Villalba,
  • Rosario Castillo-Mayén,
  • Esther Cuadrado and
  • Carmen Tabernero

Psychological well-being is a good predictor of several health outcomes in cardiovascular disease patients (adherence, quality of life, and healthy behaviors). The perception of health control and a positive orientation seem to have a beneficial effe...

(This article belongs to the Special Issue Current Challenges and Personalized Treatment in Cardiovascular Disease)
  • Brief Report
  • Open Access
4 Citations
2,454 Views
9 Pages

The Role of Myocardial Perfusion Imaging in the Prediction of Major Adverse Cardiovascular Events at 1 Year Follow-Up: A Single Center’s Experience

  • Paraskevi Zotou,
  • Aris Bechlioulis,
  • Spyridon Tsiouris,
  • Katerina K. Naka,
  • Xanthi Xourgia,
  • Konstantinos Pappas,
  • Lampros Lakkas,
  • Aidonis Rammos,
  • John Kalef-Ezra and
  • Andreas Fotopoulos
  • + 1 author

Background: Myocardial perfusion imaging via single-photon emission computed tomography (SPECT MPI) is a well-established method of diagnosing coronary artery disease (CAD). The purpose of this study was to assess the role of SPECT MPI in predicting...

(This article belongs to the Special Issue Current Challenges and Personalized Treatment in Cardiovascular Disease)
  • Article
  • Open Access
3 Citations
2,782 Views
10 Pages

Prostate Cancer Scoring Index for Risk of Progression of Radioresistant Disease

  • Eleonora Cini Tesar,
  • Ivana Mikolasevic,
  • Iva Skocilic,
  • Arnela Redjovic,
  • Damir Vucinic,
  • Jasna Marusic and
  • Gordana Djordjevic

Prostate cancer (Pca) is among the most common malignant diseases in men and the fourth leading cause of death worldwide. Surgery and radical radiotherapy (RT) remain the gold standard for the treatment of localized or locally advanced prostate cance...

(This article belongs to the Section Mechanisms of Diseases)
  • Article
  • Open Access
10 Citations
4,303 Views
13 Pages

Background: Despite the common occurrence of postoperative complications in patients with frailty syndrome, the nature and severity of this relationship remains unclear. We aimed to assess the association of frailty with possible postoperative compli...

  • Article
  • Open Access
7 Citations
2,782 Views
9 Pages

The aims of this study were to evaluate the outcomes of patients undergoing kinematic alignment (KA) robot-assisted (RA) total knee arthroplasty (TKA) with and without preoperative fixed flexion contracture (FFC) and address whether additional resect...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Systematic Review
  • Open Access
20 Citations
7,937 Views
11 Pages

Multiple General Anesthesia in Children: A Systematic Review of Its Effect on Neurodevelopment

  • Giacomo Colletti,
  • Mattia Di Bartolomeo,
  • Sara Negrello,
  • Roy G. Geronemus,
  • Bernard Cohen,
  • Luigi Chiarini,
  • Alexandre Anesi,
  • Raimondo Feminò,
  • Ilaria Mariotti and
  • Riccardo Nocini
  • + 2 authors

The effect of multiple general anesthesia (mGA) procedures administered in early life is a critical theme and has led the Food and Drug Administration (FDA) to issue an alert. This systematic review seeks to explore the potential effects on neurodeve...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
15 Citations
4,593 Views
11 Pages

Clinico-Pathological Factors Determining Recurrence of Phyllodes Tumors of the Breast: The 25-Year Experience at a Tertiary Cancer Centre

  • Baijaeek Sain,
  • Arnab Gupta,
  • Aruni Ghose,
  • Sudip Halder,
  • Vishal Mukherjee,
  • Samir Bhattacharya,
  • Radha Raman Mondal,
  • Aditya Narayan Sen,
  • Bijan Saha and
  • Stergios Boussios
  • + 1 author

Background: Phyllodes tumors (PTs) of the breast are rare fibroepithelial tumors that are generally more prone to recurrence. Aims and objectives: This study aimed to assess the clinicopathological features, diagnostic modalities, and therapeutic int...

  • Article
  • Open Access
9 Citations
3,662 Views
12 Pages

Local Treatment of Triple-Negative Breast Cancer: Is Mastectomy Superior to Breast-Conserving Surgery?

  • Alba Di Leone,
  • Antonio Franco,
  • Francesca Zotta,
  • Lorenzo Scardina,
  • Margherita Sicignano,
  • Enrico Di Guglielmo,
  • Virginia Castagnetta,
  • Stefano Magno,
  • Daniela Terribile and
  • Riccardo Masetti
  • + 2 authors

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). TNBC accounts for about 15% of breast can...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Brief Report
  • Open Access
9 Citations
4,611 Views
12 Pages

Comparing Cytology Brushes for Optimal Human Nasal Epithelial Cell Collection: Implications for Airway Disease Diagnosis and Research

  • Laura K. Fawcett,
  • Nihan Turgutoglu,
  • Katelin M. Allan,
  • Yvonne Belessis,
  • John Widger,
  • Adam Jaffe and
  • Shafagh A. Waters

Primary nasal epithelial cells and culture models are used as important diagnostic, research and drug development tools for several airway diseases. Various instruments have been used for the collection of human nasal epithelial (HNE) cells but no gl...

(This article belongs to the Section Pharmacogenetics)
  • Article
  • Open Access
4 Citations
3,658 Views
10 Pages

Background: Previous studies have investigated the safety of peripherally inserted central catheters (PICCs) in the intensive care unit (ICU). However, it remains uncertain whether PICC placement can be successfully carried out in settings with limit...

(This article belongs to the Special Issue Challenges in COVID-19 and Related Complications)
  • Article
  • Open Access
8 Citations
3,481 Views
17 Pages

Radiomics in Breast Imaging: Future Development

  • Alessandra Panico,
  • Gianluca Gatta,
  • Antonio Salvia,
  • Graziella Di Grezia,
  • Noemi Fico and
  • Vincenzo Cuccurullo

Breast cancer is the most common and most commonly diagnosed non-skin cancer in women. There are several risk factors related to habits and heredity, and screening is essential to reduce the incidence of mortality. Thanks to screening and increased a...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Article
  • Open Access
5 Citations
2,941 Views
21 Pages

Acquisition Parameters Influence Diffusion Metrics Effectiveness in Probing Prostate Tumor and Age-Related Microstructure

  • Alessandra Stella Caporale,
  • Marco Nezzo,
  • Maria Giovanna Di Trani,
  • Alessandra Maiuro,
  • Roberto Miano,
  • Pierluigi Bove,
  • Alessandro Mauriello,
  • Guglielmo Manenti and
  • Silvia Capuani

This study aimed to investigate the Diffusion-Tensor-Imaging (DTI) potential in the detection of microstructural changes in prostate cancer (PCa) in relation to the diffusion weight (b-value) and the associated diffusion length lD. Thirty-two patient...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Review
  • Open Access
11 Citations
4,324 Views
17 Pages

The Magnitude of Cardiovascular Disease Risk Factors in Seafarers from 1994 to 2021: A Systematic Review and Meta-Analysis

  • Getu Gamo Sagaro,
  • Ulrico Angeloni,
  • Claudia Marotta,
  • Giulio Nittari,
  • Giovanni Rezza,
  • Andrea Silenzi,
  • Gopi Battineni and
  • Francesco Amenta

Objectives: The incidence of acute cardiac events is one of the main reasons for medical consultation, disembarkation, repatriation, and death among seafarers at sea. Managing cardiovascular risk factors, particularly those that can be modified, is t...

(This article belongs to the Special Issue Digital Health and Telemedicine: Their Contribution to Personalized and Precision Medicine)
  • Article
  • Open Access
4 Citations
4,458 Views
14 Pages

A New Digital Method to Quantify the Effects Produced by Carriere Motion Appliance

  • Aldara Rosalía Nercellas Rodríguez,
  • Pedro Colino Gallardo,
  • Álvaro Zubizarreta-Macho,
  • Carlos Colino Paniagua,
  • Alfonso Alvarado Lorenzo and
  • Alberto Albaladejo Martínez

The aim of this study was to analyze a novel digital technique to quantify the distal tooth displacement and derotation angle produced by the Carriere Motion Appliance (CMA). Twenty-one patients with a class II molar and canine relationship underwent...

(This article belongs to the Special Issue Recent Advances in Dental Practice)
  • Article
  • Open Access
2 Citations
2,706 Views
11 Pages

(1) Background: The jejunum is primarily used for distal pancreatic stump anastomoses after central pancreatectomy (CP). The study aimed to compare duct-to-mucosa (WJ) and distal pancreatic invagination into jejunum anastomoses (PJ) after CP. (2) Met...

(This article belongs to the Section Methodology, Drug and Device Discovery)
  • Brief Report
  • Open Access
3 Citations
4,235 Views
10 Pages

Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study

  • Michael A. Turner,
  • Kristin E. Cox,
  • Nicholas Neel,
  • Siamak Amirfakhri,
  • Hiroto Nishino,
  • Bryan M. Clary,
  • Mojgan Hosseini,
  • Gopalakrishnan Natarajan,
  • Kavita Mallya and
  • Michael Bouvet
  • + 3 authors

Accurately identifying metastatic disease is critical to directing the appropriate treatment in pancreatic cancer. Mucin 5AC is overexpressed in pancreatic cancer but absent in normal pancreas tissue. The present proof-of-concept study demonstrates t...

  • Article
  • Open Access
5 Citations
2,942 Views
13 Pages

The Comparison of Predicting Factors and Outcomes of MINOCA and STEMI Patients in the 5-Year Follow-Up

  • Patryk Buller,
  • Adam Kern,
  • Maciej Tyczyński,
  • Wojciech Rosiak,
  • Włodzimierz Figatowski,
  • Robert J. Gil and
  • Jacek Bil

The long-term outcomes of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) are still not well known. This study aimed to compare the characteristics and outcomes between MINOCA and STEMI patients in a 5-year follow-...

(This article belongs to the Special Issue Personalized Medicine for Coronary Artery Disease: Diagnosis, Prevention, and Treatment)
  • Technical Note
  • Open Access
8 Citations
2,962 Views
10 Pages

The Deep-MCL Line: A Reliable Anatomical Landmark to Optimize the Tibial Cut in UKA

  • Sébastien Parratte,
  • Jeremy Daxhelet,
  • Jean-Noel Argenson and
  • Cécile Batailler

The extramedullary guides for the tibial resection during medial unicompartmental knee arthroplasty (UKA) are inaccurate, with an error risk in coronal and sagittal planes and cut thickness. It was our hypothesis that the use of anatomical landmarks...

(This article belongs to the Special Issue Cutting-Edge in Arthroplasty: Before, While and after Surgery)
  • Technical Note
  • Open Access
9 Citations
3,810 Views
9 Pages

Morphological Variation of the Mandible in the Orthognathic Population—A Morphological Study Using Statistical Shape Modelling

  • Hylke van der Wel,
  • Bingjiang Qiu,
  • Fred K. L. Spijkervet,
  • Johan Jansma,
  • Rutger H. Schepers and
  • Joep Kraeima

The aim of this study was to investigate the value of 3D Statistical Shape Modelling for orthognathic surgery planning. The goal was to objectify shape variations in the orthognathic population and differences between male and female patients by mean...

  • Review
  • Open Access
14 Citations
6,345 Views
17 Pages

Ligand-Gated Ion Channels: Prognostic and Therapeutic Implications for Gliomas

  • Grace Hey,
  • Rohan Rao,
  • Ashley Carter,
  • Akshay Reddy,
  • Daisy Valle,
  • Anjali Patel,
  • Drashti Patel,
  • Brandon Lucke-Wold,
  • Daniel Pomeranz Krummel and
  • Soma Sengupta

Gliomas are common primary brain malignancies that remain difficult to treat due to their overall aggressiveness and heterogeneity. Although a variety of therapeutic strategies have been employed for the treatment of gliomas, there is increasing evid...

(This article belongs to the Section Mechanisms of Diseases)
  • Perspective
  • Open Access
27 Citations
6,260 Views
15 Pages

The Changing Environment in Postgraduate Education in Orthopedic Surgery and Neurosurgery and Its Impact on Technology-Driven Targeted Interventional and Surgical Pain Management: Perspectives from Europe, Latin America, Asia, and The United States

  • Kai-Uwe Lewandrowski,
  • John C. Elfar,
  • Zong-Ming Li,
  • Benedikt W. Burkhardt,
  • Morgan P. Lorio,
  • Peter A. Winkler,
  • Joachim M. Oertel,
  • Albert E. Telfeian,
  • Álvaro Dowling and
  • Pietro Novellino
  • + 16 authors

Personalized care models are dominating modern medicine. These models are rooted in teaching future physicians the skill set to keep up with innovation. In orthopedic surgery and neurosurgery, education is increasingly influenced by augmented reality...

  • Article
  • Open Access
2 Citations
3,019 Views
15 Pages

Perceptions and Usability of PREVENTION: A Breast Cancer Risk Assessment e-Platform

  • Samar Attieh,
  • Marika Monarque,
  • Andrew Durand,
  • Saima Ahmed,
  • Bartha M. Knoppers,
  • Jacques Simard and
  • Carmen G. Loiselle

Background: The PREVENTION e-platform was developed to provide accessible and evidence-based health information tailored to different Breast Cancer (BC) risk levels. The demonstration study objectives were to (1) assess the usability and perceived im...

  • Article
  • Open Access
3 Citations
2,888 Views
11 Pages

The standard treatment of locally advanced rectal cancer is neoadjuvant chemoradiotherapy before surgery. For those patients experiencing a complete clinical response after the treatment, a watch-and-wait strategy with close monitoring may be practic...

(This article belongs to the Section Omics/Informatics)
  • Review
  • Open Access
17 Citations
5,044 Views
13 Pages

Background: The emergency department (ED) is often overburdened, due to the high influx of patients and limited availability of attending physicians. This situation highlights the need for improvement in the management of, and assistance provided in...

(This article belongs to the Collection Advances of Emergency and Intensive Care)
  • Case Report
  • Open Access
6 Citations
4,708 Views
17 Pages

Systematic Literature Review and Early Benefit of Cochlear Implantation in Two Pediatric Auditory Neuropathy Cases

  • Thomas Keintzel,
  • Tobias Raffelsberger,
  • Lisa Niederwanger,
  • Gina Gundacker and
  • Thomas Rasse

Approximately 1 in 10 children with hearing loss is affected by auditory neuropathy spectrum disorder (ANSD). People who have ANSD usually have great difficulty understanding speech or communicating. However, it is possible for these patients to have...

(This article belongs to the Special Issue Personalized Medicine in Otolaryngology: Special Topic Otology)
  • Article
  • Open Access
8 Citations
2,056 Views
12 Pages

Sentinel Lymph Node Impact on the Quality of Life of Patients with Endometrial Cancer

  • Virginia García-Pineda,
  • Alicia Hernández,
  • Sonia Garrido-Mallach,
  • Elena Rodríguez-González,
  • María Alonso-Espías,
  • Myriam Gracia,
  • Rocío Arnedo and
  • Ignacio Zapardiel

Objective: Given the improvement in the surgical treatment of endometrial cancer with the inclusion of sentinel lymph node biopsy (SLNB), our aim was to evaluate the impact of this minimally invasive and tailored nodal assessment on patients’ q...

(This article belongs to the Special Issue Novel and Personalized Treatment Concepts in Gynecologic Cancer)
  • Article
  • Open Access
11 Citations
4,216 Views
12 Pages

Comparison of Anatomical Preformed Titanium Implants and Patient-Specific CAD/CAM Implants in the Primary Reconstruction of Isolated Orbital Fractures—A Retrospective Study

  • Sebastian Pietzka,
  • Markus Wenzel,
  • Karsten Winter,
  • Frank Wilde,
  • Alexander Schramm,
  • Marcel Ebeling,
  • Robin Kasper,
  • Mario Scheurer and
  • Andreas Sakkas

Background/Aim: Reconstruction of the fractured orbit remains a challenge. The aim of this study was to compare anatomical preformed titanium orbital implants with patient-specific CAD/CAM implants for precision and intraoperative applicability. Mate...

(This article belongs to the Special Issue Computer Assisted Maxillo-Facial Surgery)
  • Review
  • Open Access
58 Citations
10,604 Views
15 Pages

Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation

  • Umit M. Sahiner,
  • Mattia Giovannini,
  • Maria M. Escribese,
  • Giovanni Paoletti,
  • Enrico Heffler,
  • Montserrat Alvaro Lozano,
  • Domingo Barber,
  • Giorgio Walter Canonica and
  • Oliver Pfaar

Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Feature Paper
  • Article
  • Open Access
12 Citations
3,939 Views
11 Pages

Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes

  • Emyal Alyaydin,
  • Juergen Reinhard Sindermann,
  • Jeanette Köppe,
  • Joachim Gerss,
  • Patrik Dröge,
  • Thomas Ruhnke,
  • Christian Günster,
  • Holger Reinecke and
  • Jannik Feld

Background: Depression and anxiety (DA) are common mental disorders in patients with chronic diseases, but the research regarding their prevalence in heart transplantation (HTx) is still limited. Methods: We performed an analysis of the prevalence an...

(This article belongs to the Special Issue Current Challenges and Personalized Treatment in Cardiovascular Disease)
  • Brief Report
  • Open Access
13 Citations
5,109 Views
9 Pages

Introduction: Increased red blood cell distribution width (RDW) has been reported to be related to underlying chronic inflammation. Our aim is to investigate the relationship of different complete blood count (CBC) parameters such as hemoglobin level...

(This article belongs to the Topic Diagnosis, Management, and Prognostic Assessment of Chronic Disease)
  • Communication
  • Open Access
10 Citations
3,514 Views
13 Pages

Introducing Radiotherapy in Metastatic Merkel Cell Carcinoma Patients with Limited Progression on Avelumab: An Effective Step against Primary and Secondary Immune Resistance?

  • Gianluca Ferini,
  • Valentina Zagardo,
  • Paola Critelli,
  • Anna Santacaterina,
  • Serena Sava,
  • Mandara Muralidhar Harikar,
  • Tejas Venkataram,
  • Giuseppe Emmanuele Umana,
  • Anna Viola and
  • Stefano Forte
  • + 1 author

Purpose: To investigate the ability of radiotherapy (RT) to prolong progression-free survival (PFS) and to report treatment-related toxicities among oligoprogressive metastatic Merkel cell carcinoma (mMCC) patients on avelumab. Methods: We retrospect...

(This article belongs to the Special Issue Cancer Immunotherapy: Current Advancements and Future Perspectives)
  • Article
  • Open Access
4 Citations
6,621 Views
13 Pages

Comparative Evaluation of Sildenafil Citrate and Estrogen as an Adjuvant Therapy for Treatment of Unexplained Infertility in Women

  • Ahmed E. Altyar,
  • Marian S. Boshra,
  • Ahmed Essam Abou Warda,
  • Sherwet M. Shawkey,
  • Sara Abdallah Mohamed Salem,
  • Rania M. Sarhan and
  • Neven Sarhan

Background: Uterine blood flow determines endometrial thickness. This study examined how vaginal sildenafil citrate and estradiol valerate altered endometrial thickness, blood flow, and fertility in infertile women. Methods: This study observed 148 i...

(This article belongs to the Special Issue Obstetrics and Gynecology and Women's Health)
  • Systematic Review
  • Open Access
8 Citations
4,936 Views
16 Pages

Objective. To investigate the influence of endogenous and exogenous neuroendocrine analogues on the range and motion of jaw movement, mandibular growth, and factors affecting condylar guidance in patients with temporomandibular joint disorders using...

(This article belongs to the Section Omics/Informatics)
  • Systematic Review
  • Open Access
8 Citations
2,832 Views
17 Pages

Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke

  • Chiara Siracusa,
  • Niccolò Vono,
  • Maria Benedetta Morano,
  • Jolanda Sabatino,
  • Isabella Leo,
  • Ceren Eyileten,
  • Eleonora Cianflone,
  • Marek Postula,
  • Daniele Torella and
  • Salvatore De Rosa

Despite the substantial improvement in diagnosis and treatment within the last decades, ischemic stroke still represents a challenge, responsible still for a high burden of morbidity and mortality. Among the unmet clinical needs are the difficulties...

(This article belongs to the Special Issue Diagnosis, Treatment and Prognosis of Cardiovascular Diseases 2.0)
  • Case Report
  • Open Access
2,271 Views
9 Pages

Open-Heart Cardio-Thoracic Biological Valve Replacement Following Complicated Transcatheter Aortic Valve Implantation

  • Aneta Klotzka,
  • Patrycja Woźniak,
  • Marcin Misterski,
  • Michał Rodzki,
  • Mateusz Puślecki,
  • Marek Jemielity,
  • Marek Grygier,
  • Aleksander Araszkiewicz,
  • Sylwia Iwańczyk and
  • Piotr Buczkowski

Transcatheter aortic valve implantation (TAVI) is currently becoming the method of choice in high-risk patients with severe aortic valve stenosis. Post-TAVI complications are more common owing to the increasing use of the method. The majority of TAVI...

(This article belongs to the Topic Cardiovascular Disease in 2023: Coronary Syndrome, Heart Failure and Structural Heart Disease)
  • Review
  • Open Access
22 Citations
9,618 Views
19 Pages

The dexamethasone suppression test (DST) assesses the functionality of the HPA axis and can be regarded as the first potential biomarker in psychiatry. In 1981, a group of researchers at the University of Michigan published a groundbreaking paper reg...

(This article belongs to the Special Issue Biomarkers in Psychiatric Disorders)
  • Article
  • Open Access
15 Citations
3,218 Views
13 Pages

Association of Sex Differences with Mortality and Organ Dysfunction in Patients with Sepsis and Septic Shock

  • Caspar Mewes,
  • Julius Runzheimer,
  • Carolin Böhnke,
  • Benedikt Büttner,
  • José Hinz,
  • Michael Quintel and
  • Ashham Mansur

Background: Despite recent advances in the clinical management and understanding of sepsis and septic shock, these complex clinical syndromes continue to have high mortality rates. The effect of sex on these diseases’ mortality, clinical presen...

(This article belongs to the Special Issue Sepsis Management and Critical Care)
  • Review
  • Open Access
8 Citations
17,890 Views
15 Pages

ARIA Care Pathways 2019: Next-Generation Allergic Rhinitis Care and Allergen Immunotherapy in Malaysia

  • Amir Hamzah Abdul Latiff,
  • Salina Husain,
  • Baharudin Abdullah,
  • Palaniappan Suppiah,
  • Vincent Tan,
  • Tang Ing Ping,
  • Kent Woo,
  • Yoke-Yeow Yap,
  • Claus Bachert and
  • Jean Bousquet
  • + 3 authors

An increase in the prevalence of allergic rhinitis (AR) worldwide presents a significant burden to the health care system. An initiative was started in Europe designated as Allergic Rhinitis and Its Impact on Asthma (ARIA) to develop internationally...

(This article belongs to the Section Mechanisms of Diseases)
  • Article
  • Open Access
14 Citations
5,457 Views
13 Pages

Oral Corticosteroid Abuse and Self-Prescription in Italy: A Perspective from Community Pharmacists and Sales Reports before and during the COVID-19 Era

  • Emanuele Nappi,
  • Enrico Keber,
  • Giovanni Paoletti,
  • Marta Casini,
  • Carolina Carosio,
  • Flora Romano,
  • Nicolina Floris,
  • Claudio Parmigiani,
  • Carlo Salvioni and
  • Corrado Giua
  • + 4 authors

(1) Background: Corticosteroids are commonly used for a variety of conditions, but their use might come with significant side effects. Self-medication practices increased during the COVID-19 pandemic, potentially favoring corticosteroid misuse. Studi...

  • Systematic Review
  • Open Access
9 Citations
13,028 Views
14 Pages

Causes of Polyserositis: A Systematic Review

  • Laura Elena Stoichitoiu,
  • Georgeta Daniela Ionescu,
  • Ingrid Neatu and
  • Cristian Baicus

At present, polyserositis (PS) remains a challenging entity, which resides both in the fact that there is confusion regarding the terminology, and that it is still understudied. We aimed to identify the etiologies of PS, reported in adult patients. M...

(This article belongs to the Section Personalized Therapy in Clinical Medicine)
  • Article
  • Open Access
31 Citations
5,474 Views
11 Pages

Accuracy of Conventional and Digital Impressions for Full-Arch Implant-Supported Prostheses: An In Vitro Study

  • Noemie Drancourt,
  • Chantal Auduc,
  • Aymeric Mouget,
  • Jean Mouminoux,
  • Pascal Auroy,
  • Jean-Luc Veyrune,
  • Nada El Osta and
  • Emmanuel Nicolas

Both conventional and digital impressions aim to record the spatial position of implants in the dental arches. However, there is still a lack of data to justify the use of intraoral scanning over conventional impressions for full-arch implant-support...

(This article belongs to the Special Issue Recent Advances in Dental Practice)
  • Article
  • Open Access
1 Citations
2,884 Views
10 Pages

Endoscopic Transpapillary Stenting for Malignant Hilar Biliary Stricture: Side-by-Side Placement versus Partial Stent-in-Stent Placement

  • Koji Takahashi,
  • Hiroshi Ohyama,
  • Yuichi Takiguchi,
  • Motoyasu Kan,
  • Mayu Ouchi,
  • Hiroki Nagashima,
  • Izumi Ohno and
  • Naoya Kato

Background/Aims: Endoscopic uncovered metal stent (UMS) placement has been widely performed for unresectable hilar malignant biliary stricture (UHMBS). Two stenting methods are used for the two bile duct branches: side-by-side placement (SBS) and par...

(This article belongs to the Special Issue Novel Challenges and Therapeutic Options for Digestive and Liver Diseases)
  • Feature Paper
  • Review
  • Open Access
28 Citations
5,860 Views
12 Pages

Precision Medicine in Fatty Liver Disease/Non-Alcoholic Fatty Liver Disease

  • Laura Valenzuela-Vallejo,
  • Despina Sanoudou and
  • Christos S. Mantzoros

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, and is related to fatal and non-fatal liver, metabolic, and cardiovascular complications. Its non-invasive diagnosis and effective treatment remain an unmet clinic...

(This article belongs to the Special Issue From Basic to Clinical Research: Toward Precision Medicine for Metabolic Diseases)
  • Case Report
  • Open Access
4 Citations
4,896 Views
12 Pages

Pharmacogenetic Analysis Enables Optimization of Pain Therapy: A Case Report of Ineffective Oxycodone Therapy

  • Florine M. Wiss,
  • Céline K. Stäuble,
  • Henriette E. Meyer zu Schwabedissen,
  • Samuel S. Allemann and
  • Markus L. Lampert

Patients suffering from chronic pain may respond differently to analgesic medications. For some, pain relief is insufficient, while others experience side effects. Although pharmacogenetic testing is rarely performed in the context of analgesics, res...

(This article belongs to the Section Pharmacogenetics)
  • Article
  • Open Access
7 Citations
2,339 Views
21 Pages

Blood Pressure Correlates with Serum Leptin and Body Mass Index in Overweight Male Saudi Students

  • Shalan Alaamri,
  • Abdulhalim S. Serafi,
  • Zahir Hussain,
  • Munira M. Alrooqi,
  • Mohammed A. Bafail and
  • Sumera Sohail

The precise association of serum leptin (Lep) with the body mass index (BMI) and blood pressure (BP) is not well known for understanding their involvement in health and disease. Hence, the present study was conducted to investigate the association of...

(This article belongs to the Topic Cardiovascular Disease in 2023: Coronary Syndrome, Heart Failure and Structural Heart Disease)

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J. Pers. Med. - ISSN 2075-4426