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Journal of Personalized Medicine, Volume 12, Issue 5

May 2022 - 197 articles

Cover Story: New systemic approaches for the treatment of hepatocellular carcinoma, as the fourth leading cause of cancer death in the world, are urgently required. Here, the two novel tyrosine kinase inhibitors Thio-Iva and Thio-Dam are shown to effectively attack cellular processes and features in HCC cells acquired during carcinogenesis that are referred to as hallmarks of cancer. Thus, Thio-Iva and Thio-Dam are promising novel compounds for the medical treatment of HCC. View this paper
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Articles (197)

  • Review
  • Open Access
17 Citations
5,248 Views
13 Pages

Paucigranulocytic Asthma: Potential Pathogenetic Mechanisms, Clinical Features and Therapeutic Management

  • Andriana I. Papaioannou,
  • Evangelia Fouka,
  • Polyxeni Ntontsi,
  • Grigoris Stratakos and
  • Spyridon Papiris

Asthma is a heterogeneous disease usually characterized by chronic airway inflammation, in which several phenotypes have been described, related to the age of onset, symptoms, inflammatory characteristics and treatment response. The identification of...

  • Feature Paper
  • Article
  • Open Access
7 Citations
3,000 Views
10 Pages

Gender-Specific Differences in the Intensive Care Treatment of COVID-19 Patients

  • Peter Jirak,
  • Moritz Mirna,
  • Vincent Van Almsick,
  • Zornitsa Shomanova,
  • Magdalena Mahringer,
  • Michael Lichtenauer,
  • Kristen Kopp,
  • Albert Topf,
  • Franz Sieg and
  • Johannes Kraus
  • + 7 authors

Background: Gender-specific differences in the outcome of COVID-19 patients requiring intensive care treatment have been reported. However, a potential association with ICU therapy remains elusive. Methods: A total of 224 consecutive patients (63 wom...

  • Article
  • Open Access
5 Citations
3,471 Views
15 Pages

Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer’s Disease: An Exploratory Analysis

  • Inés López-Cuenca,
  • Elena Salobrar-García,
  • Inés Gil-Salgado,
  • Lidia Sánchez-Puebla,
  • Lorena Elvira-Hurtado,
  • José A. Fernández-Albarral,
  • Federico Ramírez-Toraño,
  • Ana Barabash,
  • Jaisalmer de Frutos-Lucas and
  • Juan J. Salazar
  • + 3 authors

Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of...

  • Article
  • Open Access
8 Citations
3,058 Views
12 Pages

Cardiovascular Risk Assessment by SCORE2 Predicts Risk for Colorectal Neoplasia and Tumor-Related Mortality

  • Sarah Wernly,
  • Georg Semmler,
  • Andreas Völkerer,
  • Richard Rezar,
  • Leonora Datz,
  • Konrad Radzikowski,
  • Felix Stickel,
  • Elmar Aigner,
  • David Niederseer and
  • Bernhard Wernly
  • + 1 author

Objectives: The European Society of Cardiology endorsed SCORE2 to assess cardiovascular risk. The aim of this observational, retrospective study was to assess whether SCORE2 is associated with colorectal neoplasia in an asymptomatic screening populat...

  • Review
  • Open Access
36 Citations
7,505 Views
22 Pages

Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement

  • Eugenio De Corso,
  • Maria Beatrice Bilò,
  • Andrea Matucci,
  • Veronica Seccia,
  • Fulvio Braido,
  • Matteo Gelardi,
  • Enrico Heffler,
  • Manuela Latorre,
  • Luca Malvezzi and
  • Girolamo Pelaia
  • + 3 authors

Chronic rhinosinusitis (CRS) is a sino-nasal chronic inflammatory disease, occurring in 5–15% of the general population. CRS with nasal polyps (CRSwNP) is present in up to 30% of the CRS population. One-third of CRSwNP patients suffer from dise...

  • Review
  • Open Access
1 Citations
2,741 Views
10 Pages

The Impact of Hypoglycemic Therapy on the Prognosis for Acute Coronary Syndrome in Patients with Type 2 Diabetes

  • K. Yu. Nikolaev,
  • A. I. Shevela,
  • S. V. Mustafina,
  • O. D. Rymar,
  • A. K. Ovsyannikova,
  • E. M. Zelenskaya,
  • A. Y. Kovaleva and
  • G. I. Lifshits

The article discusses particular circumstances of acute coronary syndrome (ACS) in patients with type 2 diabetes (T2D). In addition, the available literature data and clinical guidelines reflecting the role of hypoglycemic therapy as a cardioprotecti...

  • Protocol
  • Open Access
13 Citations
4,308 Views
12 Pages

The registry project led by the Japanese Society for Clinical Transcranial Magnetic Stimulation (TMS) Research aims to establish a centralized database of epidemiological, clinical, and biological data on TMS therapy for refractory psychiatric disord...

  • Article
  • Open Access
6 Citations
3,257 Views
14 Pages

CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling

  • Shyng-Shiou F. Yuan,
  • Amos C. Hung,
  • Ching-Wei Hsu,
  • Ting-Hsun Lan,
  • Chang-Wei Su,
  • Tsung-Chen Chi,
  • Yu-Chiuan Chang,
  • Yuk-Kwan Chen and
  • Yen-Yun Wang

Oral cancer is one of the highest-incidence malignancies worldwide, with the occurrence of oral squamous cell carcinoma (OSCC) being the most frequently diagnosed form. A barrier for oral cancer management may arise from tumor cells that possess prop...

  • Article
  • Open Access
8 Citations
2,863 Views
15 Pages

This retrospective cohort study compares the virtual planned and postoperative jaw positions in patients undergoing orthognathic surgery. Surgery was virtually planned with the Digital Münster Model Surgery system (DMMS). Primary outcome: Spatia...

  • Systematic Review
  • Open Access
16 Citations
3,182 Views
8 Pages

The Impact of Concomitant Proton Pump Inhibitors on Immunotherapy Efficacy among Patients with Urothelial Carcinoma: A Meta-Analysis

  • Alessandro Rizzo,
  • Matteo Santoni,
  • Veronica Mollica,
  • Angela Dalia Ricci,
  • Concetta Calabrò,
  • Antonio Cusmai,
  • Gennaro Gadaleta-Caldarola,
  • Gennaro Palmiotti and
  • Francesco Massari

Background. Immune checkpoint inhibitors (ICIs) have recently represented a breakthrough in urothelial carcinoma (UC). Proton pump inhibitors (PPIs) are routinely used for extended time periods in UC patients, with these agents having potentially and...

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J. Pers. Med. - ISSN 2075-4426