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Diagnostics, Volume 15, Issue 9

May-1 2025 - 131 articles

Cover Story: Helicobacter pylori is a major risk factor for gastric cancer. The incidence and prevalence of the pathogen are increasing worldwide. We present an algorithm combining a feature pyramid network and a ResNet architecture for automatic and rapid H. pylori detection in digitized Warthin–Starry-stained gastric biopsies. The algorithm exhibited 0.923 average precision and 0.982 average recall. The conducted efficiency study demonstrated that algorithm utilization significantly decreased (p < 0.001) diagnostic turnaround times for all participants, observing an 88.13–91.76% time reduction. Implementation of the algorithm also improved diagnostic accuracy for the resident, technician, and biotechnologist, indicating that the tool remarkably supports less experienced personnel. View this paper
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Articles (131)

  • Article
  • Open Access
2,469 Views
15 Pages

Development of a Pulmonary Nodule Service and Clinical Pathway: A Pragmatic Approach Addressing an Unmet Need

  • Georgia Hardavella,
  • Ioannis Karampinis,
  • Nikolaos Anastasiou,
  • Konstantinos Stefanidis,
  • Kyriaki Tavernaraki,
  • Styliani Arapostathi,
  • Nektaria Sidiropoulou,
  • Petros Filippousis,
  • Alexandro Patirelis and
  • Eugenio Pompeo
  • + 2 authors

Background/Objectives: The surveillance of patients with incidental pulmonary nodules overloads existing respiratory and lung cancer clinics, as well as multidisciplinary team meetings. In our clinical setting, until 2018, we had numerous patients wi...

  • Review
  • Open Access
2,297 Views
16 Pages

Circulating Cell-Free DNA as an Epigenetic Biomarker for Early Diabetic Retinopathy: A Narrative Review

  • Boaz Li,
  • Megan M. Yim,
  • Yu Xuan Jin,
  • Brendan K. Tao,
  • Jim S. Xie,
  • Michael Balas,
  • Haaris Khan,
  • Wai-Ching Lam,
  • Peng Yan and
  • Eduardo V. Navajas

Diabetic retinopathy (DR), a complication of type 2 diabetes mellitus (T2DM), is typically asymptomatic in its early stages. Diagnosis typically relies on routine fundoscopy for the clinical detection of microvascular abnormalities. However, permanen...

  • Article
  • Open Access
2,022 Views
13 Pages

Background/Objectives: This study aims to determine the sensitivity, specificity, positive predictive value, and negative predictive value by comparing ultrasonography and panoramic radiography with the gold standard cone beam computed tomography in...

  • Interesting Images
  • Open Access
698 Views
3 Pages

18F-FDG PET/CT Findings in Glandular Tularemia

  • Freja Gustafsson,
  • Karl Keigo Rasmussen,
  • Kristina Thorsteinsson,
  • Anne-Mette Lebech and
  • Lasse Fjordside

A 47-year-old woman presented with fever, fatigue, night sweats and inguinal glandular swelling following a tick bite. Weeks of diagnostic uncertainty followed, and a lymph node biopsy was sent to be investigated for tularemia and pathology. An 18F-F...

  • Interesting Images
  • Open Access
1,141 Views
8 Pages

Radiological and Surgery Considerations and Alternatives in Total Temporomandibular Joint Replacement in Gorlin-Goltz Syndrome

  • Kamil Nelke,
  • Klaudiusz Łuczak,
  • Maciej Janeczek,
  • Agata Małyszek,
  • Piotr Kuropka and
  • Maciej Dobrzyński

Gorlin-Goltz syndrome (GGS) is also known as Nevoid basal cell carcinoma syndrome (NBCCS). In the most common manifestation, GGS is diagnosed based on multiple cysts in the jaw bones, namely OKCs (odontogenic keratocysts). Other features might includ...

  • Article
  • Open Access
2 Citations
2,198 Views
20 Pages

Background/Objectives: This study evaluates the diagnostic efficacy of the apparent diffusion coefficient (ADC) and T1-weighted contrast-enhanced (T1W + C) and T2-weighted (T2W) imaging modalities in differentiating vestibular schwannomas (VSs) and c...

  • Article
  • Open Access
1 Citations
2,634 Views
28 Pages

Automated Lightweight Model for Asthma Detection Using Respiratory and Cough Sound Signals

  • Shuting Xu,
  • Ravinesh C. Deo,
  • Oliver Faust,
  • Prabal D. Barua,
  • Jeffrey Soar and
  • Rajendra Acharya

Background and objective: Chronic respiratory diseases, such as asthma and COPD, pose significant challenges to human health and global healthcare systems. This pioneering study utilises AI analysis and modelling of cough and respiratory sound signal...

  • Article
  • Open Access
1,827 Views
20 Pages

EM-DeepSD: A Deep Neural Network Model Based on Cell-Free DNA End-Motif Signal Decomposition for Cancer Diagnosis

  • Zhi-Yang Zhao,
  • Chang-Ling Huang,
  • Tong-Min Wang,
  • Shi-Hao Zhou,
  • Lu Pei,
  • Wen-Hui Jia and
  • Wei-Hua Jia

Background and Objectives: The accurate discrimination between patients with and without cancer using their cell-free DNA (cfDNA) is crucial for early cancer diagnosis. The end-motifs of cfDNA serve as significant cancer biomarkers, offering compelli...

  • Article
  • Open Access
782 Views
11 Pages

Evaluation of Adipokine Status and Leptin Receptor Gene Polymorphism in Patients with Severe Asthma

  • Saule Maimysheva,
  • Lyudmila Karazhanova,
  • Andrey Orekhov,
  • Assel Chinybayeva and
  • Bolat Ashirov

Background: Severe and difficult-to-control asthma occurs in 3–10% of patients in developed countries. The aim of our study was to investigate the association of the prognostic role of leptin and adiponectin, as well as the leptin receptor gene...

  • Review
  • Open Access
5 Citations
3,874 Views
21 Pages

Diagnostic imaging is fundamental in dentistry for disease detection, treatment planning, and outcome assessment. Traditional radiographic methods, such as periapical and panoramic radiographs, along with cone beam computed tomography (CBCT), utilize...

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Diagnostics - ISSN 2075-4418