Exploring Fat Fraction and Vertebral Bone Quality Score in Lumbar Spine Magnetic Resonance Imaging: A Cross-Sectional Study on Associations and Clinical Implication
Abstract
1. Introduction
2. Materials and Methods
2.1. Patient Selection
2.2. Magnetic Resonance Imaging
2.3. Fat Fraction Measurement
2.4. Vertebral Bone Quality Score Measurement
2.5. Evaluation for Vertebral Lesions
- The typical imaging finding in all conventional MRI sequences.
- In cases of an acute vertebral fracture, findings diagnosed with CT or plain radiography, with accompanying trauma history.
- In cases other than fractures, the typical imaging appearance in MRI was taken at least 6 months before or after the evaluation.
2.6. Statistical Analysis
3. Results
3.1. Reproducibility
3.2. Correlation Between FFGRE and FFSE/VBQ Score
3.3. Correlation Between Age and FF/VBQ Score
3.4. Vertebral Lesions Analyses
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
BMAT | Bone marrow adipose tissue |
CSE-MRI | Chemical shift-encoded magnetic resonance imaging |
GRE | Gradient-echo |
FF | Fat fraction |
SE | Spin-echo |
VBQ | Vertebral bone quality |
TR | Repetition time |
TE | Echo time |
FOV | Field of view |
ROIs | regions of interest |
SI | Signal intensity |
CSF | Cerebrospinal fluid |
CI | confidence interval |
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Mean ± Standard Deviation | p | |
---|---|---|
FFGRE | 54.31 ± 11.04 | <0.001 |
FFSE | 74.13 ± 9.37 | |
VBQ score | 2.79 ± 0.58 |
FFGRE | FFSE | VBQ Score | ||||
---|---|---|---|---|---|---|
r | p | r | p | r | p | |
All (n = 344) | 0.583 | <0.001 | 0.477 | <0.001 | 0.468 | <0.001 |
Age < 50 (n = 79) | 0.538 | <0.001 | 0.488 | <0.001 | 0.372 | 0.001 |
Age ≥ 50 (n = 265) | 0.199 | 0.001 | 0.111 | 0.070 | 0.183 | 0.003 |
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Park, S.; Hwang, J.; Kwack, K.-S.; Lee, K.H.; Yun, J.S. Exploring Fat Fraction and Vertebral Bone Quality Score in Lumbar Spine Magnetic Resonance Imaging: A Cross-Sectional Study on Associations and Clinical Implication. Diagnostics 2025, 15, 503. https://doi.org/10.3390/diagnostics15040503
Park S, Hwang J, Kwack K-S, Lee KH, Yun JS. Exploring Fat Fraction and Vertebral Bone Quality Score in Lumbar Spine Magnetic Resonance Imaging: A Cross-Sectional Study on Associations and Clinical Implication. Diagnostics. 2025; 15(4):503. https://doi.org/10.3390/diagnostics15040503
Chicago/Turabian StylePark, Sunghoon, Jinwoo Hwang, Kyu-Sung Kwack, Kyu Hong Lee, and Jae Sung Yun. 2025. "Exploring Fat Fraction and Vertebral Bone Quality Score in Lumbar Spine Magnetic Resonance Imaging: A Cross-Sectional Study on Associations and Clinical Implication" Diagnostics 15, no. 4: 503. https://doi.org/10.3390/diagnostics15040503
APA StylePark, S., Hwang, J., Kwack, K.-S., Lee, K. H., & Yun, J. S. (2025). Exploring Fat Fraction and Vertebral Bone Quality Score in Lumbar Spine Magnetic Resonance Imaging: A Cross-Sectional Study on Associations and Clinical Implication. Diagnostics, 15(4), 503. https://doi.org/10.3390/diagnostics15040503