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Diagnostics, Volume 14, Issue 10

May-2 2024 - 93 articles

Cover Story: Successful adoption of digital pathology (DP) and AI depends upon the quality of digitised whole-slide images. The ability to automate image quality assessment will be important as more clinical laboratories adopt DP, and is likely to be an important consideration for the reliability of AI tools as these become available for diagnostic practice. In this feasibility study, we investigated the potential for PathProfiler, an automated image quality assessment tool, to be integrated into a prospective workflow in a real-world diagnostic pathology setting. We demonstrated the reliability of the tool in the identification of suboptimal WSI related particularly to biopsy specimens, flagging slides for remedial action such as re-scanning, and without significant impact on laboratory turnaround time. View this paper
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Articles (93)

  • Article
  • Open Access
6 Citations
5,462 Views
12 Pages

The Value of Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of Central Lung Cancer with Obstructive Atelectasis

  • Ehsan Safai Zadeh,
  • Katharina Paulina Huber,
  • Christian Görg,
  • Helmut Prosch and
  • Hajo Findeisen

Purpose: To assess the diagnostic performance of contrast-enhanced ultrasound (CEUS) alongside contrast-enhanced computed tomography (CECT) in evaluating central lung cancer (CLC). Materials and Methods: From 2006 to 2022, 54 patients with CLC and ob...

  • Article
  • Open Access
1 Citations
1,869 Views
16 Pages

Assessment of Calcaneal Spongy Bone Magnetic Resonance Characteristics in Women: A Comparison between Measures Obtained at 0.3 T, 1.5 T, and 3.0 T

  • Silvia Capuani,
  • Alessandra Maiuro,
  • Emiliano Giampà,
  • Marco Montuori,
  • Viviana Varrucciu,
  • Gisela E. Hagberg,
  • Vincenzo Vinicola and
  • Sergio Colonna

Background: There is a growing interest in bone tissue MRI and an even greater interest in using low-cost MR scanners. However, the characteristics of bone MRI remain to be fully defined, especially at low field strength. This study aimed to characte...

  • Article
  • Open Access
13 Citations
3,571 Views
15 Pages

A Multichannel CT and Radiomics-Guided CNN-ViT (RadCT-CNNViT) Ensemble Network for Diagnosis of Pulmonary Sarcoidosis

  • Jianwei Qiu,
  • Jhimli Mitra,
  • Soumya Ghose,
  • Camille Dumas,
  • Jun Yang,
  • Brion Sarachan and
  • Marc A. Judson

Pulmonary sarcoidosis is a multisystem granulomatous interstitial lung disease (ILD) with a variable presentation and prognosis. The early accurate detection of pulmonary sarcoidosis may prevent progression to pulmonary fibrosis, a serious and potent...

  • Article
  • Open Access
6 Citations
2,107 Views
12 Pages

The Role of T2 Mapping in Cardiac Amyloidosis

  • Giulia Grazzini,
  • Silvia Pradella,
  • Rossella Bani,
  • Chiara Fornaciari,
  • Francesco Cappelli,
  • Federico Perfetto,
  • Diletta Cozzi,
  • Simona Giovannelli,
  • Giacomo Sica and
  • Vittorio Miele

Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy divided into two types: light-chain (LA) and transthyretin (ATTR) CA. Cardiac magnetic resonance (CMR) has emerged as an important diagnostic tool in CA. While late gadolinium enhancement (LG...

  • Article
  • Open Access
5 Citations
2,780 Views
11 Pages

Identifying Autism Gaze Patterns in Five-Second Data Records

  • Pedro Lencastre,
  • Maryam Lotfigolian and
  • Pedro G. Lind

One of the most challenging problems when diagnosing autism spectrum disorder (ASD) is the need for long sets of data. Collecting data during such long periods is challenging, particularly when dealing with children. This challenge motivates the inve...

  • Article
  • Open Access
3 Citations
2,119 Views
12 Pages

Generation and Validation of Normative, Age-Specific Reference Curves for Bone Strain Index in Women

  • Luca Rinaudo,
  • Sofia Cuttone,
  • Carmelo Messina,
  • Veronica Magni,
  • Davide Capra,
  • Luca Maria Sconfienza,
  • Francesco Sardanelli and
  • Fabio Massimo Ulivieri

Bone Strain Index (BSI), based on dual-energy X-ray absorptiometry (DXA), is a densitometric index of bone strength of the femur and lumbar spine. Higher BSI values indicate a higher strain applied to bone, predisposing to higher fracture risk. This...

  • Review
  • Open Access
16 Citations
6,042 Views
20 Pages

A Comprehensive Review on Circulating cfRNA in Plasma: Implications for Disease Diagnosis and Beyond

  • Pengqiang Zhong,
  • Lu Bai,
  • Mengzhi Hong,
  • Juan Ouyang,
  • Ruizhi Wang,
  • Xiaoli Zhang and
  • Peisong Chen

Circulating cfRNA in plasma has emerged as a fascinating area of research with potential applications in disease diagnosis, monitoring, and personalized medicine. Circulating RNA sequencing technology allows for the non-invasive collection of importa...

  • Article
  • Open Access
10 Citations
5,508 Views
17 Pages

Epithelial Cell Adhesion Molecule (EpCAM) Expression in Human Tumors: A Comparison with Pan-Cytokeratin and TROP2 in 14,832 Tumors

  • Anne Menz,
  • Nora Lony,
  • Maximilian Lennartz,
  • Sebastian Dwertmann Rico,
  • Ria Schlichter,
  • Simon Kind,
  • Viktor Reiswich,
  • Florian Viehweger,
  • David Dum and
  • Andreas M. Luebke
  • + 16 authors

EpCAM is expressed in many epithelial tumors and is used for the distinction of malignant mesotheliomas from adenocarcinomas and as a surrogate pan-epithelial marker. A tissue microarray containing 14,832 samples from 120 different tumor categories w...

  • Review
  • Open Access
7 Citations
5,118 Views
21 Pages

PET/CT Imaging of Infectious Diseases: Overview of Novel Radiopharmaceuticals

  • Ferdinando F. Calabria,
  • Giuliana Guadagnino,
  • Andrea Cimini and
  • Mario Leporace

Infectious diseases represent one of the most common causes of hospital admission worldwide. The diagnostic work-up requires a complex clinical approach, including laboratory data, CT and MRI, other imaging tools, and microbiologic cultures. PET/CT w...

  • Article
  • Open Access
1 Citations
2,022 Views
16 Pages

The Role of QRS Complex and ST-Segment in Major Adverse Cardiovascular Events Prediction in Patients with ST Elevated Myocardial Infarction: A 6-Year Follow-Up Study

  • Srđan Maletin,
  • Milovan Petrović,
  • Anastazija Stojšić-Milosavljević,
  • Tatjana Miljković,
  • Aleksandra Milovančev,
  • Ivan Petrović,
  • Isidora Milosavljević,
  • Ana Balenović and
  • Milenko Čanković

Background: as a relatively high number of ST-segment elevation myocardial infarction (STEMI) patients develop major adverse cardiovascular events (MACE) following percutaneous coronary intervention (PCI), our aim was to determine the significance, a...

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Diagnostics - ISSN 2075-4418