Next Article in Journal
Volumetric MRI Analysis of Brain Structures in Patients with History of First and Repeated Suicide Attempts: A Cross Sectional Study
Previous Article in Journal
Use of Contrast-Enhanced Ultrasound with Sonazoid for Evaluating the Radiotherapy Efficacy for Hepatocellular Carcinoma
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 11
Issue 3
10.3390/diagnostics11030487
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations

by
Eunjue Yi
1,†,
Naoki Sunaguchi
2,†,
Jeong Hyeon Lee
3,
Chul-Yong Kim
4,
Sungho Lee
1,
Sanghoon Jheon
5,
Masami Ando
6 and
Yangki Seok
7,*
1
Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, Seoul 02841, Korea
2
Department of Radiological and Medical Laboratory Sciences, Graduate School of Medicine, Nagoya University, Nagoya 464-8601, Japan
3
Department of Pathology, Korea University Anam Hospital, Seoul 02841, Korea
4
Department of Radiation Oncology, Korea University Anam Hospital, Seoul 02841, Korea
5
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea
6
Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba 300-3256, Japan
7
Department of Thoracic and Cardiovascular Surgery, Soonchunhyang University Gumi Hospital, Gumi 39371, Korea
*
Author to whom correspondence should be addressed.
†
Both authors contributed equally to this work.
Diagnostics 2021, 11(3), 487; https://doi.org/10.3390/diagnostics11030487
Submission received: 28 January 2021 / Revised: 2 March 2021 / Accepted: 7 March 2021 / Published: 10 March 2021
(This article belongs to the Section Medical Imaging and Theranostics)
Browse Figures
Review Reports Versions Notes

Abstract

The aim of this study was to evaluate the clinical implication of synchrotron radiation imaging techniques for human lung adenocarcinoma in comparison with pathologic examination. A refraction-based tomographic imaging technique called the X-ray dark-field imaging (XDFI) method was used to obtain computed tomographic images of human lung adenocarcinoma at the beam line at Photon Factory BL 14B at the High Energy Accelerator Research Organization (KEK) in Tsukuba, Japan. Images of normal lung tissue were also obtained using the same methods and reconstructed as 3D images. Both reconstructed images were compared with pathologic examinations from histologic slides which were made with identical samples. Pulmonary alveolar structure including terminal bronchioles, alveolar sacs, and vasculatures could be identified in synchrotron radiation images of normal lung. Hyperplasia of interstitial tissue and dysplasia of alveolar structures were noticed in images of lung adenocarcinoma. Both synchrotron radiation images were considerably correlated with images from histologic slides. Lepidic patterns of cancer tissue were distinguished from the invasive area in synchrotron radiation images of lung adenocarcinoma. Refraction-contrast tomographic techniques using synchrotron radiation could provide high-resolution images of lung adenocarcinoma which are compatible with those from pathologic examinations.
Keywords: synchrotron X-ray; lung adenocarcinoma; histology synchrotron X-ray; lung adenocarcinoma; histology

Share and Cite

MDPI and ACS Style

Yi, E.; Sunaguchi, N.; Lee, J.H.; Kim, C.-Y.; Lee, S.; Jheon, S.; Ando, M.; Seok, Y. Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations. Diagnostics 2021, 11, 487. https://doi.org/10.3390/diagnostics11030487

AMA Style

Yi E, Sunaguchi N, Lee JH, Kim C-Y, Lee S, Jheon S, Ando M, Seok Y. Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations. Diagnostics. 2021; 11(3):487. https://doi.org/10.3390/diagnostics11030487

Chicago/Turabian Style

Yi, Eunjue, Naoki Sunaguchi, Jeong Hyeon Lee, Chul-Yong Kim, Sungho Lee, Sanghoon Jheon, Masami Ando, and Yangki Seok. 2021. "Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations" Diagnostics 11, no. 3: 487. https://doi.org/10.3390/diagnostics11030487

APA Style

Yi, E., Sunaguchi, N., Lee, J. H., Kim, C.-Y., Lee, S., Jheon, S., Ando, M., & Seok, Y. (2021). Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations. Diagnostics, 11(3), 487. https://doi.org/10.3390/diagnostics11030487

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop