Next Article in Journal
Testing New Concepts for Crop Cultivation in Space: Effects of Rooting Volume and Nitrogen Availability
Previous Article in Journal
Efficient Arrangement of the Replication Fork Trap for In Vitro Propagation of Monomeric Circular DNA in the Chromosome-Replication Cycle Reaction
Article Menu

Export Article

Open AccessArticle

Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code through Origin of Life

1
Roswell Park Cancer Institute, Department of Molecular & Cellular Biology, Buffalo, NY 14263, USA
2
Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 21, Sofia 1113, Bulgaria
*
Author to whom correspondence should be addressed.
Received: 8 August 2018 / Revised: 30 September 2018 / Accepted: 30 September 2018 / Published: 2 October 2018
(This article belongs to the Section Hypotheses in the Life Sciences)
Full-Text   |   PDF [2117 KB, uploaded 11 October 2018]   |  

Abstract

One of the most intriguing questions in biological science is how life originated on Earth. A large number of hypotheses have been proposed to explain it, each putting an emphasis on different events leading to functional translation and self-sustained system. Here, we propose a set of interactions that could have taken place in the prebiotic environment. According to our hypothesis, hybridization-induced proximity of short aminoacylated RNAs led to the synthesis of peptides of random sequence. We postulate that among these emerged a type of peptide(s) capable of stimulating the interaction between specific RNAs and specific amino acids, which we call “bridge peptide” (BP). We conclude that translation should have emerged at the same time when the standard genetic code begun to evolve due to the stabilizing effect on RNA-peptide complexes with the help of BPs. Ribosomes, ribozymes, and the enzyme-directed RNA replication could co-evolve within the same period, as logical outcome of RNA-peptide world without the need of RNA only self-sustained step. View Full-Text
Keywords: origin of life; hybridization-dependent peptide; origin of genetic code; translation; ribozymes; RNA world; RNA-peptide world origin of life; hybridization-dependent peptide; origin of genetic code; translation; ribozymes; RNA world; RNA-peptide world
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kunnev, D.; Gospodinov, A. Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code through Origin of Life. Life 2018, 8, 44.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Life EISSN 2075-1729 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top