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Volume 15
Issue 8
10.3390/life15081208
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Brief Report

Transarterial Embolization for Chronic Postsurgical or Posttraumatic Pain of Musculoskeletal Origin: Clinical Outcomes and Imaging Correlates

by
Zi-Rui Huang
1,†,
Pei-Yi Chen
2,†,
Neng-Yu Chiu
3,†,
Sheng-Chieh Lin
4,5,
Bow Wang
6,7,
Jui-An Lin
8,9,10,11,12,*,‡ and
Keng-Wei Liang
3,13,*,‡
1
Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital, Taichung 402306, Taiwan
2
Department of Physical Medicine and Rehabilitation, Kinmen Hospital, Ministry of Health and Welfare, Kinmen 89142, Taiwan
3
Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung 402306, Taiwan
4
Department of Orthopedics, Chung Shan Medical University Hospital, Taichung 402306, Taiwan
5
Institute of Medicine, Chung Shan Medical University, Taichung 402306, Taiwan
6
Department of Medical Imaging, National Cheng Kung University Hospital, Tainan 701401, Taiwan
7
College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan
8
Department of Anesthesiology, Chung Shan Medical University Hospital, Taichung 402306, Taiwan
9
Department of Anesthesiology, School of Medicine, Chung Shan Medical University, Taichung 402306, Taiwan
10
Center for Regional Anesthesia and Pain Management, Chung Shan Medical University, Taichung 402306, Taiwan
11
Department of Anesthesiology, School of Medicine, National Defense Medical Center, Taipei 114201, Taiwan
12
Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
13
School of Medicine, Chung Shan Medical University, Taichung 402306, Taiwan
 
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Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
These authors also contributed equally to this work.
Life 2025, 15(8), 1208; https://doi.org/10.3390/life15081208
Submission received: 24 June 2025 / Revised: 19 July 2025 / Accepted: 23 July 2025 / Published: 29 July 2025
(This article belongs to the Special Issue A Paradigm Shift in Airway and Pain Management—2nd Edition)
Versions Notes

Abstract

Chronic postsurgical or posttraumatic pain (CPSP) is a persistent pain condition lasting beyond three months after tissue injury, often associated with neuropathic features and pathological angiogenesis. This study investigated the feasibility, safety, and therapeutic potential of transarterial embolization (TAE) in patients with CPSP arising from prior musculoskeletal surgeries or interventions. Six patients with refractory pain and imaging evidence of abnormal neovascularization were retrospectively reviewed. TAE was performed using imipenem/cilastatin particles to selectively target pathological vasculature. Eleven procedures were conducted, achieving 100% technical and clinical success. Mean Numeric Rating Scale scores improved significantly from 7.8 at baseline to 1.3 at final follow-up (p < 0.001). No major adverse events occurred, and follow-up imaging demonstrated resolution of inflammation in selected cases. These results support the role of TAE as a minimally invasive treatment option for intervention-related CPSP involving the musculoskeletal system, and further prospective studies are warranted.

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MDPI and ACS Style

Huang, Z.-R.; Chen, P.-Y.; Chiu, N.-Y.; Lin, S.-C.; Wang, B.; Lin, J.-A.; Liang, K.-W. Transarterial Embolization for Chronic Postsurgical or Posttraumatic Pain of Musculoskeletal Origin: Clinical Outcomes and Imaging Correlates. Life 2025, 15, 1208. https://doi.org/10.3390/life15081208

AMA Style

Huang Z-R, Chen P-Y, Chiu N-Y, Lin S-C, Wang B, Lin J-A, Liang K-W. Transarterial Embolization for Chronic Postsurgical or Posttraumatic Pain of Musculoskeletal Origin: Clinical Outcomes and Imaging Correlates. Life. 2025; 15(8):1208. https://doi.org/10.3390/life15081208

Chicago/Turabian Style

Huang, Zi-Rui, Pei-Yi Chen, Neng-Yu Chiu, Sheng-Chieh Lin, Bow Wang, Jui-An Lin, and Keng-Wei Liang. 2025. "Transarterial Embolization for Chronic Postsurgical or Posttraumatic Pain of Musculoskeletal Origin: Clinical Outcomes and Imaging Correlates" Life 15, no. 8: 1208. https://doi.org/10.3390/life15081208

APA Style

Huang, Z.-R., Chen, P.-Y., Chiu, N.-Y., Lin, S.-C., Wang, B., Lin, J.-A., & Liang, K.-W. (2025). Transarterial Embolization for Chronic Postsurgical or Posttraumatic Pain of Musculoskeletal Origin: Clinical Outcomes and Imaging Correlates. Life, 15(8), 1208. https://doi.org/10.3390/life15081208

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