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Life, Volume 12, Issue 5

May 2022 - 166 articles

Cover Story: The mouth represents an important route of entry for SARS-CoV-2. Oral epithelium cells, taste buds, and salivary glands express cellular entry factors for the virus, such as ACE2, TMPRSS2, and Furin. This leads to symptoms such as taste alteration, salivary dysfunction, and mucosal ulcers. We reviewed the current prevalence and socio-demographics data of taste disturbances in COVID-19 patients and collected the hypothesized pathogenetic mechanisms. Gustatory dysfunction is frequently found during COVID-19, but prevalence varies by country, age, and sex, and its duration is related to the disease severity. The pathogenesis is linked to the several possible ways of viral action. Further studies are needed to confirm the pathogenetic hypothesis of this COVID-19 manifestation and to better delineate the natural history of this infection. View this paper
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Articles (166)

  • Article
  • Open Access
9 Citations
2,769 Views
13 Pages

Histomorphometry of Ossification in Functionalised Ceramics with Tripeptide Arg-Gly-Asp (RGD): An In Vivo Study

  • Filippo Migliorini,
  • Hanno Schenker,
  • Nicola Maffulli,
  • Frank Hildebrand and
  • Jörg Eschweiler

20 May 2022

The present study investigated the osseointegration promoted by functionalised ceramics with peptide Arg-Gly-Asp (RGD) in a rabbit model in vivo. Histomorphometry of the RGD functionalised ceramic implants was conducted by a trained pathologist to qu...

  • Review
  • Open Access
15 Citations
7,754 Views
14 Pages

Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases

  • Danial Khayatan,
  • Seyed Mehrad Razavi,
  • Zahra Najafi Arab,
  • Maryam Khanahmadi,
  • Saeideh Momtaz,
  • Alexandra E. Butler,
  • Fabrizio Montecucco,
  • Yuliya V. Markina,
  • Amir Hossein Abdolghaffari and
  • Amirhossein Sahebkar

20 May 2022

Adverse cardiovascular disease (CVD) outcomes, such as sudden cardiac death, acute myocardial infarction, and stroke, are often catastrophic. Statins are frequently used to attenuate the risk of CVD-associated morbidity and mortality through their im...

  • Article
  • Open Access
10 Citations
5,288 Views
16 Pages

20 May 2022

DNA carries more than the list of biochemical ingredients that drive the basic functions of living systems. The sequence of base pairs includes a multitude of structural and energetic signals, which determine the degree to which the long, threadlike...

  • Article
  • Open Access
4 Citations
4,358 Views
10 Pages

The Effectiveness of Shoulder Mobility and Strength Programs in Competitive Water-Polo Players

  • Isaac López-Laval,
  • Sebastian Sitko,
  • Jaime Cantonero,
  • Francisco Corbi and
  • Rafel Cirer-Sastre

20 May 2022

Background: Water-polo is the water sport with the highest incidence of injuries, with shoulder pain being the most common one. The understanding of risk factors and guidance on preventive measures is essential in this sport discipline. The aim of th...

  • Review
  • Open Access
8 Citations
3,367 Views
17 Pages

20 May 2022

Stroma–cancer cell crosstalk involves a complex signaling network that contributes to tumor progression, including carcinogenesis, angiogenesis, migration, invasion, and therapy resistance in cancers. Exosomes, as extracellular membranous nanov...

  • Article
  • Open Access
6 Citations
3,165 Views
15 Pages

Human Amniotic Mesenchymal Stem Cells and Fibroblasts Accelerate Wound Repair of Cystic Fibrosis Epithelium

  • Elisa Beccia,
  • Valeria Daniello,
  • Onofrio Laselva,
  • Giorgia Leccese,
  • Michele Mangiacotti,
  • Sante Di Gioia,
  • Gianfranco La Bella,
  • Lorenzo Guerra,
  • Maria Matteo and
  • Antonella Angiolillo
  • + 1 author

19 May 2022

Cystic fibrosis (CF) airways are affected by a deranged repair of the damaged epithelium resulting in altered regeneration and differentiation. Previously, we showed that human amniotic mesenchymal stem cells (hAMSCs) corrected base defects of CF air...

  • Communication
  • Open Access
8 Citations
5,393 Views
20 Pages

Prevention and Treatment of Life-Threatening COVID-19 May Be Possible with Oxygen Treatment

  • Jukka Ylikoski,
  • Jarmo Lehtimäki,
  • Rauno Pääkkönen and
  • Antti Mäkitie

19 May 2022

Most SARS CoV-2 infections probably occur unnoticed or cause only cause a mild common cold that does not require medical intervention. A significant proportion of more severe cases is characterized by early neurological symptoms such as headache, fat...

  • Communication
  • Open Access
4 Citations
2,545 Views
9 Pages

Increased Levels of Beta-Endorphin and Noradrenaline after a Brief High-Impact Multidimensional Rehabilitation Program in Multiple Sclerosis

  • Alessia d’Arma,
  • Marina Saresella,
  • Valentina Rossi,
  • Ivana Marventano,
  • Federica Piancone,
  • Francesca La Rosa,
  • Mario Clerici and
  • Laura Mendozzi

19 May 2022

Finding new solutions for the management of multiple sclerosis (MS) is crucial: further research is needed to study the effect of non-pharmacological interventions on the symptoms and the course of the disease, especially on lifestyle. Benefits from...

  • Article
  • Open Access
7 Citations
4,616 Views
13 Pages

19 May 2022

Nerve injury causes hyperexcitability of the dorsal root ganglion (DRG) and spinal dorsal horn (DH) neurons, which results in neuropathic pain. We have previously demonstrated that partial dorsal rhizotomy (PDR) produced less severe pain-like behavio...

  • Article
  • Open Access
5 Citations
3,260 Views
17 Pages

SIRT1: Genetic Variants and Serum Levels in Age-Related Macular Degeneration

  • Kriste Kaikaryte,
  • Greta Gedvilaite,
  • Alvita Vilkeviciute,
  • Loresa Kriauciuniene,
  • Ruta Mockute,
  • Dzastina Cebatoriene,
  • Reda Zemaitiene,
  • Vilma Jurate Balciuniene and
  • Rasa Liutkeviciene

19 May 2022

Background: The aim of this paper was to determine the frequency of SIRT1 rs3818292, rs3758391, rs7895833 single nucleotide polymorphism genotypes and SIRT1 serum levels associated with age-related macular degeneration (AMD) in the Lithuanian populat...

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Life - ISSN 2075-1729