Life, Volume 11, Issue 3 (March 2021) – 89 articles
Cover Story (view full-size image): Autophagy, which is essential for the homeostasis and cell viability of ocular tissues, can be altered in ocular pathologies. In glaucoma, autophagy is activated at the onset of the disease in response to elevated intraocular pressure, but if it becomes chronic, autophagy decreases and promotes the pathogenesis and progression of glaucoma. Alterations in autophagy in lens fibres decrease their transparency and lead to the development of cataracts. Autophagy is responsible for the defence of the RPE against damage, but under conditions of excessive metabolic stress, autophagic activity is altered and leads to damage in diabetic retinopathy. In AMD, autophagy in RPE cells is decreased, showing that it is closely related to AMD pathogenesis. Therefore, regulation and modulation of autophagy could be a potential therapy for the treatment of ocular pathologies. View this paper
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