Special Issue "Synthetic Genetic Elements, Devices, and Systems"
Deadline for manuscript submissions: 30 September 2021.
Interests: biological containment; synthetic biology; development of novel genetic parts; unnatural amino acids; heterologous protein production
Interests: genetic circuit; modular design; promoter design; insulator
Since the beginning of life on Earth, over the course of 3–4 billion years, nature has created vast numbers of genetic elements. These freshly created elements faced natural selection. Winners survived and losers disappeared. Nature selected only the genetically stable elements that contributed to the maintenance of life. From a contrary perspective, natural selection restricted the diversity of genetic elements. In the last 20 years, i.e., 2 × 10−8 billion years, synthetic biologists have tried to create novel genetic elements that “nature has not invented or cannot invent”. The objective of this research is to go beyond the restriction of natural selection and obtain novel genetic elements that are “useful for human use”. From the limited modification of characteristics of natural elements to originally designed elements, various synthetic genetic elements have been reported. “Genetic devices”, such as logic gates and memory elements, and higher order “genetic systems”, such as metabolite factories and biological containment systems, can be constructed using these synthetic genetic elements in combination with other genetic elements. Through this approach, the incorporation of synthetic genetic elements is dramatically expanding biological functions.
This Special Issue "Synthetic Genetic Elements, Devices, and Systems" will explore the current state-of-the-art in this growing field. We hereby invite articles (full articles, short communications, and reviews) covering a broad range of topics.
Topics for this Special Issue include, but are not limited to:
a) Synthetic genetic elements in prokaryotes and eukaryotes (promoters, transcription factors, RBS, degradation tags, transcriptional terminators, sensors, indicators, ribozymes and riboswitches, enzymes such as recombinases and proteases as regulatory elements, etc.).
b) Synthetic genetic circuits as devices and systems (either involving or not involving synthetic genetic elements, but with the purpose of eliciting designed behavior).
c) Methods to develop synthetic genetic elements, devices, and systems.
d) Applications for laboratory and industrial use.
e) History and future perspectives.
Dr. Yusuke Kato
Prof. Dr. Chunbo Lou
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- synthetic biology
- synthetic genetic elements/parts
- artificial gene synthesis
- directed evolution
- metabolic engineering/cell factory
- genetic code expansion
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Title: Protein-based systems for translational regulation of synthetic mRNAs in mammalian cells Author: Hideyuki Nakanishi (Tokyo Medical and Dental University)
2. Title: CRISPR-based genetic switches: mechanism and application
Author: Pei Du, Chunbo Lou, Xuejin Zhao, Weijia Wei, Xiangyu Ji and Qihui Wang; (Chinese Academy of Sciences)
3. Title: Evolutionary engineering of yeast transcriptional controllers
Author: Masahiro Tominaga, Akihiko Kondo and Jun Ishii; (Kobe University)
4. Title: Confirming
Author: Yusuke Kato; (National Agriculture and Food Research Organization (NARO))