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Antibodies, Volume 6, Issue 2

June 2017 - 3 articles

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Article

7 Citations

6,796 Views

16 Pages

Dimerized Domain V of Beta2-Glycoprotein I Is Sufficient to Upregulate Procoagulant Activity in PMA-Treated U937 Monocytes and Require Intact Residues in Two Phospholipid-Binding Loops

Alexey Kolyada,
David A. Barrios and
Natalia Beglova

Antibodies2017, 6(2), 8;https://doi.org/10.3390/antib6020008

2 June 2017

Upregulation of the procoagulant activity of monocytes by antibodies to beta2-glycoprotein I (β2GPI) is one of the mechanisms contributing to thrombosis in antiphospholipid syndrome. Current knowledge about receptors responsible for the upregulation...

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Article

9 Citations

9,744 Views

16 Pages

Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function

Eric Escobar-Cabrera,
Paula Lario,
Jason Baardsnes,
Joseph Schrag,
Yves Durocher and
Surjit Dixit

Antibodies2017, 6(2), 7;https://doi.org/10.3390/antib6020007

16 May 2017

Asymmetric bispecific antibodies are a rapidly expanding therapeutic antibody class, designed to recognize two different target epitopes concurrently to achieve novel functions not available with normal antibodies. Many therapeutic designs require an...

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Article

8 Citations

8,462 Views

16 Pages

Collagen Autoantibodies and Their Relationship to CCP Antibodies and Rheumatoid Factor in the Progression of Early Rheumatoid Arthritis

Senga F. Whittingham,
Alex Stockman and
Merrill J. Rowley

Antibodies2017, 6(2), 6;https://doi.org/10.3390/antib6020006

5 April 2017

Serum autoantibodies to cyclic citrullinated peptides (anti-CCP) and rheumatoid factor (RF) are important markers for diagnosis and prognosis of rheumatoid arthritis (RA), but their autoantigens are not cartilage-specific. Autoantibodies to joint-spe...

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