Genes, Volume 8, Issue 6 (June 2017) – 23 articles
Cover Story (view full-size image): MYC is a key regulator of cell type progression, apoptosis and cellular transformation; however, it is also an oncogene whose unchecked overexpression leads to genomic instability, one of the hallmarks of cancer. Genotoxic chemotherapeutic drugs kill cancer cells by inducing double strand breaks and cell death. Paradoxically, oncogenic MYC induces chemoresistance by sensitizing the cellular DNA-repair machinery, implying an antagonistic role of MYC in genomic instability. View the paper
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