MYC Networks

Dear Colleagues,

Regardless of its comprehensive and in-depth study over more than three decades, the c-MYC protein is still biologically an enigmatic topic of research. The protein plays a central role in various cellular functions, including cell-cycle progression, de-differentiation, genomic instability, apoptosis, and metabolism, but also in recently-emerged research areas, such as pluripotency in iPS and cancer stem cells, epigenetic gene regulation, chromatin remodeling, RNA splicing, and immune response. As a bona fide oncogenic transcription factor, c-MYC has also been recognized as a fascinating anticancer therapeutic target. However, the precise mechanism(s) through which c-MYC properly exerts its divergent cellular functions remain obscure. It is significant to better understand direct and indirect regulatory/effector molecules of c-MYC pathways and protein components in c-MYC-containing high-molecular-weight complexes: It may provide conceptually a new anticancer drug design target in cancers addicted to c-MYC.

In this Special Issue, we would like to invite submission of original research or review articles on any topic related to the “c-MYC Networks”, through which we hope to explore new horizons of the thrilling functions of c-MYC in normal tissue development and tumorigenesis.

We look forward to receiving your contributions.

Dr. Daitoku Sakamuro
Guest Editor

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