Special Issue "Therapeutic Alternative Splicing: Mechanisms and Applications"
Deadline for manuscript submissions: closed (31 October 2016).
Induced exon skipping is currently the only treatment strategy to have restored dystrophin expression and altered the natural history of Duchenne muscular dystrophy. Antisense oligomers can also be used to alter splice site selection to enhance exon inclusion, promote alternative splicing or suppress aberrant pre-mRNA processing. While splice modifying therapeutics are being developed for several human diseases, the techniques are also applicable to induction of animal models and to the study of gene expression. Not surprisingly, given the central role of splicing regulation in gene expression, aberrant splicing has been recognized as a major cause of human disease, and presents opportunities for intervention. In a single issue of Genes, we will summarize the current state of antisense oligomer mediated exon selection. We welcome reviews and original articles in the area of induced alternative splicing, including therapeutic applications, mechanistic studies, and oligomer design, delivery and evaluation.
Prof. Susan Fletcher
Prof. Steve Wilto
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Antisense oligomer
- pre-mRNA splicing
- Duchenne muscular dystrophy
- exon selection
- oligonucleotide therapeutics