Special Issue "Genetics and Functional Genomics of Diabetes Mellitus"
Deadline for manuscript submissions: closed (31 January 2017).
Dr. Rajkumar Dorajoo
Genome Institute of Singapore, A*STAR, Singapore
Diabetes mellitus is a heterogeneous clinical entity, characterized by high blood sugar levels. Diabetes is a major public health problem that is approaching epidemic proportions globally. Since 1980, age-standardized diabetes prevalence in adults has increased. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes, affecting around 400 million people worldwide 1.
Once considered “Diabetes Mellitus: A Geneticist’s Nightmare” 2, technologies have greatly enabled the resolution of disease-relevant genomic regions, and ultimately defined disease causing variants describing specific, i.e., monogenic disease variants.
The combination of genomic studies with functional assays is now providing the rationale for dissecting diabetes mellitus into various subtypes. Still lacking is a full translation of already existing knowledge into clinical practice. There is an unmet need in view of the substantial health burden to translate genetic and functional information into stratified treatment and monitoring approaches. However, the identification of informative mutations has provided proof of principle of this kind of approach 3.
Herein, we will summarize current knowledge on genetics and functional genomics of diabetes mellitus, covering common and rare variants, from autoimmunity to insulin resistance and impaired glucose-induced insulin secretion disease phenotypes.
- NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants. Lancet 2016, doi:10.1016/S0140-6736(16)00618-8.
- Neel, J. Diabetes mellitus: A geneticist’s nightmare. In The Genetics of Diabetes Mellitus; Creutzfeldt, W., Kobberling, J., Neel, J.V., Eds.; Springer-Verlag: Berlin, Germany, 1976; pp. 1–11.
- Pearson, E.R. Personalized medicine in diabetes: The role of “omics” and biomarkers. Diabetic Med. 2016, in press.
Prof. Dr. Bernhard O. Boehm
Dr. Rajkumar Dorajoo
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