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Genes, Volume 16, Issue 6

June 2025 - 110 articles

Cover Story: Obesity is a major global health burden and a leading contributor to heart failure, yet the molecular mechanisms connecting them remain poorly defined. MicroRNAs (miRNAs)—small non-coding RNAs—regulate key pathways implicated in heart failure pathogenesis, including inflammation, cardiac remodeling, angiogenesis, mitochondrial dysfunction, and lipotoxicity. This review integrates evidence from preclinical models and in vitro studies to highlight miRNAs altered in obesity and heart failure, including those shared between both conditions. By elucidating these conserved molecular signatures, this work may inform the development of miRNA-based biomarkers and targeted therapies for obesity-associated heart failure. View this paper
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Articles (110)

  • Article
  • Open Access
779 Views
14 Pages

19 June 2025

Background: Cashmere is one of the important economic products of goats, and the KRTAP gene family, as an important family of regulatory genes in the growth process of cashmere fiber, largely affects the quality of cashmere. Methods: In this study, t...

  • Article
  • Open Access
2 Citations
894 Views
10 Pages

Dopaminergic Modulation of Conscientiousness: DRD2 rs1799732 and Personality Traits in Elite Mixed Martial Arts Athletes

  • Milena Lachowicz,
  • Remigiusz Recław,
  • Krzysztof Chmielowiec,
  • Jolanta Chmielowiec,
  • Kinga Łosińska,
  • Aleksandra Suchanecka,
  • Jolanta Masiak and
  • Anna Grzywacz

18 June 2025

Background: Personality traits, particularly Conscientiousness, are recognised as crucial psychological factors contributing to success in elite-level athletes. Emerging evidence suggests that individual differences in these traits are influenced by...

  • Article
  • Open Access
733 Views
11 Pages

18 June 2025

Background/Objectives: To overcome the limitations imposed by bacterial blight on widely adopted indica–japonica hybrid rice, this study employed molecular design breeding strategies to develop a resistant germplasm. Methods: Through convention...

  • Review
  • Open Access
1,223 Views
23 Pages

18 June 2025

Aquaculture has become a crucial component of global food production, yet catfish (10.8% of global finfish production) breeding programs often lack sufficient genetic data to fully utilize their production potential. In the last 15 years, there have...

  • Article
  • Open Access
925 Views
20 Pages

Molecular Characterization of CnHd3a and Spatial Expression of Its Alternative Splicing Forms Associated with Flowering Transition and Flower Development in Coconut Palm (Cocos nucifera L.)

  • Pariya Maneeprasert,
  • Siriwan Thaisakun,
  • Theerachai Thanananta,
  • Narumol Thanananta,
  • Noppamart Lokkamlue and
  • Chareerat Mongkolsiriwatana

18 June 2025

Background: The flowering transition is a critical process determining the onset of reproductive development and fruit production. The molecular mechanisms underlying this process in coconuts are poorly understood; however, recent studies have identi...

  • Article
  • Open Access
1,248 Views
21 Pages

Bioinformatics-Driven Identification of Ferroptosis-Related Gene Signatures Distinguishing Active and Latent Tuberculosis

  • Rakesh Arya,
  • Hemlata Shakya,
  • Viplov Kumar Biswas,
  • Gyanendra Kumar,
  • Sumendra Yogarayan,
  • Harish Kumar Shakya and
  • Jong-Joo Kim

18 June 2025

Background: Tuberculosis (TB) remains a major global public health challenge, and diagnosing it can be difficult due to issues such as distinguishing active TB from latent TB infection (LTBI), as well as the sample collection process, which is often...

  • Article
  • Open Access
1 Citations
3,114 Views
21 Pages

Identification of Gene Expression Biomarkers Predictive of Latent Tuberculosis Infection Using Machine Learning Approaches

  • Youssra Boumait,
  • Boutaina Ettetuani,
  • Manal Chrairi,
  • Afaf Lamzouri and
  • Rajaa Chahboune

18 June 2025

Latent tuberculosis infection (LTBi) affects nearly a quarter of the global population, yet current diagnostic methods are limited by low sensitivity and specificity. This study applied an integrative bioinformatics framework, incorporating machine l...

  • Article
  • Open Access
1,610 Views
9 Pages

Results of Chromosomal Microarray Need to Always Be Checked by (Molecular) Cytogenetics—Even If They Seem to Be Simple Deletions

  • Thomas Liehr,
  • Sylke Singer,
  • Ulrike Mau-Holzmann,
  • Stefanie Kankel,
  • Niklas Padutsch,
  • Luisa Person,
  • Eva Daumiller and
  • Uwe Kornak

17 June 2025

Background/Objectives: Chromosome microarrays (CMAs) tend to be used as the first line test or as a test that does not require confirmation or verification by a second test. However, to understand the implications of a duplication or deletion for a f...

  • Article
  • Open Access
798 Views
14 Pages

The Single Nucleotide Substitution T → A rs2072580 Damages the CREB1 Binding Site in the Bidirectional SART3/ISCU Promoter

  • Arina Degtyareva,
  • Elena Antontseva,
  • Anastasia Evseenko,
  • Konstantin Orishchenko and
  • Tatiana Merkulova

17 June 2025

Background/Objectives: The regulatory SNPs (rSNPs) that disturb the binding of transcription factors (TFs) and alter the transcription levels of genes play a paramount role in the formation of different traits and are associated with many pathologies...

  • Article
  • Open Access
744 Views
14 Pages

Incidence of Homozygous SMN2 Deletion in Japan: Cross-Reactivity of SMN2 Primers with SMN1 Sequence Causes False Negatives in Real-Time PCR Screening

  • Makoto Sakima,
  • Yoshihiro Bouike,
  • Shin-Ichi Wada,
  • Masami Nakamae,
  • Yoriko Noguchi,
  • Ryosuke Bo,
  • Hiroyuki Awano,
  • Jumpei Oba and
  • Hisahide Nishio

16 June 2025

Background: SMN1 and SMN2 are causative and modifier genes, respectively, for spinal muscular atrophy (SMA). The incidence of SMN1 homozygous deletion in Japan is 1 in 20,000. However, the incidence of SMN2 homozygous deletion in Japan remains unknow...

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Genes - ISSN 2073-4425