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Genes, Volume 15, Issue 2

February 2024 - 120 articles

Cover Story: Spitz melanocytic tumors are a diverse group of neoplasms, ranging from totally benign to overtly malignant. Although morphology remains the cornerstone of surgical pathology practice, incorporating immunohistochemical and molecular genetic findings has been reaching grounds to achieve a timely and accurate diagnosis. This applies particularly in the case of Spitz tumors, since most of them are driven by oncogenic fusions. The cover composite depicts a melanocytic neoplasm with typical morphologic features of Spitz nevus in the central area. On the left, immunohistochemical expression of ROS1 protein can be detected in Spitz neoplasms with ROS1 fusions. On the right, break apart FISH with probes for ROS1 demonstrate breakage of red and green signal, confirming a ROS1 gene rearrangement. View this paper
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Articles (120)

  • Feature Paper
  • Article
  • Open Access
2 Citations
3,360 Views
11 Pages

Optimization of HIV Sequencing Method Using Vela Sentosa Library on Miseq Ilumina Platform

  • Nasserdine Papa Mze,
  • Cécile Fernand-Laurent,
  • Solen Daugabel,
  • Olfa Zanzouri and
  • Stéphanie Marque Juillet

19 February 2024

Genotypic testing is often recommended to improve the management of patients infected with human immunodeficiency virus (HIV). To help combat this major pandemic, next-generation sequencing (NGS) techniques are widely used to analyse resistance to an...

  • Article
  • Open Access
8 Citations
2,336 Views
12 Pages

Satellitome Analysis in the Southern Lapwing (Vanellus chilensis) Genome: Implications for SatDNA Evolution in Charadriiform Birds

  • Rafael Kretschmer,
  • Gustavo A. Toma,
  • Geize Aparecida Deon,
  • Natalia dos Santos,
  • Rodrigo Zeni dos Santos,
  • Ricardo Utsunomia,
  • Fabio Porto-Foresti,
  • Ricardo José Gunski,
  • Analía Del Valle Garnero and
  • Thomas Liehr
  • + 3 authors

19 February 2024

Vanellus (Charadriidae; Charadriiformes) comprises around 20 species commonly referred to as lapwings. In this study, by integrating cytogenetic and genomic approaches, we assessed the satellite DNA (satDNA) composition of one typical species, Vanell...

  • Article
  • Open Access
3 Citations
2,354 Views
15 Pages

Identification of Novel QTL for Mercury Accumulation in Maize Using an Enlarged SNP Panel

  • Jionghao Gao,
  • Jianxin Li,
  • Jihong Zhang,
  • Yan Sun,
  • Xiaolong Ju,
  • Wenlong Li,
  • Haiyang Duan,
  • Zhengjie Xue,
  • Li Sun and
  • Javed Hussain Sahito
  • + 3 authors

19 February 2024

Mercury (Hg) pollution not only poses a threat to the environment but also adversely affects the growth and development of plants, with potential repercussions for animals and humans through bioaccumulation in the food chain. Maize, a crucial source...

  • Article
  • Open Access
2 Citations
3,656 Views
14 Pages

Further Delineation of Clinical Phenotype of ZMYND11 Variants in Patients with Neurodevelopmental Dysmorphic Syndrome

  • Aleksandra Bodetko,
  • Joanna Chrzanowska,
  • Malgorzata Rydzanicz,
  • Agnieszka Borys-Iwanicka,
  • Pawel Karpinski,
  • Joanna Bladowska,
  • Rafal Ploski and
  • Robert Smigiel

19 February 2024

Intellectual disability with speech delay and behavioural abnormalities, as well as hypotonia, seizures, feeding difficulties and craniofacial dysmorphism, are the main symptoms associated with pathogenic variants of the ZMYND11 gene. The range of cl...

  • Article
  • Open Access
2,340 Views
11 Pages

GiOPARK Project: The Genetic Study of Parkinson’s Disease in the Croatian Population

  • Valentino Rački,
  • Gaber Bergant,
  • Eliša Papić,
  • Anja Kovanda,
  • Mario Hero,
  • Gloria Rožmarić,
  • Nada Starčević Čizmarević,
  • Smiljana Ristić,
  • Saša Ostojić and
  • Miljenko Kapović
  • + 3 authors

19 February 2024

Parkinson’s disease is a neurological disorder that affects motor function, autonomic functions, and cognitive abilities. It is likely that both genetic and environmental factors, along with age, contribute to the cause. However, there is no co...

  • Article
  • Open Access
5 Citations
2,355 Views
16 Pages

18 February 2024

This study presents the complete mitochondrial genome (mitogenome) of Litostrophus scaber, which is the first mitogenome of the genus Litostrophus. The mitogenome is a circular molecule with a length of 15,081 bp. The proportion of adenine and thymin...

  • Article
  • Open Access
6 Citations
3,354 Views
12 Pages

Improving Genomic Predictions in Multi-Breed Cattle Populations: A Comparative Analysis of BayesR and GBLUP Models

  • Haoran Ma,
  • Hongwei Li,
  • Fei Ge,
  • Huqiong Zhao,
  • Bo Zhu,
  • Lupei Zhang,
  • Huijiang Gao,
  • Lingyang Xu,
  • Junya Li and
  • Zezhao Wang

18 February 2024

Numerous studies have shown that combining populations from similar or closely related genetic breeds improves the accuracy of genomic predictions (GP). Extensive experimentation with diverse Bayesian and genomic best linear unbiased prediction (GBLU...

  • Review
  • Open Access
2,828 Views
12 Pages

18 February 2024

An abundance of antisense promoters in the vicinity of the transcriptional start site of coding genes suggests that they play an important role in gene regulation. The divergent transcription of housekeeping genes by a common central promoter region...

  • Review
  • Open Access
5 Citations
4,303 Views
18 Pages

Allelic Variations in Vernalization (Vrn) Genes in Triticum spp.

  • Sanaz Afshari-Behbahanizadeh,
  • Damiano Puglisi,
  • Salvatore Esposito and
  • Pasquale De Vita

17 February 2024

Rapid climate changes, with higher warming rates during winter and spring seasons, dramatically affect the vernalization requirements, one of the most critical processes for the induction of wheat reproductive growth, with severe consequences on flow...

  • Article
  • Open Access
2 Citations
2,030 Views
10 Pages

The Identification of Goat KCNJ15 Gene Copy Number Variation and Its Association with Growth Traits

  • Jiahao Zhao,
  • Zhe Liu,
  • Xianwei Wang,
  • Xiaoling Xin,
  • Lei Du,
  • Huangqing Zhao,
  • Qingming An,
  • Xiaoting Ding,
  • Zijing Zhang and
  • Eryao Wang
  • + 2 authors

17 February 2024

(1) Background: Copy number variation (CNV) is a critical component of genome structural variation and has garnered significant attention. High-throughput screening of the KCNJ15 gene has revealed a correlation between the CNV region and the growth t...

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Genes - ISSN 2073-4425