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Genes, Volume 13, Issue 12

December 2022 - 241 articles

Cover Story: Clostridioides difficile is an obligate anaerobic pathogen that is among the most common causes of healthcare-associated infections. It poses a global threat due to the clinical outcomes of infection and resistance to antibiotics recommended by international guidelines for its eradication. In particular, C. difficile infection can lead to fulminant colitis associated with shock, hypotension, megacolon, and, in severe cases, death. It is therefore of the utmost urgency to fully characterize this pathogen and to better understand its spread, in order to reduce infection rates and improve therapy success. Our work focuses on the genetic evolution of C. difficile virulence, antimicrobial resistance, the molecular typing techniques used to characterize this pathogen, the global distribution of the most common ribotypes, and novel genetic engineering strategies to control this threat. View this paper
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Articles (241)

  • Review
  • Open Access
17 Citations
6,422 Views
11 Pages

Impact of X-Linked Hypophosphatemia on Muscle Symptoms

  • Cecilia Romagnoli,
  • Teresa Iantomasi and
  • Maria Luisa Brandi

19 December 2022

X-linked hypophosphatemia (XLH) is the most common hereditary form of rickets and deficiency of renal tubular phosphate transport in humans. XLH is caused by the inactivation of mutations within the phosphate-regulating endopeptidase homolog X-linked...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,461 Views
16 Pages

Population Genetics and Anastomosis Group’s Geographical Distribution of Rhizoctonia solani Associated with Soybean

  • Aqleem Abbas,
  • Xiangling Fang,
  • Shehzad Iqbal,
  • Syed Atif Hasan Naqvi,
  • Yasir Mehmood,
  • Muhammad Junaid Rao,
  • Zeshan Hassan,
  • Roberto Miño Ortiz,
  • Alaa Baazeem and
  • Mahmoud Moustafa
  • + 2 authors

19 December 2022

Rhizoctonia solani is a species complex composed of many genetically diverse anastomosis groups (AG) and their subgroups. It causes economically important diseases of soybean worldwide. However, the global genetic diversity and distribution of R. sol...

  • Article
  • Open Access
6 Citations
2,689 Views
13 Pages

Whole-Genome Sequence Analysis Reveals the Origin of the Chakouyi Horse

  • Ying Li,
  • Yu Liu,
  • Min Wang,
  • Xiaoran Lin,
  • Yuanyuan Li,
  • Tao Yang,
  • Mo Feng,
  • Yao Ling and
  • Chunjiang Zhao

19 December 2022

The Chakouyi horse is an ancient Chinese indigenous horse breed distributed in Gansu Province in northwestern China, and is also one of the key breeds protected by the government. However, the origin of the Chakouyi horse remains unclear. As it is di...

  • Article
  • Open Access
3 Citations
2,958 Views
12 Pages

19 December 2022

Using radiogenomics methods, the differences between tumor imaging data and genetic data in Chinese and Western breast cancer (BC) patients were analyzed, and the correlation between phenotypic data and genetic data was explored. In this paper, we an...

  • Article
  • Open Access
6 Citations
2,551 Views
14 Pages

19 December 2022

Metallothionein (MT) is a multifunctional inducible protein in animals, plants, and microorganisms. MT is rich in cysteine residues (10−30%), can combine with metal ions, has a low molecular weight, and plays an essential biological role in var...

  • Article
  • Open Access
13 Citations
3,029 Views
13 Pages

Marker-Assisted Pyramiding of CRa and CRd Genes to Improve the Clubroot Resistance of Brassica rapa

  • Xiaonan Li,
  • Yingxia Wei,
  • Yingmei Ma,
  • Guizhu Cao,
  • Siwen Ma,
  • Tianyu Zhang,
  • Zongxiang Zhan and
  • Zhongyun Piao

19 December 2022

Clubroot, caused by Plasmodiophora brassicae, is an economically important soil-borne disease that threatens Brassicaceae crops worldwide. In recent years, the incidence area of Chinese cabbage (Brassica rapa ssp. pekinensis) clubroot disease has inc...

  • Article
  • Open Access
6 Citations
4,381 Views
23 Pages

In Silico Prediction of Hub Genes Involved in Diabetic Kidney and COVID-19 Related Disease by Differential Gene Expression and Interactome Analysis

  • Ulises Osuna-Martinez,
  • Katia Aviña-Padilla,
  • Vicente Olimon-Andalon,
  • Carla Angulo-Rojo,
  • Alma Guadron-Llanos,
  • Jose Carlos Rivas-Ferreira,
  • Francisco Urrea and
  • Loranda Calderon-Zamora

19 December 2022

Diabetic kidney disease (DKD) is a frequently chronic kidney pathology derived from diabetes comorbidity. This condition has irreversible damage and its risk factor increases with SARS-CoV-2 infection. The prognostic outcome for diabetic patients wit...

  • Article
  • Open Access
5 Citations
2,191 Views
12 Pages

19 December 2022

Opisthopappus C. Shih is a rare genus of the Asteraceae family native to the Taihang Mountains in China. Due to the narrow distribution area, poor reproduction ability and human harvesting, Opisthopappus is threatened by extinction. However, the limi...

  • Article
  • Open Access
10 Citations
2,306 Views
10 Pages

19 December 2022

Identification of new, effective disease resistance genes is a very important aspect of plant breeding. Also important is the precise location of individual loci and tagging them with DNA markers for marker assisted selection. The aim of the present...

  • Article
  • Open Access
7 Citations
2,543 Views
13 Pages

Association of Inherited Copy Number Variation in ADAM3A and ADAM5 Pseudogenes with Oropharynx Cancer Risk and Outcome

  • Juliana Carron,
  • Caroline Torricelli,
  • Janet Keller Silva,
  • Yichuan Liu,
  • Renata Pellegrino,
  • Carmen Silvia Passos Lima and
  • Gustavo Jacob Lourenço

19 December 2022

Inherited copy number variations (CNVs) can provide valuable information for cancer susceptibility and prognosis. However, their association with oropharynx squamous cell carcinoma (OPSCC) is still poorly studied. Using microarrays analysis, we ident...

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Genes - ISSN 2073-4425