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Genes, Volume 12, Issue 1

January 2021 - 125 articles

Cover Story: A portrait of the current state of biomarker knowledge for clinical management of cancer patients. Tumor therapy based on personalized treatment options could improve the overall survival of cancer patients. Knowledge about biomarkers is a prerequisite for using personalized treatment such as immune-based therapies or targeted drugs. Due to unprecedented technological developments, coupled with novel holistic approaches in translational research, a multitude of biomarkers at genomic, transcriptomic, proteomic, and immunologic levels have been discovered. One example is the different immune milieu for microsatellite instable (MSI) and microsatellite stabile (MSS) pancreatic cancer. The differences in PD-L1 expression level as well as different number of immune cells in the tumor microenvironment of the two groups of pancreatic cancer are the reason pancreatic cancer patients with MSI react differently to chemotherapy. View this paper
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Articles (125)

  • Article
  • Open Access
17 Citations
5,487 Views
14 Pages

Merging Genomics and Transcriptomics for Predicting Fusarium Head Blight Resistance in Wheat

  • Sebastian Michel,
  • Christian Wagner,
  • Tetyana Nosenko,
  • Barbara Steiner,
  • Mina Samad-Zamini,
  • Maria Buerstmayr,
  • Klaus Mayer and
  • Hermann Buerstmayr

19 January 2021

Genomic selection with genome-wide distributed molecular markers has evolved into a well-implemented tool in many breeding programs during the last decade. The resistance against Fusarium head blight (FHB) in wheat is probably one of the most thoroug...

  • Article
  • Open Access
6 Citations
4,260 Views
14 Pages

19 January 2021

Pseudomonas mendocina is an environmental bacterium, rarely isolated in clinical specimens, although it has been described as producing endocarditis and sepsis. Little is known about its genome. Whole genome sequencing can be used to learn about the...

  • Article
  • Open Access
20 Citations
4,848 Views
11 Pages

Sex Chromosome Turnover in Bent-Toed Geckos (Cyrtodactylus)

  • Shannon E. Keating,
  • Madison Blumer,
  • L. Lee Grismer,
  • Aung Lin,
  • Stuart V. Nielsen,
  • Myint Kyaw Thura,
  • Perry L. Wood,
  • Evan S. H. Quah and
  • Tony Gamble

19 January 2021

Lizards and snakes (squamates) are known for their varied sex determining systems, and gecko lizards are especially diverse, having evolved sex chromosomes independently multiple times. While sex chromosomes frequently turnover among gecko genera, in...

  • Review
  • Open Access
22 Citations
4,495 Views
21 Pages

Suprabasin—A Review

  • Miroslav Pribyl,
  • Zdenek Hodny and
  • Iva Kubikova

18 January 2021

Among the ~22,000 human genes, very few remain that have unknown functions. One such example is suprabasin (SBSN). Originally described as a component of the cornified envelope, the function of stratified epithelia-expressed SBSN is unknown. Both the...

  • Article
  • Open Access
27 Citations
6,968 Views
28 Pages

Dissecting the Polygenic Basis of Cold Adaptation Using Genome-Wide Association of Traits and Environmental Data in Douglas-fir

  • Amanda R. De La Torre,
  • Benjamin Wilhite,
  • Daniela Puiu,
  • John Bradley St. Clair,
  • Marc W. Crepeau,
  • Steven L. Salzberg,
  • Charles H. Langley,
  • Brian Allen and
  • David B. Neale

18 January 2021

Understanding the genomic and environmental basis of cold adaptation is key to understand how plants survive and adapt to different environmental conditions across their natural range. Univariate and multivariate genome-wide association (GWAS) and ge...

  • Article
  • Open Access
68 Citations
13,428 Views
26 Pages

Defining the Rhizobium leguminosarum Species Complex

  • J. Peter W. Young,
  • Sara Moeskjær,
  • Alexey Afonin,
  • Praveen Rahi,
  • Marta Maluk,
  • Euan K. James,
  • Maria Izabel A. Cavassim,
  • M. Harun-or Rashid,
  • Aregu Amsalu Aserse and
  • Benjamin J. Perry
  • + 16 authors

18 January 2021

Bacteria currently included in Rhizobium leguminosarum are too diverse to be considered a single species, so we can refer to this as a species complex (the Rlc). We have found 429 publicly available genome sequences that fall within the Rlc and these...

  • Article
  • Open Access
23 Citations
4,863 Views
11 Pages

Litter Size of Sheep (Ovis aries): Inbreeding Depression and Homozygous Regions

  • Lin Tao,
  • Xiaoyun He,
  • Xiangyu Wang,
  • Ran Di and
  • Mingxing Chu

18 January 2021

Ovine litter size (LS) is an important trait showing variability within breeds. It remains largely unknown whether inbreeding depression on LS exists based on genomic homozygous regions, and whether the homozygous regions resulted from inbreeding are...

  • Review
  • Open Access
7 Citations
4,871 Views
21 Pages

Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches

  • Marta García-López,
  • Joaquín Arenas and
  • M. Esther Gallardo

18 January 2021

Inherited optic neuropathies share visual impairment due to the degeneration of retinal ganglion cells (RGCs) as the hallmark of the disease. This group of genetic disorders are caused by mutations in nuclear genes or in the mitochondrial DNA (mtDNA)...

  • Article
  • Open Access
15 Citations
5,183 Views
18 Pages

Patterns of Epigenetic Diversity in Two Sympatric Fish Species: Genetic vs. Environmental Determinants

  • Laura Fargeot,
  • Géraldine Loot,
  • Jérôme G. Prunier,
  • Olivier Rey,
  • Charlotte Veyssière and
  • Simon Blanchet

16 January 2021

Epigenetic components are hypothesized to be sensitive to the environment, which should permit species to adapt to environmental changes. In wild populations, epigenetic variation should therefore be mainly driven by environmental variation. Here, we...

  • Article
  • Open Access
58 Citations
13,039 Views
18 Pages

Real-Time Culture-Independent Microbial Profiling Onboard the International Space Station Using Nanopore Sequencing

  • Sarah Stahl-Rommel,
  • Miten Jain,
  • Hang N. Nguyen,
  • Richard R. Arnold,
  • Serena M. Aunon-Chancellor,
  • Gretta Marie Sharp,
  • Christian L. Castro,
  • Kristen K. John,
  • Sissel Juul and
  • Daniel J. Turner
  • + 5 authors

16 January 2021

For the past two decades, microbial monitoring of the International Space Station (ISS) has relied on culture-dependent methods that require return to Earth for analysis. This has a number of limitations, with the most significant being bias towards...

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Genes - ISSN 2073-4425