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Review

Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches

1
Grupo de Investigación Traslacional con Células iPS, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), 28041 Madrid, Spain
2
Grupo de Enfermedades Raras, Mitocondriales y Neuromusculares, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), 28041 Madrid, Spain
3
Centro de Investigación Biomédica en Red (CIBERER), Madrid, Spain
*
Author to whom correspondence should be addressed.
Genes 2021, 12(1), 112; https://doi.org/10.3390/genes12010112
Received: 14 December 2020 / Revised: 10 January 2021 / Accepted: 14 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Application Status and Development Prospects of Stem Cells)
Inherited optic neuropathies share visual impairment due to the degeneration of retinal ganglion cells (RGCs) as the hallmark of the disease. This group of genetic disorders are caused by mutations in nuclear genes or in the mitochondrial DNA (mtDNA). An impaired mitochondrial function is the underlying mechanism of these diseases. Currently, optic neuropathies lack an effective treatment, and the implementation of induced pluripotent stem cell (iPSC) technology would entail a huge step forward. The generation of iPSC-derived RGCs would allow faithfully modeling these disorders, and these RGCs would represent an appealing platform for drug screening as well, paving the way for a proper therapy. Here, we review the ongoing two-dimensional (2D) and three-dimensional (3D) approaches based on iPSCs and their applications, taking into account the more innovative technologies, which include tissue engineering or microfluidics. View Full-Text
Keywords: induced pluripotent stem cells; iPSCs; iPS; optic neuropathies; optic atrophy; mitochondriopathy; retinal ganglion cells; organoids; tissue engineering induced pluripotent stem cells; iPSCs; iPS; optic neuropathies; optic atrophy; mitochondriopathy; retinal ganglion cells; organoids; tissue engineering
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MDPI and ACS Style

García-López, M.; Arenas, J.; Gallardo, M.E. Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches. Genes 2021, 12, 112. https://doi.org/10.3390/genes12010112

AMA Style

García-López M, Arenas J, Gallardo ME. Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches. Genes. 2021; 12(1):112. https://doi.org/10.3390/genes12010112

Chicago/Turabian Style

García-López, Marta, Joaquín Arenas, and M. E. Gallardo 2021. "Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches" Genes 12, no. 1: 112. https://doi.org/10.3390/genes12010112

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