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Genes, Volume 12, Issue 1

2021 January - 125 articles

Cover Story: A portrait of the current state of biomarker knowledge for clinical management of cancer patients. Tumor therapy based on personalized treatment options could improve the overall survival of cancer patients. Knowledge about biomarkers is a prerequisite for using personalized treatment such as immune-based therapies or targeted drugs. Due to unprecedented technological developments, coupled with novel holistic approaches in translational research, a multitude of biomarkers at genomic, transcriptomic, proteomic, and immunologic levels have been discovered. One example is the different immune milieu for microsatellite instable (MSI) and microsatellite stabile (MSS) pancreatic cancer. The differences in PD-L1 expression level as well as different number of immune cells in the tumor microenvironment of the two groups of pancreatic cancer are the reason pancreatic cancer patients with MSI react differently to chemotherapy. View this paper
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Articles (125)

  • Article
  • Open Access
10 Citations
3,841 Views
12 Pages

Morphological Abnormalities and Gene Expression Changes Caused by High Incubation Temperatures in Zebrafish Xenografts with Human Cancer Cells

  • Pablo Cabezas-Sainz,
  • Carlos Coppel,
  • Alba Pensado-López,
  • Pedro Fernandez,
  • Laura Muinelo-Romay,
  • Rafael López-López,
  • Juan A. Rubiolo and
  • Laura Sánchez

19 January 2021

Published studies show that most of the human cancer xenograft studies in zebrafish embryos have used incubation temperatures in the range of 32–34 °C for 3–6 days post-injection, trying to find a compromise temperature between the ze...

  • Article
  • Open Access
18 Citations
5,587 Views
14 Pages

Merging Genomics and Transcriptomics for Predicting Fusarium Head Blight Resistance in Wheat

  • Sebastian Michel,
  • Christian Wagner,
  • Tetyana Nosenko,
  • Barbara Steiner,
  • Mina Samad-Zamini,
  • Maria Buerstmayr,
  • Klaus Mayer and
  • Hermann Buerstmayr

19 January 2021

Genomic selection with genome-wide distributed molecular markers has evolved into a well-implemented tool in many breeding programs during the last decade. The resistance against Fusarium head blight (FHB) in wheat is probably one of the most thoroug...

  • Article
  • Open Access
6 Citations
4,377 Views
14 Pages

19 January 2021

Pseudomonas mendocina is an environmental bacterium, rarely isolated in clinical specimens, although it has been described as producing endocarditis and sepsis. Little is known about its genome. Whole genome sequencing can be used to learn about the...

  • Article
  • Open Access
20 Citations
4,955 Views
11 Pages

Sex Chromosome Turnover in Bent-Toed Geckos (Cyrtodactylus)

  • Shannon E. Keating,
  • Madison Blumer,
  • L. Lee Grismer,
  • Aung Lin,
  • Stuart V. Nielsen,
  • Myint Kyaw Thura,
  • Perry L. Wood,
  • Evan S. H. Quah and
  • Tony Gamble

19 January 2021

Lizards and snakes (squamates) are known for their varied sex determining systems, and gecko lizards are especially diverse, having evolved sex chromosomes independently multiple times. While sex chromosomes frequently turnover among gecko genera, in...

  • Article
  • Open Access
7 Citations
4,018 Views
15 Pages

HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas

  • Yiyun Sun,
  • Dandan Xu,
  • Chundong Zhang,
  • Yitao Wang,
  • Lian Zhang,
  • Deqian Qiao,
  • Youquan Bu and
  • Ying Zhang

19 January 2021

We previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter. This gene pair synergistically promoted the developm...

  • Editorial
  • Open Access
6 Citations
4,179 Views
3 Pages

Embryo Genetics

  • Carmen Rubio and
  • Carlos Simón

19 January 2021

Advances in embryo and reproductive genetics have influenced clinical approaches to overcome infertility. Since the 1990s, many attempts have been made to decipher the genetic causes of infertility and to understand the role of chromosome aneuploidie...

  • Article
  • Open Access
43 Citations
5,587 Views
15 Pages

Weighted Single-Step GWAS Identified Candidate Genes Associated with Growth Traits in a Duroc Pig Population

  • Donglin Ruan,
  • Zhanwei Zhuang,
  • Rongrong Ding,
  • Yibin Qiu,
  • Shenping Zhou,
  • Jie Wu,
  • Cineng Xu,
  • Linjun Hong,
  • Sixiu Huang and
  • Jie Yang
  • + 3 authors

19 January 2021

Growth traits are important economic traits of pigs that are controlled by several major genes and multiple minor genes. To better understand the genetic architecture of growth traits, we performed a weighted single-step genome-wide association study...

  • Article
  • Open Access
17 Citations
3,722 Views
18 Pages

19 January 2021

Halotolerant lipolytic enzymes have gained growing interest, due to potential applications under harsh conditions, such as hypersalinity and presence of organic solvents. In this study, a lipolytic gene, est56, encoding 287 amino acids was identified...

  • Article
  • Open Access
33 Citations
5,809 Views
13 Pages

The Desmin (DES) Mutation p.A337P Is Associated with Left-Ventricular Non-Compaction Cardiomyopathy

  • Olga Kulikova,
  • Andreas Brodehl,
  • Anna Kiseleva,
  • Roman Myasnikov,
  • Alexey Meshkov,
  • Caroline Stanasiuk,
  • Anna Gärtner,
  • Mikhail Divashuk,
  • Evgeniia Sotnikova and
  • Oxana Drapkina
  • + 8 authors

19 January 2021

Here, we present a small Russian family, where the index patient received a diagnosis of left-ventricular non-compaction cardiomyopathy (LVNC) in combination with a skeletal myopathy. Clinical follow-up analysis revealed a LVNC phenotype also in her...

  • Article
  • Open Access
13 Citations
4,956 Views
17 Pages

19 January 2021

Mitochondrial integrity and homeostasis in the midgut are key factors controlling mosquito fitness and anti-pathogen resistance. Targeting genes that regulate mitochondrial dynamics represents a potential strategy for limiting mosquito-borne diseases...

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Genes - ISSN 2073-4425