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Cells, Volume 9, Issue 8

August 2020 - 171 articles

Cover Story: Crosstalk between Schwann cells and neurons, involving protein kinase type C-ε (PKCε), plays an important role in the sensitization of primary afferent nociceptors. Schwann cells possess the enzymatic machinery able to synthetize the progesterone metabolite allopregnanolone (ALLO) and tonically release it. ALLO autocrinally increases the expression and protein levels of the brain-derived neurotrophic factor (BDNF). Successively, being released by Schwann cells, BDNF paracrinally activates PKCε in dorsal root ganglia neurons. PKCε is renowned for increasing neuronal excitability via the phosphorylation of several ion channels, promoting the hyperalgesic priming of peripheral fibers, in turn leading to the modulation of noxious stimuli to the central nervous system. These mechanisms emphasize promising targets for inhibiting the onset and chronification of neuropathic pain. View this paper
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Articles (171)

  • Article
  • Open Access
9 Citations
5,262 Views
17 Pages

Exposure of Human Skin Organoids to Low Genotoxic Stress Can Promote Epithelial-to-Mesenchymal Transition in Regenerating Keratinocyte Precursor Cells

  • Sophie Cavallero,
  • Renata Neves Granito,
  • Daniel Stockholm,
  • Peggy Azzolin,
  • Michèle T. Martin and
  • Nicolas O. Fortunel

18 August 2020

For the general population, medical diagnosis is a major cause of exposure to low genotoxic stress, as various imaging techniques deliver low doses of ionizing radiation. Our study investigated the consequences of low genotoxic stress on a keratinocy...

  • Review
  • Open Access
20 Citations
4,565 Views
16 Pages

The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import

  • Sofiya Tsimbalyuk,
  • Emily M. Cross,
  • Mikayla Hoad,
  • Camilla M. Donnelly,
  • Justin A. Roby and
  • Jade K. Forwood

18 August 2020

Nipah and Hendra viruses are highly pathogenic, zoonotic henipaviruses that encode proteins that inhibit the host’s innate immune response. The W protein is one of four products encoded from the P gene and binds a number of host proteins to regulate...

  • Article
  • Open Access
20 Citations
5,376 Views
16 Pages

Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells

  • Sebastián Alarcón,
  • María de los Ángeles Toro,
  • Carolina Villarreal,
  • Rómulo Melo,
  • Rodrigo Fernández,
  • Angel Ayuso Sacido,
  • Daniel Uribe,
  • Rody San Martín and
  • Claudia Quezada

18 August 2020

Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular aden...

  • Article
  • Open Access
35 Citations
4,046 Views
15 Pages

Impact of Anticoagulation and Sample Processing on the Quantification of Human Blood-Derived microRNA Signatures

  • Marion Mussbacher,
  • Teresa L. Krammer,
  • Stefan Heber,
  • Waltraud C. Schrottmaier,
  • Stephan Zeibig,
  • Hans-Peter Holthoff,
  • David Pereyra,
  • Patrick Starlinger,
  • Matthias Hackl and
  • Alice Assinger

18 August 2020

Blood-derived microRNA signatures have emerged as powerful biomarkers for predicting and diagnosing cardiovascular disease, cancer, and metabolic disorders. Platelets and platelet-derived microvesicles are a major source of microRNAs. We have previou...

  • Review
  • Open Access
17 Citations
5,468 Views
19 Pages

Stemness Potency of Human Gingival Cells—Application in Anticancer Therapies and Clinical Trials

  • Katarzyna Stefańska,
  • Katarzyna Mehr,
  • Maria Wieczorkiewicz,
  • Magdalena Kulus,
  • Ana Angelova Volponi,
  • Jamil A. Shibli,
  • Paul Mozdziak,
  • Mariusz T. Skowroński,
  • Paweł Antosik and
  • Jędrzej M. Jaśkowski
  • + 3 authors

18 August 2020

Gingivae, as the part of periodontium, are involved in tooth support and possess the ability to heal rapidly, without scar formation. Recently, dental tissues have been identified as a potential source of mesenchymal stem cells (MSCs) and several pop...

  • Article
  • Open Access
24 Citations
5,246 Views
15 Pages

MiRNA let-7 from TPO(+) Extracellular Vesicles is a Potential Marker for a Differential Diagnosis of Follicular Thyroid Nodules

  • Lidia Zabegina,
  • Inga Nazarova,
  • Margarita Knyazeva,
  • Nadezhda Nikiforova,
  • Maria Slyusarenko,
  • Sergey Titov,
  • Dmitry Vasilyev,
  • Ilya Sleptsov and
  • Anastasia Malek

18 August 2020

Background: The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a p...

  • Correction
  • Open Access
3 Citations
2,541 Views
5 Pages

Correction: Yao, Y., et al. Activation of Slit2/Robo1 Signaling Promotes Tumor Metastasis in Colorectal Carcinoma through Activation of the TGF-β/Smads Pathway. Cells 2019, 8, 635

  • Yuying Yao,
  • Zijun Zhou,
  • Liuyou Li,
  • Junchen Li,
  • Lixun Huang,
  • Jiangchao Li,
  • Cuiling Qi,
  • Lingyun Zheng,
  • Lijing Wang and
  • Qian-Qian Zhang

18 August 2020

The author wishes to make the following correction to this paper [...]

  • Review
  • Open Access
379 Citations
35,168 Views
31 Pages

17 August 2020

The intestinal barrier is essential in human health and constitutes the interface between the outside and the internal milieu of the body. A functional intestinal barrier allows absorption of nutrients and fluids but simultaneously prevents harmful s...

  • Article
  • Open Access
18 Citations
4,907 Views
19 Pages

TLR3-Dependent Activation of TLR2 Endogenous Ligands via the MyD88 Signaling Pathway Augments the Innate Immune Response

  • Hellen S. Teixeira,
  • Jiawei Zhao,
  • Ethan Kazmierski,
  • Denis F. Kinane and
  • Manjunatha R. Benakanakere

17 August 2020

The role of the adaptor molecule MyD88 is thought to be independent of Toll-like receptor 3 (TLR3) signaling. In this report, we demonstrate a previously unknown role of MyD88 in TLR3 signaling in inducing endogenous ligands of TLR2 to elicit innate...

  • Review
  • Open Access
32 Citations
8,735 Views
14 Pages

Zebrafish: A Suitable Tool for the Study of Cell Signaling in Bone

  • Maria Teresa Valenti,
  • Giulia Marchetto,
  • Monica Mottes and
  • Luca Dalle Carbonare

17 August 2020

In recent decades, many studies using the zebrafish model organism have been performed. Zebrafish, providing genetic mutants and reporter transgenic lines, enable a great number of studies aiming at the investigation of signaling pathways involved in...

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Cells - ISSN 2073-4409