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Phase Diagram of Purified CNS Myelin Reveals Continuous Transformation between Expanded and Compacted Lamellar States
Review

Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism

Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY 12208, USA
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Cells 2020, 9(4), 812; https://doi.org/10.3390/cells9040812
Received: 5 March 2020 / Revised: 24 March 2020 / Accepted: 25 March 2020 / Published: 27 March 2020
(This article belongs to the Special Issue Structure and Function of Healthy and Diseased Myelin)
Myelin is critical for the proper function of the nervous system and one of the most complex cell–cell interactions of the body. Myelination allows for the rapid conduction of action potentials along axonal fibers and provides physical and trophic support to neurons. Myelin contains a high content of lipids, and the formation of the myelin sheath requires high levels of fatty acid and lipid synthesis, together with uptake of extracellular fatty acids. Recent studies have further advanced our understanding of the metabolism and functions of myelin fatty acids and lipids. In this review, we present an overview of the basic biology of myelin lipids and recent insights on the regulation of fatty acid metabolism and functions in myelinating cells. In addition, this review may serve to provide a foundation for future research characterizing the role of fatty acids and lipids in myelin biology and metabolic disorders affecting the central and peripheral nervous system. View Full-Text
Keywords: Schwann cell; oligodendrocyte; myelin; lipid; fatty acid Schwann cell; oligodendrocyte; myelin; lipid; fatty acid
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MDPI and ACS Style

Poitelon, Y.; Kopec, A.M.; Belin, S. Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism. Cells 2020, 9, 812. https://doi.org/10.3390/cells9040812

AMA Style

Poitelon Y, Kopec AM, Belin S. Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism. Cells. 2020; 9(4):812. https://doi.org/10.3390/cells9040812

Chicago/Turabian Style

Poitelon, Yannick, Ashley M. Kopec, and Sophie Belin. 2020. "Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism" Cells 9, no. 4: 812. https://doi.org/10.3390/cells9040812

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