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Cells 2018, 7(9), 128; https://doi.org/10.3390/cells7090128

Evaluation of Unconventional Protein Secretion by Saccharomyces cerevisiae and other Fungi

1
Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599-8531, Japan
2
Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
*
Author to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 27 August 2018 / Accepted: 27 August 2018 / Published: 31 August 2018
(This article belongs to the Special Issue Unconventional Protein Secretion in Development and Disease)
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Abstract

Development of proteome analysis of extracellular proteins has revealed that a wide variety of proteins, including fungal allergens are present outside the cell. These secreted allergens often do not contain known secretion signal sequences. Recent research progress shows that some fungal allergens are secreted by unconventional secretion pathways, including autophagy- and extracellular-vesicle-dependent pathways. However, secretion pathways remain unknown for the majority of extracellular proteins. This review summarizes recent data on unconventional protein secretion in Saccharomyces cerevisiae and other fungi. Particularly, methods for evaluating unconventional protein secretion are proposed for fungal species, including S. cerevisiae, a popular model organism for investigating protein secretion pathways. View Full-Text
Keywords: protein secretion; Saccharomyces cerevisiae; unconventional secretion pathway; fungal allergens protein secretion; Saccharomyces cerevisiae; unconventional secretion pathway; fungal allergens
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Miura, N.; Ueda, M. Evaluation of Unconventional Protein Secretion by Saccharomyces cerevisiae and other Fungi. Cells 2018, 7, 128.

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