Table of Contents
Cells, Volume 7, Issue 8 (August 2018)
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Cover Story (view full-size image) While cancer immune therapy has revolutionized the treatment of metastatic cancer, a major limiting [...] Read more. While cancer immune therapy has revolutionized the treatment of metastatic cancer, a major limiting factor remains the inadequate homing of anti-tumor immune cells to the tumor site. Current strategies are addressing the issue of homing by genetically engineering T cells with chemokine receptors, fixing T cells with GPS coordinates to the tumor. We hypothesize a role for exercise conditioning to normalize poor tumor vascularization and the lack of appropriate adhesion/extravasation molecules, creating highways to the tumor. View this paper.