You are currently viewing a new version of our website. To view the old version click .

Cells, Volume 13, Issue 21

November-1 2024 - 75 articles

Cover Story: Besides being part of the chromosomal passenger complex (CPC), recent findings suggest additional roles for Survivin in the DNA damage response, further contributing to therapy resistance. Ionizing radiation leads to increased expression of Survivin and its accumulation in heterochromatic nuclear foci. Survivin depletion not only results in impaired repair capacity and unphysiological genome replication via mitotic DNA synthesis, but also reduces replication fork speed in the S phase. Here, the CPC member INCENP mediates the interaction with the processivity factor PCNA, and Aurora B kinase liberates Pol η by phosphorylating its interaction partner POLDIP2 to resume the replication of damaged sites by translesion synthesis. Thus, we assigned a direct function to the CPC in the transition from stalled replication forks to translesion synthesis. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (75)

  • Review
  • Open Access
9 Citations
4,826 Views
25 Pages

Mitochondrial Dysfunction and Metabolic Disturbances Induced by Viral Infections

  • Sandra E. Pérez,
  • Monika Gooz and
  • Eduardo N. Maldonado

29 October 2024

Viruses are intracellular parasites that utilize organelles, signaling pathways, and the bioenergetics machinery of the cell to replicate the genome and synthesize proteins to build up new viral particles. Mitochondria are key to supporting the virus...

  • Review
  • Open Access
72 Citations
19,646 Views
22 Pages

Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence

  • Faiza Mahmud,
  • Drishty B. Sarker,
  • Jonathan A. Jocelyn and
  • Qing-Xiang Amy Sang

29 October 2024

Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, and increasing industrial production have led to questions about their long-term impact on human and animal health. This narrative review...

  • Article
  • Open Access
1 Citations
1,929 Views
17 Pages

Adipose Tissue Macrophages of the Human Fetus

  • Ádám Radványi,
  • Katalin Gyurina,
  • Emese Rácz,
  • Ilona Kovács,
  • Gábor Méhes and
  • Tamás Röszer

28 October 2024

Prenatal adipose tissue development affects body composition and growth trajectory in early infancy, therefore it is a key determinant of adiposity in childhood. Childhood overweight and obesity increase the probability of being obese as an adult. Af...

  • Article
  • Open Access
2 Citations
2,088 Views
14 Pages

Eosinophil–Basophil/Lymphocyte (EB/LR) and Eosinophil–Basophil–Platelet/Lymphocyte (EBP/LR) Ratios Could Serve as Useful Additional Markers for Assessing the Severity of Wasp Allergic Reactions

  • Weronika Urbańska,
  • Łukasz Szymański,
  • Aneta Lewicka,
  • Martyna Ciepielak,
  • Karolina Kostrzeńska-Sęk,
  • Andrzej Chciałowski and
  • Sławomir Lewicki

28 October 2024

Wasp venom allergy can trigger severe allergic reactions, and predicting these acute responses remains challenging. This study evaluates the utility of immune system indexes, particularly the eosinophil–basophil/lymphocyte (EB/LR) and eosinophi...

  • Review
  • Open Access
4 Citations
2,820 Views
25 Pages

Prognostic Indicators for Precision Treatment of Non-Small Cell Lung Carcinoma

  • Damayanti Das Ghosh,
  • Hannah McDonald,
  • Rajeswari Dutta,
  • Keerthana Krishnan,
  • Jaya Thilakan,
  • Manash K. Paul,
  • Neha Arya,
  • Mahadev Rao and
  • Vivek M. Rangnekar

28 October 2024

Non-small cell lung cancer (NSCLC) has established predictive biomarkers that enable decisions on treatment regimens for many patients. However, resistance to therapy is widespread. It is therefore essential to have a panel of molecular biomarkers th...

  • Article
  • Open Access
2 Citations
2,777 Views
13 Pages

28 October 2024

The intestines are in a constant state of motion and self-renewal. The mechanical breakdown of food facilitates intestinal movement and aids digestion. It is believed that mechanical stimulation, triggered by changes in osmotic pressure within the in...

  • Review
  • Open Access
9 Citations
7,409 Views
19 Pages

Islet Transplantation: Current Limitations and Challenges for Successful Outcomes

  • Allan Langlois,
  • Michel Pinget,
  • Laurence Kessler and
  • Karim Bouzakri

28 October 2024

Islet transplantation is a promising approach for treating patients with unstable T1DM. However, it is confronted with numerous obstacles throughout the various stages of the transplantation procedure. Significant progress has been made over the last...

  • Article
  • Open Access
5 Citations
3,391 Views
16 Pages

Improving the Genome Editing Efficiency of CRISPR/Cas9 in Melon and Watermelon

  • Zhuanrong Wang,
  • Lili Wan,
  • Jian Ren,
  • Na Zhang,
  • Hongxia Zeng,
  • Jiaqi Wei and
  • Mi Tang

28 October 2024

CRISPR/Cas9 is a powerful genome editing tool for trait improvement in various crops; however, enhancing mutation efficiency using CRISPR/Cas9 in watermelon and melon remains challenging. We designed four CRISPR systems with different sgRNA expressio...

  • Article
  • Open Access
2,287 Views
14 Pages

28 October 2024

Osteoporosis is a common skeletal disease, primarily associated with aging, that results from decreased bone density and bone volume. This reduction significantly increases the risk of fractures in osteoporosis patients compared to individuals with n...

of 8

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Cells - ISSN 2073-4409