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Open AccessReview

Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms

1
INSERM UMR_S 999, Hypertension Pulmonaire: Physiopathologie et Innovation Thérapeutique, Hôpital Marie Lannelongue, F-92350 Le Plessis-Robinson, France
2
Faculté de Médecine, Université Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France
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Cardiovascular R&D Center, Faculty of Medicine of the University of Porto, 4200-450 Porto, Portugal
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Paris-Porto Pulmonary Hypertension Collaborative Laboratory (3PH), UMR_S 999, INSERM, Université Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France
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Institute of Experimental and Clinical Research (IREC), Pneumology, ENT and Dermatology, Université catholique de Louvain (UCL), 1060 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Stephen Y. Chan
Cells 2021, 10(2), 477; https://doi.org/10.3390/cells10020477 (registering DOI)
Received: 13 January 2021 / Revised: 13 February 2021 / Accepted: 18 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue Cellular Pathogenesis of Pulmonary Arterial Hypertension)
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss the potential implications of iron deficiency on the development and management of PAH. View Full-Text
Keywords: pulmonary arterial hypertension; iron deficiency; cardiovascular disease; iron homeostasis pulmonary arterial hypertension; iron deficiency; cardiovascular disease; iron homeostasis
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MDPI and ACS Style

Quatredeniers, M.; Mendes-Ferreira, P.; Santos-Ribeiro, D.; Nakhleh, M.K.; Ghigna, M.-R.; Cohen-Kaminsky, S.; Perros, F. Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms. Cells 2021, 10, 477. https://doi.org/10.3390/cells10020477

AMA Style

Quatredeniers M, Mendes-Ferreira P, Santos-Ribeiro D, Nakhleh MK, Ghigna M-R, Cohen-Kaminsky S, Perros F. Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms. Cells. 2021; 10(2):477. https://doi.org/10.3390/cells10020477

Chicago/Turabian Style

Quatredeniers, Marceau; Mendes-Ferreira, Pedro; Santos-Ribeiro, Diana; Nakhleh, Morad K.; Ghigna, Maria-Rosa; Cohen-Kaminsky, Sylvia; Perros, Frédéric. 2021. "Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms" Cells 10, no. 2: 477. https://doi.org/10.3390/cells10020477

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