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The Role of Gonadotropin-Releasing Hormone (GnRH) in Endometrial Cancer
Review

Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer

Department of Gynecology and Obstetrics, University Medicine Göttingen, 37075 Göttingen, Germany
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Author to whom correspondence should be addressed.
Academic Editors: Marcello Maggiolini and Pritinder Kaur
Cells 2021, 10(2), 437; https://doi.org/10.3390/cells10020437
Received: 22 December 2020 / Revised: 28 January 2021 / Accepted: 17 February 2021 / Published: 18 February 2021
The hypothalamus–pituitary–gonadal (HPG) axis is the endocrine regulation system that controls the woman’s cycle. The gonadotropin-releasing hormone (GnRH) plays the central role. In addition to the gonadotrophic cells of the pituitary, GnRH receptors are expressed in other reproductive organs, such as the ovary and in tumors originating from the ovary. In ovarian cancer, GnRH is involved in the regulation of proliferation and metastasis. The effects on ovarian tumors can be indirect or direct. GnRH acts indirectly via the HPG axis and directly via GnRH receptors on the surface of ovarian cancer cells. In this systematic review, we will give an overview of the role of GnRH in ovarian cancer development, progression and therapy. View Full-Text
Keywords: ovarian cancer; gonadotropin-releasing hormone; GnRH; LHRH ovarian cancer; gonadotropin-releasing hormone; GnRH; LHRH
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MDPI and ACS Style

Gründker, C.; Emons, G. Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer. Cells 2021, 10, 437. https://doi.org/10.3390/cells10020437

AMA Style

Gründker C, Emons G. Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer. Cells. 2021; 10(2):437. https://doi.org/10.3390/cells10020437

Chicago/Turabian Style

Gründker, Carsten, and Günter Emons. 2021. "Role of Gonadotropin-Releasing Hormone (GnRH) in Ovarian Cancer" Cells 10, no. 2: 437. https://doi.org/10.3390/cells10020437

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