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Article

Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells

1
Institute for Advanced Biosciences, UMR CNRS 5309/INSERM U1209, Université Grenoble-Alpes, 38400 Grenoble, France
2
Centre de Recherche en Cancérologie de Lyon, UMR CNRS 5286/INSERM U1052, Université de Lyon, 69008 Lyon, France
*
Author to whom correspondence should be addressed.
A.K.D. and A.G. equally contributed.
Cells 2021, 10(1), 96; https://doi.org/10.3390/cells10010096
Received: 30 November 2020 / Revised: 18 December 2020 / Accepted: 4 January 2021 / Published: 7 January 2021
(This article belongs to the Special Issue Nanotechnology in Health and Diseases: A Double-Edge Sword)
Gold nanoparticles (AuNPs) have demonstrated outstanding performance in many biomedical applications. Their safety is recognised; however, their effects on the immune system remain ill defined. Antigen-presenting cells (APCs) are immune cells specialised in sensing external stimulus and in capturing exogenous materials then delivering signals for the immune responses. We used primary macrophages (Ms) and dendritic cells (DCs) of mice as an APC model. Whereas AuNPs did not alter significantly Ms and DCs functions, the exposure to AuNPs affected differently Ms and DCs in their responses to subsequent stimulations. The secretion of inflammatory molecules like cytokines (IL-6, TNF-α), chemokine (MCP-1), and reactive oxygen species (ROS) were altered differently in Ms and DCs. Furthermore, the metabolic activity of Ms was affected with the increase of mitochondrial respiration and glycolysis, while only a minor effect was seen on DCs. Antigen presentation to T cells increased when DCs were exposed to AuNPs leading to stronger Th1, Th2, and Th17 responses. In conclusion, our data provide new insights into the complexity of the effects of AuNPs on the immune system. Although AuNPs may be considered as devoid of significant effect, they may induce discrete modifications on some functions that can differ among the immune cells. View Full-Text
Keywords: antigen presenting cells; phagocytic cells; immunotoxicity; inflammation; immuno-metabolism antigen presenting cells; phagocytic cells; immunotoxicity; inflammation; immuno-metabolism
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MDPI and ACS Style

Dey, A.K.; Gonon, A.; Pécheur, E.-I.; Pezet, M.; Villiers, C.; Marche, P.N. Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells. Cells 2021, 10, 96. https://doi.org/10.3390/cells10010096

AMA Style

Dey AK, Gonon A, Pécheur E-I, Pezet M, Villiers C, Marche PN. Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells. Cells. 2021; 10(1):96. https://doi.org/10.3390/cells10010096

Chicago/Turabian Style

Dey, Arindam K., Alexis Gonon, Eve-Isabelle Pécheur, Mylène Pezet, Christian Villiers, and Patrice N. Marche. 2021. "Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells" Cells 10, no. 1: 96. https://doi.org/10.3390/cells10010096

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