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Polymers
Volume 13
Issue 16
10.3390/polym13162583
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Article

Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery

by
Nina Hartini
1,
Thangavel Ponrasu
1,
Jia-Jiuan Wu
2,
Malinee Sriariyanun
3 and
Yu-Shen Cheng
1,*
1
Department Chemical and Materials Engineering, National Yunlin University of Science and Technology, 123 University Road, Section 3, Douliu, Yunlin 64002, Taiwan
2
Department of Nutrition, China Medical University, 91 Hsueh-Shih Rd., Taichung 40402, Taiwan
3
The Sirindhorn International Thai-German Graduate School of Engineering, King Mongkut’s University of Technology North Bangkok, Bangsue, Bangkok 10800, Thailand
*
Author to whom correspondence should be addressed.
Polymers 2021, 13(16), 2583; https://doi.org/10.3390/polym13162583
Submission received: 30 June 2021 / Revised: 25 July 2021 / Accepted: 26 July 2021 / Published: 4 August 2021
(This article belongs to the Special Issue Advances in Functional Polymeric Materials)
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Abstract

Microencapsulation of curcumin in jelly fig pectin was performed by the vacuum spray drying (VSD) technique. The VSD was advanced with a low inlet temperature of 80–90 °C and low pressure of 0.01 mPa. By the in situ cross-linking with multivalent calcium ions, jelly fig pectin produced stable curcumin encapsulated microparticles. The physiochemical characteristics of microparticles were thoroughly investigated. The results revealed that 0.75 w/w% of jelly fig pectin and inlet temperature of 90 °C could be feasible for obtaining curcumin microparticles. The VSD technique showed the best encapsulation efficiency and yield and loading efficiency was up to 91.56 ± 0.80%, 70.02 ± 1.96%, and 5.45 ± 0.14%, respectively. The curcumin was readily released into simulated gastrointestinal fluid with 95.34 ± 0.78% cumulative release in 24 h. The antioxidant activity was stable after being stored for six months and stored as a solution for seven days at room temperature before analysis. Hence, the VSD technique could be applicable for the microencapsulation of bioactive compounds such as curcumin to protect and use in the food/pharmaceutical industry.
Keywords: microencapsulation; curcumin; jelly fig pectin; vacuum spray drying; drug delivery microencapsulation; curcumin; jelly fig pectin; vacuum spray drying; drug delivery
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MDPI and ACS Style

Hartini, N.; Ponrasu, T.; Wu, J.-J.; Sriariyanun, M.; Cheng, Y.-S. Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery. Polymers 2021, 13, 2583. https://doi.org/10.3390/polym13162583

AMA Style

Hartini N, Ponrasu T, Wu J-J, Sriariyanun M, Cheng Y-S. Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery. Polymers. 2021; 13(16):2583. https://doi.org/10.3390/polym13162583

Chicago/Turabian Style

Hartini, Nina, Thangavel Ponrasu, Jia-Jiuan Wu, Malinee Sriariyanun, and Yu-Shen Cheng. 2021. "Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery" Polymers 13, no. 16: 2583. https://doi.org/10.3390/polym13162583

APA Style

Hartini, N., Ponrasu, T., Wu, J.-J., Sriariyanun, M., & Cheng, Y.-S. (2021). Microencapsulation of Curcumin in Crosslinked Jelly Fig Pectin Using Vacuum Spray Drying Technique for Effective Drug Delivery. Polymers, 13(16), 2583. https://doi.org/10.3390/polym13162583

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