Next Article in Journal
Synthesis and Characterization of Te Nanotubes Decorated with Pt Nanoparticles for a Fuel Cell Anode/Cathode Working at a Neutral pH
Next Article in Special Issue
Hydrosoluble Complexes Bearing Tris(pyrazolyl)methane Sulfonate Ligand: Synthesis, Characterization and Catalytic Activity for Henry Reaction
Previous Article in Journal
Long-Term Storage and Use of Artificially Immobilized Anaerobic Sludge as a Powerful Biocatalyst for Conversion of Various Wastes Including Those Containing Xenobiotics to Biogas
Open AccessCommunication

Synthesis and Organocatalytic Asymmetric Nitro-aldol Initiated Cascade Reactions of 2-Acylbenzonitriles Leading to 3,3-Disubstituted Isoindolinones

1
Dipartimento di Chimica e Biologia, Università di Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy
2
Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz, Austria
*
Authors to whom correspondence should be addressed.
Catalysts 2019, 9(4), 327; https://doi.org/10.3390/catal9040327
Received: 7 March 2019 / Revised: 27 March 2019 / Accepted: 28 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue Catalysts for Henry Reaction)
In this work, we investigated two strategies for the synthesis of the challenging ketones 2-acylbenzonitriles and we report their use as electrophiles in asymmetric organocatalytic cascade reactions with nitromethane. Promising results were obtained in the presence of chiral bifunctional ammonium salts under phase transfer conditions, which led to novel 3,3-disubstituted isoindolinones in quantitative yields and moderate enantioselectivity. View Full-Text
Keywords: cascade reactions; Henry-reactions; asymmetric organocatalysis; isoindolinone; heterocycles; ketones as electrophiles cascade reactions; Henry-reactions; asymmetric organocatalysis; isoindolinone; heterocycles; ketones as electrophiles
Show Figures

Graphical abstract

MDPI and ACS Style

Romano, F.; Di Mola, A.; Palombi, L.; Tiffner, M.; Waser, M.; Massa, A. Synthesis and Organocatalytic Asymmetric Nitro-aldol Initiated Cascade Reactions of 2-Acylbenzonitriles Leading to 3,3-Disubstituted Isoindolinones. Catalysts 2019, 9, 327.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop