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Cancers, Volume 9, Issue 8

August 2017 - 15 articles

Cover Story: Metastasis of epithelial ovarian cancer (EOC) occurs primarily via transcoelomic dissemination of shed tumor cells and multicellular aggregates that avoid anoikis and ultimately adhere to and anchor within the submesothelial lining of the peritoneal cavity to generate widely disseminated metastases. This unique microenvironment is highly permissive for phenotypic plasticity. In this review, we summarize current knowledge of EOC heterogeneity in the context of epithelial:mesenchymal and mesenchymal:epithelial transition (EMT, MET), outline regulators of this process, address controversies in EMT and chemoresistance, and highlight computational modeling approaches toward a better understanding EMT/MET in EOC. View this paper

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Articles (15)

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Article

29 Citations

8,273 Views

14 Pages

Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer

David R. Hout,
Brock L. Schweitzer,
Kasey Lawrence,
Stephan W. Morris,
Tracy Tucker,
Rosetta Mazzola,
Rachel Skelton,
Frank McMahon,
John Handshoe and
Mary Lesperance
+ 2 authors

Cancers2017, 9(8), 99;https://doi.org/10.3390/cancers9080099

1 August 2017

Patients with lung cancers harboring an activating anaplastic lymphoma kinase (ALK) rearrangement respond favorably to ALK inhibitor therapy. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are validated and widely used scree...

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Review

74 Citations

13,266 Views

15 Pages

EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids

Elvira Forte,
Isotta Chimenti,
Paolo Rosa,
Francesco Angelini,
Francesca Pagano,
Antonella Calogero,
Alessandro Giacomello and
Elisa Messina

Cancers2017, 9(8), 98;https://doi.org/10.3390/cancers9080098

29 July 2017

The epithelial-to-mesenchymal transition (EMT) is an essential trans-differentiation process, which plays a critical role in embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. It is the fundamental mech...

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Commentary

9 Citations

7,209 Views

14 Pages

Localization of VEGF to Vascular ECM Is an Important Aspect of Tumor Angiogenesis

Weon-Kyoo You and
William B. Stallcup

Cancers2017, 9(8), 97;https://doi.org/10.3390/cancers9080097

28 July 2017

Our research has identified several examples in which reduced VEGF-A binding to deficient vascular extracellular matrix leads to deficits in tumor vascularization and tumor growth: (1) germline ablation of collagen VI in the stroma of intracranial B1...

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Review

111 Citations

8,799 Views

8 Pages

Integrins and Exosomes, a Dangerous Liaison in Cancer Progression

Mayra Paolillo and
Sergio Schinelli

Cancers2017, 9(8), 95;https://doi.org/10.3390/cancers9080095

26 July 2017

Integrin activity and function is classically related to the bi-directional regulation of cell-extracellular matrix (ECM) contacts that regulate a number of cell pathways linked to cell adhesion, cell detachment from ECM, cell migration, and anoikis....

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Article

36 Citations

7,155 Views

15 Pages

Involvement of the Integrin α1β1 in the Progression of Colorectal Cancer

Salah Boudjadi,
Gérald Bernatchez,
Blanche Sénicourt,
Marco Beauséjour,
Pierre H. Vachon,
Julie C. Carrier and
Jean-François Beaulieu

Cancers2017, 9(8), 96;https://doi.org/10.3390/cancers9080096

26 July 2017

Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling that participate in the regulation of cell shape, adhesion, migration, survival and proliferation. The integrin α1β1 is known to be involved in RAS/ERK pro...

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