Next Article in Journal
Localization of VEGF to Vascular ECM Is an Important Aspect of Tumor Angiogenesis
Next Article in Special Issue
Integrins as Therapeutic Targets: Successes and Cancers
Previous Article in Journal / Special Issue
Integrins and Exosomes, a Dangerous Liaison in Cancer Progression
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Cancers 2017, 9(8), 96; https://doi.org/10.3390/cancers9080096

Involvement of the Integrin α1β1 in the Progression of Colorectal Cancer

1
Laboratory of Intestinal Physiopathology, Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
2
Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Helen M. Sheldrake
Received: 28 June 2017 / Revised: 18 July 2017 / Accepted: 21 July 2017 / Published: 26 July 2017
(This article belongs to the Special Issue Integrins in Cancer)
Full-Text   |   PDF [4970 KB, uploaded 3 August 2017]   |  

Abstract

Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling that participate in the regulation of cell shape, adhesion, migration, survival and proliferation. The integrin α1β1 is known to be involved in RAS/ERK proliferative pathway activation and plays an important role in fibroblast proliferation. In the small intestine, the integrin α1 subunit is present in the crypt proliferative compartment and absent in the villus. We have recently shown that the integrin α1 protein and transcript (ITGA1) are present in a large proportion of colorectal cancers (CRC) and that their expression is controlled by the MYC oncogenic factor. Considering that α1 subunit/ITGA1 expression is correlated with MYC in more than 70% of colon adenocarcinomas, we postulated that the integrin α1β1 has a pro-tumoral contribution to CRC. In HT29, T84 and SW480 CRC cells, α1 subunit/ITGA1 knockdown resulted in a reduction of cell proliferation associated with an impaired resistance to anoikis and an altered cell migration in HT29 and T84 cells. Moreover, tumor development in xenografts was reduced in HT29 and T84 sh-ITGA1 cells, associated with extensive necrosis, a low mitotic index and a reduced number of blood vessels. Our results show that α1β1 is involved in tumor cell proliferation, survival and migration. This finding suggests that α1β1 contributes to CRC progression. View Full-Text
Keywords: ITGA1; integrin α1; proliferation; survival; colorectal cancer; cell migration ITGA1; integrin α1; proliferation; survival; colorectal cancer; cell migration
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Boudjadi, S.; Bernatchez, G.; Sénicourt, B.; Beauséjour, M.; Vachon, P.H.; Carrier, J.C.; Beaulieu, J.-F. Involvement of the Integrin α1β1 in the Progression of Colorectal Cancer. Cancers 2017, 9, 96.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top