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Cancers, Volume 14, Issue 4

February-2 2022 - 245 articles

Cover Story: Cancer is a disease with one of the highest mortality rates worldwide. Of the current strategies to study new diagnostic and treating tools, organs-on-a-chip are quite promising regarding the achievement of more personalized medicine. In this review, 75 out of 820 of the most recent published scientific articles were selected and analyzed through a systematic process, following the research guidelines for systematic reviews proposed by PRISMA. The selected articles present different advanced microfluidic platforms where cell culture models were used for the evaluation of cancer treatments’ efficacy and/or toxicity. Overall, the use of organs-on-a-chip presents several advantages when compared to 2D cultures. The combination of different organ models on a chip also contributes to a more accurate evaluation of drug effects. View this paper
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Articles (245)

  • Article
  • Open Access
22 Citations
3,644 Views
11 Pages

External Validation of a Radiomics Model for the Prediction of Complete Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer

  • Anaïs Bordron,
  • Emmanuel Rio,
  • Bogdan Badic,
  • Omar Miranda,
  • Olivier Pradier,
  • Mathieu Hatt,
  • Dimitris Visvikis,
  • François Lucia,
  • Ulrike Schick and
  • Vincent Bourbonne

21 February 2022

Objective: Our objective was to develop a radiomics model based on magnetic resonance imaging (MRI) and contrast-enhanced computed tomography (CE-CT) to predict pathological complete response (pCR) to neoadjuvant treatment in locally advanced rectal...

  • Article
  • Open Access
3 Citations
3,007 Views
14 Pages

Alpha-Emitter Radiopharmaceuticals and External Beam Radiotherapy: A Radiobiological Model for the Combined Treatment

  • Anna Sarnelli,
  • Maria Luisa Belli,
  • Irene Azzali,
  • Emiliano Loi,
  • Stefano Severi and
  • Lidia Strigari

21 February 2022

Previously published studies combined external beam radiotherapy (EBRT) treatments with different activities of 223Ra. The data of two-year overall survival (2y-OS) and neutropenia (TOX) incidence when combining EBRT and 223Ra are not homogeneous in...

  • Article
  • Open Access
14 Citations
27,107 Views
12 Pages

Lymphatic Function of the Lower Limb after Groin Dissection for Vulvar Cancer and Reconstruction with Lymphatic SCIP Flap

  • Anna Amelia Caretto,
  • Gianluigi Stefanizzi,
  • Simona Maria Fragomeni,
  • Alex Federico,
  • Luca Tagliaferri,
  • Valentina Lancellotta,
  • Giovanni Scambia and
  • Stefano Gentileschi

21 February 2022

Inguinofemoral lymphadenectomy, frequently performed for vulvar cancer, is burdened with substantial immediate and long-term morbidity. One of the most disabling treatment-related sequelae is lower limb lymphedema (LLL). The present study aims to des...

  • Article
  • Open Access
32 Citations
4,595 Views
15 Pages

Test/Retest Reliability and Validity of Remote vs. In-Person Anthropometric and Physical Performance Assessments in Cancer Survivors and Supportive Partners

  • Teri W. Hoenemeyer,
  • William W. Cole,
  • Robert A. Oster,
  • Dorothy W. Pekmezi,
  • Andrea Pye and
  • Wendy Demark-Wahnefried

21 February 2022

(1) Background: Anthropometric and physical performance testing is commonly done in lifestyle research and is traditionally performed in-person. To expand the scalability of lifestyle interventions among cancer survivors, in-person assessments were a...

  • Article
  • Open Access
4 Citations
3,214 Views
32 Pages

Comparative Panel Sequencing of DNA Variants in cf-, ev- and tumorDNA for Pancreatic Ductal Adenocarcinoma Patients

  • Mareike Waldenmaier,
  • Lucas Schulte,
  • Jonathan Schönfelder,
  • Axel Fürstberger,
  • Johann M. Kraus,
  • Nora Daiss,
  • Tanja Seibold,
  • Mareen Morawe,
  • Thomas J. Ettrich and
  • Hans A. Kestler
  • + 3 authors

21 February 2022

Pancreatic ductal adenocarcinomas (PDACs) are tumors with poor prognosis and limited treatment options. Personalized medicine aims at characterizing actionable DNA variants by next-generation sequencing, thereby improving treatment strategies and out...

  • Systematic Review
  • Open Access
27 Citations
5,323 Views
12 Pages

A Global Evaluation of the Performance Indicators of Colorectal Cancer Screening with Fecal Immunochemical Tests and Colonoscopy: A Systematic Review and Meta-Analysis

  • Hanyue Ding,
  • Jiaye Lin,
  • Zijun Xu,
  • Xiao Chen,
  • Harry H. X. Wang,
  • Liwen Huang,
  • Junjie Huang,
  • Zhijie Zheng and
  • Martin C. S. Wong

21 February 2022

(1) Background: To summarize the achievements of the performance indicators of colorectal cancer (CRC) screening programs that used the fecal immunochemical test (FIT) as a primary screening modality and colonoscopy as a subsequent confirmatory test....

  • Article
  • Open Access
5 Citations
2,866 Views
9 Pages

The Impact of Frailty Screening on Radiation Treatment Modification

  • Encarnación Fernández-Camacho,
  • Carlos Ferrer-Ramos,
  • Virginia Morilllo-Macías,
  • Marta Rodríguez-Cordón,
  • Ángel Sánchez-Iglesias,
  • Inmaculada Beato-Tortajada,
  • Alicia Francés-Muñoz,
  • Rodrigo Muelas-Soria,
  • Teresa Piquer-Camañes and
  • Ana Isabel Santafé-Jiménez
  • + 2 authors

21 February 2022

Background: Care overburden makes it difficult to perform comprehensive geriatric assessments (CGAs) in oncology settings. We analyzed if screening tools modified radiotherapy in oncogeriatric patients. Methods: Patients ≥ 65 years, irradiated bet...

  • Article
  • Open Access
17 Citations
3,643 Views
18 Pages

ADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6

  • Marlene Vierthaler,
  • Qian Sun,
  • Yiman Wang,
  • Tamara Steinfass,
  • Juliane Poelchen,
  • Thomas Hielscher,
  • Daniel Novak,
  • Viktor Umansky and
  • Jochen Utikal

20 February 2022

Background: ADCK2 is a member of the AarF domain-containing kinase family, which consists of five members, and has been shown to play a role in CoQ metabolism. However, ADCKs have also been connected to cancer cell survival, proliferation and motilit...

  • Article
  • Open Access
16 Citations
3,973 Views
21 Pages

Combination of Resminostat with Ruxolitinib Exerts Antitumor Effects in the Chick Embryo Chorioallantoic Membrane Model for Cutaneous T Cell Lymphoma

  • Fani Karagianni,
  • Christina Piperi,
  • Berta Casar,
  • Dalia de la Fuente-Vivas,
  • Rocío García-Gómez,
  • Kyriaki Lampadaki,
  • Vasiliki Pappa and
  • Evangelia Papadavid

20 February 2022

The combination of Resminostat (HDACi) and Ruxolitinib (JAKi) exerted cytotoxic effects and inhibited proliferation of CTCL cell lines (MyLa, SeAx) in previously published work. A xenograft tumor formation was produced by implanting the MyLa or SeAx...

  • Review
  • Open Access
8 Citations
5,050 Views
15 Pages

Use of Patient-Derived Organoids as a Treatment Selection Model for Colorectal Cancer: A Narrative Review

  • Sara Furbo,
  • Paulo César Martins Urbano,
  • Hans Henrik Raskov,
  • Jesper Thorvald Troelsen,
  • Anne-Marie Kanstrup Fiehn and
  • Ismail Gögenur

20 February 2022

Surgical resection is the mainstay in intended curative treatment of colorectal cancer (CRC) and may be accompanied by adjuvant chemotherapy. However, 40% of the patients experience recurrence within five years of treatment, highlighting the importan...

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Cancers - ISSN 2072-6694